February 1962
Volume 1, Issue 1
Articles  |   February 1962
The Metabolism of Retinal Pigment Cell Epithelium
Author Affiliations
    Section of Ophthalmology, Department of Surgery, The University of Chicago.
Investigative Ophthalmology & Visual Science February 1962, Vol.1, 111-117. doi:
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      VERA C. GLOCKLIN, ALBERT M. POTTS; The Metabolism of Retinal Pigment Cell Epithelium . Invest. Ophthalmol. Vis. Sci. 1962;1(1):111-117.

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      © ARVO (1962-2015); The Authors (2016-present)

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The uptake of P-32 into phosphorus compounds of retinal pigment epithelium and retina was investigated in vitro. In both tissues, the rate of P-32 uptake into acid-soluble organic phosphorus compounds ivas considerably greater than into phospholipid or nucleic acid. The corresponding uptake into each of the fractions was the same for both tissues. The rate of P-32 uptake into acid-soluble organic phosphorus of retina did not increase ivith incubation time between 1 and 4 hours, but there was a significant increase in rate of uptake by pigment epithelium to a plateau at 3 hours. Addition of 1 mg. diaminodiphenoxyheptane (DDH) to the tissue preparations before incubation caused a profound decrease in P-32 uptake into acidsoluble organic phosphorus at all incubation times, but no significant decrease in P-32 uptake into the corresponding fraction of retina. A specific inhibitory effect on pigment epithelium is indicated at the level of either enzyme or cell membrane activity.


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