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Vivienne C. Greenstein, Karen Holopigian, Donald C. Hood, William Seiple, Ronald E. Carr; The Nature and Extent of Retinal Dysfunction Associated with Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2000;41(11):3643-3654.
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purpose. To evaluate the nature and extent of retinal dysfunction in the macular
and surrounding areas that occurs in patients with diabetes with
clinically significant macular edema (CSME).
methods. Eleven patients were evaluated before focal laser treatment. Multifocal
electroretinogram (ERG) and full-field ERG techniques were used to
assess the effects of diabetic retinopathy and CSME on macular,
paramacular, and peripheral retinal function. A modified visual field
technique was used to obtain local threshold fields. The relationship
between local sensitivity changes and local ERG changes was determined.
results. Local ERG responses were significantly delayed and decreased in
amplitude, and timing changes were observed in a larger area of the
retina than amplitude changes. Visual field deficits were similarly
widespread with marked sensitivity losses occurring in retinal areas
with normal ERG amplitudes and in areas that appeared to be free of
fundus abnormalities. Despite this similarity and the finding that
retinal areas with elevated thresholds have timing delays, timing
delays were not good predictors of the degree of threshold elevation.
conclusions. The results demonstrate the widespread nature of timing deficits and
visual field deficits that are associated with
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