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Allison M. McKendrick, Algis J. Vingrys, David R. Badcock, John T. Heywood; Visual Field Losses in Subjects with Migraine Headaches. Invest. Ophthalmol. Vis. Sci. 2000;41(5):1239-1247.
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purpose. To characterize the visual fields of subjects with migraine headaches
using static and temporal modulation perimetry.
methods. Sixteen subjects with migraines (15 with aura, 1 without) and 15
nonheadache controls were tested. Perimetry was conducted 7 days after
the offset of a headache with both static and temporally modulated
targets using the Medmont M-600 automated perimeter (Medmont Pty Ltd.,
Camberwell, Victoria, Australia). Flicker thresholds were measured
using the autoflicker test, which varies flicker rate with
eccentricity. A subset of four subjects with migraines (3 with aura, 1
without) had the temporal tuning characteristics of their loss
evaluated using fixed temporal frequencies (4, 6, 9, 12, and 16 Hz).
results. Field losses were identified with temporal modulation perimetry in 11
of 16 migraine subjects. The majority of these losses occurred in the
presence of normal static thresholds (8/11). The deficits displayed
temporal tuning, being greatest for higher temporal frequencies (≥9
Hz). None of the subjects revealed deficits typical of cortical
lesions. The migraine-without-aura subject displayed a
selective loss to temporally modulated stimuli, which was consistent
with the aura group. This defect altered over time, decreasing for 30
to 40 days but remaining, to a smaller extent, for up to 75 days after
the headache event.
conclusions. Visual dysfunction that is selective for temporally modulated targets
occurs in migraine subjects. The migrainous pattern of dysfunction
shares some features with that identified in early stages of glaucoma
and raises the possibility for a common precortical vascular
involvement in these two conditions.
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