October 1974
Volume 13, Issue 10
Articles  |   October 1974
Mechanisms Initiating Cataract Formation Proctor Lecture
Author Affiliations
    Laboratory of Vision Research, National Eye Institute, National Institutes of Health, United States Department of Health, Education, and Welfare Bethesda, Md. 20014
Investigative Ophthalmology & Visual Science October 1974, Vol.13, 713-724. doi:
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      JIN H. KINOSHITA; Mechanisms Initiating Cataract Formation Proctor Lecture. Invest. Ophthalmol. Vis. Sci. 1974;13(10):713-724.

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      © ARVO (1962-2015); The Authors (2016-present)

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Osmotic swelling is a common feature of many cataracts. Sugar cataracts and hereditary mouse cataracts are two types in which osmotic changes play a prominent role. In sugar cataracts, the initial swelling brought about by polyol accumuation leads to an imbalance in the pump-leak equilibrium. The pump mechanism becomes unable to keep pace with the leaky membranes. The marked increases in Na and Cl eventually results in Donnan swelling. In the hereditary mouse cataract, the imbalance of the pump-leak system appears to be initiated by a deficiency of Na-K ATPase, a component of the cation pump mechanism. The inefficiency in the pump mechanism results in Na retention and osmotic swelling.


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