Gamma Globulin in Experimental Herpes Simplex Keratitis

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Abstract

The chronic keratitis resulting from the steroid treatment of acute herpes simplex infection of the rabbit cornea was significantly improved by the subconjunctival administration of either human or rabbit gamma globulin, the latter possessing no neutralizing antibody to herpes simplex virus. Virus titrations of this late lesion were consistently negative. The etiological and therapeutic implications of these observations will be discussed. It is suggested they provide additional support to the concept that this chronic inflammatory disease is not related to a continuing virus infection.