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Shu Kachi, Akio Yamazaki, Jiro Usukura; Localization of Caveolin-1 in Photoreceptor Synaptic Ribbons. Invest. Ophthalmol. Vis. Sci. 2001;42(3):850-852.
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purpose. The purpose of this study is to determine whether caveolin-1 is a
constituent of photoreceptor synaptic ribbons.
methods. Immunoblot assay and electron microscopic immunocytochemistry were used
to localize caveolin-1 in synaptic ribbons.
results. Synaptic ribbons were localized close to the active site of presynaptic
membranes and surrounded by a halo of synaptic vesicles. Immunosignals
of caveolin-1 were clearly detected on the synaptic ribbons in rod and
cone photoreceptors. However, the signal was seen neither on synaptic
vesicles nor on presynaptic plasma membranes.
conclusions. Caveolin-1 is a component protein of synaptic ribbons and may be
involved in the regulation of transmitter
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