June 1963
Volume 2, Issue 3
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Articles  |   June 1963
Repression of Glutaminase I in the Rat Retina by Administration of Sodium-L-Glutamate II
Author Affiliations
  • JEROME K. FREEDMAN
    Section of Ophthalmology, Department of Surgery, The University of Chicago, Chicago, Ill.
  • ALBERT M. POTTS
    Section of Ophthalmology, Department of Surgery, The University of Chicago, Chicago, Ill.
Investigative Ophthalmology & Visual Science June 1963, Vol.2, 252-258. doi:https://doi.org/
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      JEROME K. FREEDMAN, ALBERT M. POTTS; Repression of Glutaminase I in the Rat Retina by Administration of Sodium-L-Glutamate II. Invest. Ophthalmol. Vis. Sci. 1963;2(3):252-258. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Further studies of the retinal glutamate effect have shown that not only is glutaminase I decreased in glutamate-treated rat retinas, but glutamic-aspartic transaminase is significantly increased. Direct competitive inhibition of glutaminase I by glutamate can be demonstrated. However, studies with labeled glutamate show that under the conditions of our experiments, retinal concentrations of glutamate reach, at most, the 10 per cent inhibitory level, and that for only a short time. This increases the likelihood, that the observed, effects are due to repression and induction of enzyme synthesis.

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