February 1963
Volume 2, Issue 1
Articles  |   February 1963
Effect of X-Irradiation on the Development of Immunogenic Uveitis
Author Affiliations
    Immunobiology Branch, Armed Forces Institute of Pathology, Washington, D. C.
Investigative Ophthalmology & Visual Science February 1963, Vol.2, 58-62. doi:https://doi.org/
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      ARTHUR M. SILVERSTEIN; Effect of X-Irradiation on the Development of Immunogenic Uveitis. Invest. Ophthalmol. Vis. Sci. 1963;2(1):58-62. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Rabbits receiving an intravitreal injection of egg albumin develop a spontaneous immunogenic uveitis about 7 days later. If, 24 hours prior to antigen injection, the rabbits are given 450 r of x-irradiation to the body with the eyes shielded, the ocular inflammatory response is suppressed. X-irradiation of the eyes alone with the rest of the body shielded does not inhibit the development of uveitis. These data indicate that in this primary response to antigen, active sensitization of ocular tissues does not occur to any appreciable extent, and. that the inflammatory cells which infiltrate the uveal tract originate extraocularly.


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