June 1974
Volume 13, Issue 6
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Articles  |   June 1974
Permeability of the Isolated Rabbit Cornea to Corticosteroids
Author Affiliations
  • DAVID S. HULL
    Departments of Physiology and Ophthalmology, The Medical College of Wisconsin (formerly, Marquette University School of Medicine), Milwaukee, Wis.
  • JAMES E. HINE
    Departments of Physiology and Ophthalmology, The Medical College of Wisconsin (formerly, Marquette University School of Medicine), Milwaukee, Wis.
  • HENRY F. EDELHAUSER
    Departments of Physiology and Ophthalmology, The Medical College of Wisconsin (formerly, Marquette University School of Medicine), Milwaukee, Wis.
  • ROBERT A. HYNDIUK
    Departments of Physiology and Ophthalmology, The Medical College of Wisconsin (formerly, Marquette University School of Medicine), Milwaukee, Wis.
Investigative Ophthalmology & Visual Science June 1974, Vol.13, 457-459. doi:
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      DAVID S. HULL, JAMES E. HINE, HENRY F. EDELHAUSER, ROBERT A. HYNDIUK; Permeability of the Isolated Rabbit Cornea to Corticosteroids. Invest. Ophthalmol. Vis. Sci. 1974;13(6):457-459.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Isolated rabbit corneas were mounted in a perfusion chamber, and the comeal permeability of four tritiated corticosteroids was determined. With the epithelium intact, corneal permeability to dexamethasone sodium phosphate was significantly lower than to prednisolone sodium phosphate, prednisolone acetate, and fluorometholone.

With the epithelium removed, the corneal permeability to dexamethasone sodium phosphate and prednisolone sodium phosphate increased three- to four-fold while the comeal permeability to prednisolone acetate and fluorometholone was unaffected.

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