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RICHARD M. ROBB; Histochemical Evidence of Cyclic Nucleotide Phosphodiesterase in Photoreceptor Outer Segments. Invest. Ophthalmol. Vis. Sci. 1974;13(10):740-747.
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A histochemical demonstration of cyclic 3',5'-nucleotide phosphodiesterase in retinal photoreceptor outer segments is reported for the first time. The enzyme appears to be located on outer segment lamellae. It is not found in adjacent inner segment or nuclear regions. This histochemical localization is consistent with previously reported biochemical studies showing high phosphodiesterase activity in preparations of isolated rod outer segments.
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