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Vivienne C. Greenstein, Haifan Chen, Donald C. Hood, Karen Holopigian, William Seiple, Ronald E. Carr; Retinal Function in Diabetic Macular Edema after Focal Laser Photocoagulation. Invest. Ophthalmol. Vis. Sci. 2000;41(11):3655-3664.
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purpose. To assess the effects of focal photocoagulation on retinal function in
the macular and perimacular areas in patients with diabetes who have
clinically significant macular edema.
methods. Eleven patients were assessed after focal laser treatment. Multifocal
electroretinogram (ERG) and full-field ERG techniques were used to
evaluate the effects of treatment on macular, paramacular, and
peripheral retinal function. A modified visual field technique was used
to obtain local threshold fields. The posttreatment results were
compared with pretreatment results. Changes in local ERG response
amplitudes and implicit times were calculated for each patient and
presented as difference fields. The changes in local ERG responses were
compared with the changes in local field sensitivity.
results. After treatment, the results of the psychophysical tests suggested
little or no change in visual function, but changes in retinal function
were observed with the multifocal ERG technique. Local ERG responses
showed increases in implicit time and decreases in amplitude, compared
with pretreatment values. Timing was affected more than amplitude.
conclusions. The results suggest that focal treatment produces changes in retinal
function, and these changes are not restricted to the treated macular
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