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Desmond Fonn, Rènée du Toit, Trefford L. Simpson, José A. Vega, Ping Situ, Robin L. Chalmers; Sympathetic Swelling Response of the Control Eye to Soft Lenses in the Other Eye. Invest. Ophthalmol. Vis. Sci. 1999;40(13):3116-3121.
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purpose. To compare central corneal swelling and light scatter after 8 hours of
sleep in eyes wearing high- and low-Dk hydrogel lenses and to the
contralateral control eyes.
methods. Twenty neophyte subjects wore a Lotrafilcon A (Dk, 140; Ciba Vision,
Duluth GA) silicone hydrogel lens and an Etafilcon A (Dk, 18; Acuvue;
Vistakon, Jacksonville, FL) 58% water content hydrogel lens of
similar center thickness in random order in the right eye only, for
overnight 8-hour periods. The contralateral nonwearing left eyes served
as controls. Central corneal thickness was measured using an optical
pachometer and light scatter using a Van den Berg stray-light meter
before lens insertion, after lens removal on waking, and every 20
minutes for the next 3 hours.
results. Central corneal swelling induced by the Etafilcon A lens on eye opening
was significantly higher than with the Lotrafilcon A lens (8.66% ±
2.84% versus 2.71% ± 1.91%; P < 0.00001). Light scatter
induced by the Etafilcon A lens on eye opening was significantly higher
than with the Lotrafilcon A lens (46.09 ± 5.62 versus 42.78 ± 6.07 Van den Berg units, P = 0.0078). The
swelling of the control eyes paired with the Etafilcon A lens–wearing
eyes was also slightly but significantly higher than that of the
control eyes paired with the Lotrafilcon A lens-wearing eyes (2.34% ±
1.26% versus 1.44% ± 0.91%; P = 0.0002).
Light-scatter measurements were not significantly different between
control sets of eyes but showed the same trend.
conclusions. In neophyte subjects, corneal swelling of the contralateral control
eyes appears to be influenced by the swelling of the fellow
lens-wearing eyes—that is, the swelling of the contralateral control
eye was significantly lower when there was less swelling of the fellow
eye wearing the high-Dk lens. Although there was no statistically
significant difference in light-scatter measurements between the
control sets of eyes, a trend similar to the corneal swelling results
was observed, which could be used to support the suggestion that this
may be a sympathetic physiological response rather than an unusual
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