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Tommaso Salgarello, Alberto Colotto, Benedetto Falsini, Luca Buzzonetti, Luca Cesari, Giancarlo Iarossi, Luigi Scullica; Correlation of Pattern Electroretinogram with Optic Disc Cup Shape in Ocular Hypertension. Invest. Ophthalmol. Vis. Sci. 1999;40(9):1989-1997.
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purpose. To evaluate the correlation of pattern electroretinogram (PERG), an
index of inner retinal function, with confocal scanning laser (CSLO)
optic disc structural parameters in ocular hypertension (OHT).
methods. Thirty-four patients with OHT, normal white-on-white (Humphrey 30-2)
perimetry, and normal clinical optic discs were examined with PERG and
CSLO disc analysis. Two groups of normal subjects
(n = 38 and 18, for PERG and CSLO, respectively)
and a group of 12 patients with early open-angle glaucoma (EOAG) were
also tested. Pattern electroretinogram amplitudes were measured in
response to sinusoidal gratings of variable spatial frequency
(0.58–5.8 cycles/degree), modulated in counter–phase at 7.5 Hz.
Morphometric optic disc parameters were obtained by the Heidelberg
Retina Tomograph (HRT), either globally or from predefined disc
sectors. In addition to standard parameters, the cup shape measure, an
index of depth variation and steepness of the cup walls, was
results. In individual OHT patients, PERG amplitudes at 2.6 cycles/degree were
negatively correlated with cup shape measures (r =−
0.43, P < 0.01) obtained from analysis of the
inferotemporal (IT) sector. No significant correlations were found for
the other parameters. On average, the cup shape measures derived from
IT sector or global analysis were significantly (P < 0.01) worse, and closer to the measures of EOAG patients, in OHT
patients with abnormal PERG compared with those with normal PERGs. The
cup shape measure displayed a low sensitivity (20%) and a high
specificity (100%) in predicting PERG abnormalities in individual OHT
conclusions. The results indicate that in OHT there is a significant although weak
correlation between PERG amplitude and the shape of the optic disc cup,
suggesting a parallel involvement of both function and morphology.
Combined PERG and optic disc cup structural analysis is of potential
diagnostic value to detect early damage to optic nerve head in
individual OHT patients.
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