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IRVING H. LEOPOLD; Antibiotics and Antifungal Agents Problems and Management of Ocular Infections. Invest. Ophthalmol. Vis. Sci. 1964;3(5):504-511.
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Antibiotic and chemotherapeutic agents employed for ophthalmic therapy can produce local and systemic toxicity. The type and frequency of these side effects and complications can depend on the agents, the dosage and duration of therapy, and the individual susceptibility. The dosage schedule should be selected on the basis of penetration. Agent selection usually must be made without bacteriologic identification of organism. The routes of administration are recommended on the basis of optimal penetration, minimal toxicity, patient tolerance, and clinical experience.
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