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Stefania Bortoluzzi, Fabio d’Alessi, Gian Antonio Danieli; A Novel Resource for the Study of Genes Expressed in the Adult Human Retina. Invest. Ophthalmol. Vis. Sci. 2000;41(11):3305-3308. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
purpose. To reconstruct the transcriptional profile of the human adult retina
and the genomic map of the genes expressed in this tissue.
methods. Original software was used for the retrieval and analysis of records
from UniGene (http://www.ncbi.nlm.nih.gov/UniGene/) pertaining to
selected cDNA libraries from adult human retina.
results. The 4974 genes reported so far to be expressed in retina were included
in a catalog available on the Internet. For each entry, an estimation
of the level of expression of the corresponding gene in the retina was
provided. A high-resolution genomic map of the human retina was built
up by inclusion of 3152 genes showing a precise and unique map
assignment. The correspondence was established between 53 gene–orphan
retinal diseases and clusters of genes expressed in the retina.
conclusions. The in silico reconstruction of the transcriptional profile of the
adult human retina provides preliminary information on the pattern of
genomic expression in this tissue. The chromosomal location of many
retinal genes, combined with their expression data, should speed up the
identification of genes involved in retinal
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