December 1962
Volume 1, Issue 6
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Articles  |   December 1962
The Effects of Cortisone on Pine Pollen-induced uveitis in Guinea Pigs
Author Affiliations
  • STAN L. COLEMAN
    Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis, Mo.
  • SAMUEL CANAAN
    Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis, Mo.
Investigative Ophthalmology & Visual Science December 1962, Vol.1, 751-755. doi:
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      STAN L. COLEMAN, SAMUEL CANAAN; The Effects of Cortisone on Pine Pollen-induced uveitis in Guinea Pigs. Invest. Ophthalmol. Vis. Sci. 1962;1(6):751-755.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Injection of pine pollen into the vitreous of guinea pigs previously sensitized with Freund's adjuvant and pine pollen intradermally and intraperitoneally restdted in a dissemimited granulomatous inflammatory process involving the entire uveal tract. Moderate or large doses of steroids (2 to 8 mg. per kilogram per day of prednisolone) diminished the reaction when given 1 to 2 weeks after the challenge, but caused an increase in severity of the reaction if given during the period of sensitization or immediately after the challenge.

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