The Effects of Theophylline on Cyclic Adenosine Monophosphate Metabolism in Lymphocytes from Open-Angle Glaucoma Patients

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Abstract

The effects of theophylline on cyclic-AMP metabolism were evaluated in lymphocytes from individuals tested topically with corticosteroids and from patients with open-angle glaucoma. Lymphocyte cyclic-AMP phosphodiesterase activity, and kinetic constants were similar in all groups. Theophylline inhibited the enzyme in all groups at similar concentrations and caused an equal rise in cyclic-AMP levels in lymphocytes from each group. It is concluded that the differential effects of theophylline on inhibition of phytohemagglutinin-stimulated lymphocyte transformation in the tested groups cannot be explained by its effect on cyclic-AMP metabolism.