August 1964
Volume 3, Issue 4
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Articles  |   August 1964
The Fatty Acid Composition of Human Retinal Vitamin A Ester and the Lipids of Human Retinal Tissue
Author Affiliations
  • SIDNEY FUTTERMAN
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Mass.
  • J. STEVENS ANDREWS
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Mass.
Investigative Ophthalmology & Visual Science August 1964, Vol.3, 441-444. doi:https://doi.org/
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      SIDNEY FUTTERMAN, J. STEVENS ANDREWS; The Fatty Acid Composition of Human Retinal Vitamin A Ester and the Lipids of Human Retinal Tissue. Invest. Ophthalmol. Vis. Sci. 1964;3(4):441-444. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Human retinal tissue synthesized vitamin A ester through reactions associated with the operation of the visual cycle during light adaptation. The ester was isolated by chromotographic procedures and analyzed. The isolated vitamin A ester was found to be a mixture containing saturated and monoenoic C12 to C13 fatty acids. The major components, comprising 90 per cent of the mixture, were vitamin A palmitate, palmitoleate, stearate, and oleate. The fatty acid composition of retinal vitamin A ester differed markedly from that of the human retinal lipids in general. The principal fatty acids of human retinal tissue were palmitic, stearic, oleic, arachidonic, and docosahexaenoic acids. Neither age nor sex appeared to influence the relative abundance of these fatty acids in the retina.

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