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Tanya Blekher, Eric Siemers, Larry A. Abel, Robert D. Yee; Eye Movements in Parkinson’s Disease: Before and After Pallidotomy. Invest. Ophthalmol. Vis. Sci. 2000;41(8):2177-2183.
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purpose. To evaluate the effects of unilateral, stereotactic,
posteroventral pallidotomy on saccadic eye movements in patients with
Parkinson disease (PD).
methods. Eye movements of 31 patients with moderate to advanced PD were recorded
with an infrared system 1 month before and 3 months after pallidotomy.
Two kinds of saccade tasks were used: saccade tasks for eliciting
visually guided saccades and saccade tasks for eliciting internally
mediated saccades (memory-guided, predictive, and anti-saccades).
Latency, accuracy, peak velocity, and other parameters of saccades were
results. Internally mediated saccades were more impaired in patients with
advanced PD compared with those with moderate PD. Pallidotomy did not
affect visually guided saccades. After pallidotomy, the peak saccadic
velocity of internally mediated saccades decreased.
conclusions. Hence, although pallidotomy has led to improvements in other motor
functions, none were observed in saccadic responses. Rather, several
modest decrements, below the level of clinical significance and all in
internally mediated saccades, were observed.
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