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Alexander T. Kozhich, Chi-Chao Chan, Igal Gery, Scott M. Whitcup; Recurrent Intraocular Inflammation in Endotoxin-Induced Uveitis. Invest. Ophthalmol. Vis. Sci. 2000;41(7):1823-1826.
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purpose. Endotoxin-induced uveitis (EIU) in rats and mice peaks 24 hours after
endotoxin injection and is commonly assumed to be a monophasic disease.
This study examined intraocular inflammation at later time points to
determine whether endotoxin injection can induce recurrent intraocular
inflammation in strains of mice with high or moderate levels of
susceptibility to EIU.
methods. EIU was elicited in two mouse strains with high (C3H/HeN) and moderate
(FVB/N) susceptibility, by means of intraperitoneal injections of
Salmonella typhimurium endotoxin. Inflammatory cells in the
anterior and posterior segments of the eye were counted by a masked
observer on histologic sections of eyes from 1 to 17 days after
results. A bimodal distribution of inflammatory cell infiltration was noted in
eyes from C3H/HeN mice. As previously reported, inflammation peaked at
24 hours after endotoxin injection. However, a second, more pronounced
peak of intraocular inflammation occurred approximately 5 days after
endotoxin injection. FVB/N mice had a single peak of intraocular
inflammation 4 days after injection.
conclusions. Endotoxin injection in C3H/HeN elicits recurrent intraocular
inflammation. The previously unrecognized second peak of inflammation
is more severe than the initial inflammatory disease. Studies on this
second inflammatory peak may be useful in determining the pathogenesis
of recurrent uveitis in humans.
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