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Abstract
Isolated rabbit corneas were mounted in a perfusion chamber, and the comeal permeability of four tritiated corticosteroids was determined. With the epithelium intact, corneal permeability to dexamethasone sodium phosphate was significantly lower than to prednisolone sodium phosphate, prednisolone acetate, and fluorometholone.
With the epithelium removed, the corneal permeability to dexamethasone sodium phosphate and prednisolone sodium phosphate increased three- to four-fold while the comeal permeability to prednisolone acetate and fluorometholone was unaffected.