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Dara Koozekanani, Cynthia Roberts, Steven E. Katz, Ed E. Herderick; Intersession Repeatability of Macular Thickness Measurements with the Humphrey 2000 OCT. Invest. Ophthalmol. Vis. Sci. 2000;41(6):1486-1491.
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purpose. This study was designed to determine intersession repeatability of
measurements of macular thickness made with a commercially available
optical coherence tomography (OCT) system. The images that can be
routinely acquired with the commercial instrument differ significantly
in quality from the images in the literature, which have mostly been
acquired on prototype systems.
methods. Multiple OCT images of the nasal macula were obtained from the right
eye during three independent measuring sessions, using the Humphrey
2000 OCT system (Humphrey, San Leandro, CA). Twenty-six volunteers with
no history of ocular disease participated in this investigation. Eyes
in all subjects were undilated during scan acquisition. Scans were
horizontal, 3 mm long, and through the fovea. Five scans were used from
each session, for a total of 15 scans per subject. Retinal boundaries
were automatically detected using custom software. Statistical software
was used to calculate intersession and intrasession repeatability.
Manual correction was performed on the automatically detected
boundaries, and a second analysis was performed using these boundaries.
results. When no manual correction of boundaries was performed, there were no
significant effects between different sessions (P =
0.529) or between different scans within the same session
(P = 0.509). Average retinal thickness was found to
be 274 ± 17 μm for a 1-mm long region 0.75 mm from the fovea.
Individual scan averages differed from overall patient averages by
0 ± 4.3 μm (99% confidence interval, 11.2 μm).
conclusions. OCT measurements of macular thickness made with the Humphrey 2000 OCT
system are repeatable over different sessions with an expected
variation of less than 11 μm (99% confidence
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