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Eiji Sakurai, Yoshito Matsuda, Hironori Ozeki, Noriyuki Kunou, Katsuhisa Nakajima, Yuichiro Ogura; Scleral Plug of Biodegradable Polymers Containing Ganciclovir for Experimental Cytomegalovirus Retinitis. Invest. Ophthalmol. Vis. Sci. 2001;42(9):2043-2048.
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purpose. To evaluate the efficacy of a biodegradable scleral plug containing
ganciclovir (GCV) in a rabbit model of human cytomegalovirus (HCMV)
methods. To develop a rabbit model for HCMV retinitis, HCMV solution was
injected once into the vitreous cavity of pigmented rabbits. The
treated animals were divided into three groups: group A received no
treatment, group B was treated once with GCV solution, and group C was
treated with a scleral plug containing GCV. Rabbits in group B received
an intravitreal injection of GCV solution 1 week after HCMV
inoculation. In group C, the scleral plug containing GCV was implanted
in the vitreous of the rabbits 1 week after HCMV inoculation.
Ophthalmoscopically, vitreoretinal findings in each group were graded
from 0+ to 4+ every week for 4 weeks after HCMV injection.
results. Eyes of group A rabbits showed whitish retinal exudates and vitreous
opacities 3 days after HCMV inoculation. These materials increased
gradually until 3 weeks after HCMV inoculation. Scores for
vitreoretinal lesions were significantly lower in eyes of group B
rabbits compared with those of group A at 1 week after GCV injection
(P < 0.05). However, vitreoretinal inflammation in
eyes of group B rabbits increased again thereafter, and no significant
difference in inflammation between groups A and B was found 2 weeks
after GCV injection. In eyes of group C, scores for vitreoretinal
lesions were significantly lower compared with those in both group A
and group B at 3 weeks after HCMV inoculation (P <
conclusions. The results demonstrated that sustained release of GCV into the
vitreous cavity with biodegradable scleral plugs was effective for the
treatment of experimentally induced HCMV retinitis in
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