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STAN L. COLEMAN, SAMUEL CANAAN; The Effects of Cortisone on Pine Pollen-induced uveitis in Guinea Pigs. Invest. Ophthalmol. Vis. Sci. 1962;1(6):751-755.
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Injection of pine pollen into the vitreous of guinea pigs previously sensitized with Freund's adjuvant and pine pollen intradermally and intraperitoneally restdted in a dissemimited granulomatous inflammatory process involving the entire uveal tract. Moderate or large doses of steroids (2 to 8 mg. per kilogram per day of prednisolone) diminished the reaction when given 1 to 2 weeks after the challenge, but caused an increase in severity of the reaction if given during the period of sensitization or immediately after the challenge.
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