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Kazuro Yabuki, Nobuhisa Mizuki, Masao Ota, Yoshihiko Katsuyama, Gerasimos Palimeris, Caterina Stavropoulos, Yvonni Koumantaki, Marylin Spyropoulou, Ernestini Giziaki, Virginia Kaklamani, Evangelia Kaklamani, Hidetoshi Inoko, Shigeaki Ohno; Association of MICA Gene and HLA-B*5101 with Behçet’s Disease in Greece. Invest. Ophthalmol. Vis. Sci. 1999;40(9):1921-1926.
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purpose. Behçet’s disease (BD) is known to be associated with HLA-B51 in many different ethnic groups. Recently MICA, a member of a novel family of the human major
histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), was
identified near the HLA-B gene, and a triplet repeat
microsatellite polymorphism was found in the transmembrane (TM) region.
Because a strong association with BD of one particular MICA-TM allele, A6, was shown in a Japanese
population, the present study was conducted to investigate
microsatellite polymorphism in Greek patients with BD to know whether
this association is generally observed in BD occurring in other
methods. Thirty-eight Greek patients with BD and 40 ethnically matched control
subjects were examined for MICA microsatellite polymorphism
using polymerase chain reaction (PCR) and subsequent automated fragment
detection by fluorescent-based technology.
results. Similar to the Japanese patients with BD, the phenotype frequency of
the MICA-TM A6 allele was significantly increased in the
Greek patients with BD (50.0% in control subjects versus 86.8% in BD
cases), with an odds ratio (OR) of 6.60 (P = 0.0012). The MICA-A6 allele was found in a high frequency both in males
and females (weighted OR = 6.68; P = 0.0017). No association was found between the A6 allele and
several disease features. A strong association exists between the MICA-TM A6 allele and the B*5101 allele in both
the control subjects and patients with BD (weighted OR = 44.39; P = 0.0000023).
conclusions. This study revealed in Greek patients a strong association of BD with a
particular MICA-TM allele, MICA-A6, providing
insight into the molecular mechanism underlying the development of
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