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Xiaoming Chen, Kenneth C. Wikler, Peter R. MacLeish; Cone Properties of Retinal Margin Cells in the Monkey (Macaca mulatta). Invest. Ophthalmol. Vis. Sci. 2000;41(8):2019-2022. doi: https://doi.org/.
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purpose. To characterize a cell population in the monkey retinal margin that was
labeled with a cone-specific antibody and to determine the presence of
methods. Retinal whole-mount preparations from infant and adult rhesus monkeys
(Macaca mulatta) were immunolabeled by incubation overnight
with the primary antibodies 7G6, a cone-specific antibody; SV2, a
synaptic-vesicle antibody; and opsin antibodies that recognize either
the short or long/middle wavelength–sensitive opsins.
results. The retinal margin cells labeled by 7G6 lay within 1 mm of the ora
serrata and differed from 7G6-labeled cones in the central retina. The
margin cells possessed a soma, a fiber process, and a terminal
enlargement that lay in the plane of the retina; no outer segment was
discernible. A total of 5400 and 7252 margin cones cells were found in
each of two monkeys. The terminal enlargement and soma of the labeled
margin cells also showed SV2 immunoreactivity. Surprisingly, opsin
immunoreactivity extended throughout the margin cell, which is
consistent with the absence of a discernible outer segment.
conclusions. Cells with immunoreactive cone properties were found in the margin of
the monkey retina. The absence of an outer segment and the presence of
somatic opsin and SV2 are reminiscent of features observed in the
central cones of fetal monkey retinas. These results suggest that a
subpopulation of cones in the retinal margin might fail to mature
completely and thus retain juvenile characteristics into
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