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Abstract
A rat fed an excess of tyrosine develops a reproducible, reversible keratopathy. Topical, intramuscular, or oral administration of various glucocorticoids and intramuscular phenobarbital prevent the development of tyrosine-induced corneal opacity, edema, and vascularization in a graduated fashion. Steroid drops placed in the right eye only inhibit development of keratopathy in both eyes. It is suggested that this delaying of keratopathy is due to stimulation of hepatic production of tyrosine aminotransferase.