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Gro Oddveig Ness, Helle Lybæk, Jarle Arnes, Eyvind Rødahl; Chromosomal Imbalances in Lymphoid Tumors of the Orbit. Invest. Ophthalmol. Vis. Sci. 2002;43(1):9-14.
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purpose. To identify chromosomal gains and losses in lymphoid tumors of the
orbit and to examine whether such abnormalities are related to orbital
presentation, disease severity, or risk for recurrent disease.
methods. Biopsy specimens from 26 patients were examined by histomorphologic and
immunohistochemical analysis. Lymphomas were classified according to
the Revised European-American Lymphoma Classification. Chromosomal
imbalances were detected by high-resolution comparative genomic
hybridization (CGH). Clinical data were obtained by retrospective
evaluation of medical records.
results. Chromosomal imbalances were detected in 0 of 6 patients with idiopathic
orbital inflammation, 0 of 2 with benign reactive lymphoid hyperplasia,
3 of 3 with highly malignant diffuse large B-cell lymphoma, 4 of 10
with marginal zone B-cell lymphoma, 0 of 1 with chronic lymphatic
leukemia lymphoma, and 1 of 4 with immunocytoma. Among the low-grade
malignancies, chromosomal imbalances were seen in 1 of 9 at stage IAE,
2 of 3 at stage IIE, and 2 of 3 at stage IVE. Chromosomal imbalances
were observed in all primary tumors from the five patients that later
developed recurrent disease. In 14 of 23 imbalances with
intrachromosomal breaks outside the centromere region, the breaks were
present at bands with known fragile sites. No chromosomal imbalances
specific for orbital presentation were detected.
conclusions. Chromosomal imbalances were seen mainly in orbital lymphomas that were
either highly malignant or at an advanced stage. CGH analysis of
orbital lymphomas could be prognostically relevant, but further studies
are required to confirm this notion.
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