January 1974
Volume 13, Issue 1
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Articles  |   January 1974
Modification of 1-Tyrosine-Induced Keratopathy by Adrenal Corticosteroids
Author Affiliations
  • ROBERT P. BURNS
    John E. Weeks Institute for the Advancement of Ophthalmology, University of Oregon Medical School, Portland, Ore
  • MARGARET E. BEARD
    John E. Weeks Institute for the Advancement of Ophthalmology, University of Oregon Medical School, Portland, Ore
  • VIRGINIA L. WEIMAR
    John E. Weeks Institute for the Advancement of Ophthalmology, University of Oregon Medical School, Portland, Ore
  • EDWIN L. SQUIRES
    John E. Weeks Institute for the Advancement of Ophthalmology, University of Oregon Medical School, Portland, Ore
Investigative Ophthalmology & Visual Science January 1974, Vol.13, 39-45. doi:
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      ROBERT P. BURNS, MARGARET E. BEARD, VIRGINIA L. WEIMAR, EDWIN L. SQUIRES; Modification of 1-Tyrosine-Induced Keratopathy by Adrenal Corticosteroids. Invest. Ophthalmol. Vis. Sci. 1974;13(1):39-45.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A rat fed an excess of tyrosine develops a reproducible, reversible keratopathy. Topical, intramuscular, or oral administration of various glucocorticoids and intramuscular phenobarbital prevent the development of tyrosine-induced corneal opacity, edema, and vascularization in a graduated fashion. Steroid drops placed in the right eye only inhibit development of keratopathy in both eyes. It is suggested that this delaying of keratopathy is due to stimulation of hepatic production of tyrosine aminotransferase.

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