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Boel Bengtsson, Anders Heijl; Lack of Long-Term Drift in Timolol’s Effectiveness in Patients with Ocular Hypertension. Invest. Ophthalmol. Vis. Sci. 2001;42(12):2839-2842.
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purpose. To report the change over time in intraocular pressure in patients
treated with topical timolol or placebo.
methods. Ninety patients with untreated ocular hypertension, defined as elevated
intraocular pressure and normal visual fields, were randomly assigned
to treatment and prospectively observed at 3-month intervals for up to
10 years in a double-masked fashion. The study end point was one eye
showing reproducible glaucomatous field defects; patients were also
withdrawn if one eye showed intraocular pressure of 35 mm Hg or higher.
For each treatment group and visit, the mean and median of all
intraocular pressure measurements were calculated. Medians were also
calculated for the timolol group, assuming a worst-case scenario in
which all patients who reached the end point, or intraocular pressure
of 35 mm Hg or more, were assumed to show higher intraocular pressure
than those remaining in the study. Distributions of slopes for
intraocular pressure over time were compared between treatment groups.
results. Means and medians of follow-up intraocular pressure over time did not
differ between timolol- and placebo-treated patients. This was also
true when assuming a worst-case scenario. Slopes of intraocular
pressure over time did not differ statistically between treatment
conclusions. In agreement with other masked and controlled studies and in conflict
with uncontrolled ones, the present study did not demonstrate long-term
drift of intraocular pressure in patients with ocular hypertension
treated with topical timolol.
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