October 1974
Volume 13, Issue 10
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Articles  |   October 1974
Histochemical Evidence of Cyclic Nucleotide Phosphodiesterase in Photoreceptor Outer Segments
Author Affiliations
  • RICHARD M. ROBB
    Department of Ophthalmology, Children's Hospital Medical Center and Harvard Medical School, Boston, Mass.
Investigative Ophthalmology & Visual Science October 1974, Vol.13, 740-747. doi:
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      RICHARD M. ROBB; Histochemical Evidence of Cyclic Nucleotide Phosphodiesterase in Photoreceptor Outer Segments. Invest. Ophthalmol. Vis. Sci. 1974;13(10):740-747.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A histochemical demonstration of cyclic 3',5'-nucleotide phosphodiesterase in retinal photoreceptor outer segments is reported for the first time. The enzyme appears to be located on outer segment lamellae. It is not found in adjacent inner segment or nuclear regions. This histochemical localization is consistent with previously reported biochemical studies showing high phosphodiesterase activity in preparations of isolated rod outer segments.

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