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Thomas A. Ciulla, Alon Harris, Larry Kagemann, Ronald P. Danis, Raj Maturi, Lissa McNulty, Linda M. Pratt, Matthew Xiao, Mark H. Criswell, Dov Weinberger; Transpupillary Thermotherapy for Subfoveal Occult Choroidal Neovascularization: Effect on Ocular Perfusion. Invest. Ophthalmol. Vis. Sci. 2001;42(13):3337-3340.
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© ARVO (1962-2015); The Authors (2016-present)
purpose. To perform a descriptive analysis of the effects on ocular blood flow
of transpupillary thermotherapy (TTT) for occult subfoveal choroidal
neovascular membranes (CNVMs) in age-related macular degeneration
methods. Eleven subjects with occult subfoveal CNVM due to AMD were assessed in
a masked fashion by color Doppler imaging (CDI) within 24 hours before,
24 hours after, and 1 month after undergoing TTT.
results. In the posterior ciliary arteries (PCAs), there were no statistically
significant changes observed in the peak systolic velocity (PSV), end
diastolic velocity (EDV), or resistive index (RI) at 24 hours. At 1
month, the mean EDV decreased 36% (P = 0.0105) and
the mean RI increased 3.8% (P = 0.0305) in the
nasal PCA. Although there was a similar trend in the temporal PCA, the
differences did not reach statistical significance. In the central
retinal artery (CRA), the mean PSV decreased 16%
(P = 0.0137), and the mean EDV decreased 21%
(P = 0.0222) at 24 hours after treatment. There
were no statistically significant differences in the CRA blood flow
indices at 1 month after treatment. In the ophthalmic artery, there
were no statistically significant differences observed in the mean PSV,
EDV, or RI at 24 hours or 1 month after treatment.
conclusions. TTT is associated with transiently decreased volumetric blood flow in
the retinal circulation 24 hours after treatment. In the posterior
ciliary arteries that supply the choroid, there were no changes
observed at 24 hours, but at 1 month, there was a decrease in the mean
EDV and an increase in the RI in the nasal and temporal PCAs, reaching
statistical significance in the nasal PCA only. This study suggests
that TTT could lead to alterations in choroidal blood flow, as assessed
by CDI. Further study is warranted.
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