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THOMAS W. SMITH, DANIEL M. ALBERT, NANCY ROBINSON, BRUCE W. CALNEK, OTTO SCHWABE; Ocular Manifestations of Marek's Disease. Invest. Ophthalmol. Vis. Sci. 1974;13(8):586-592.
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An experimental study of the ocular changes occurring in Marek's disease was carried out. Marek's disease which is induced by a DNA virus, is a disorder that occurs in chickens and related fowl. Ocular involvement is a feature of this disease. In this study the eye changes of Marek's disease were sequentially examined in specific, pathogen-free birds injected with clone purified Marek's disease virus. An infiltration of malignant-appearing lymphoreticular proliferative cells was seen initially in the optic nerves, ciliary nerves, and uvea in birds receiving the virus either intraocularly or systemically. Subsequent infiltration of similar cells occurred throughout the eye.
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