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Abstract
The ability of various ocular tissues to make cyclic-AMP and release it into the media has been determined. The posterior chamber contains little, if any, cyclic-AMP either before or after administration of epinephrine to the rabbit eye; therefore, neither the lens nor the ciliary body contributes to the aqueous humor of the anterior chamber, the cyclic-AMP which correlates with the intraocular pressure response. In vitro, tissues lining the anterior chamber such as the cornea, iris, and sclera-trabecular tissue make cyclic-AMP in response to various agonists and can release cyclic-AMP into the incubation media. Of particular interest, is the response of the sclera-trabecular tissue with contains the cells lining the channels for the outflow of aqueous humor. Cyclic-AMP in this tissue may play a role in the regulation of intraocular pressure.