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Ray F. Gariano, Anjali K. Nath, Donald J. D’Amico, Thomas Lee, M. Rocio Sierra–Honigmann; Elevation of Vitreous Leptin in Diabetic Retinopathy and Retinal Detachment. Invest. Ophthalmol. Vis. Sci. 2000;41(11):3576-3581.
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purpose. Leptin is a cytokine that regulates energy metabolism and is linked to
diabetes mellitus through its metabolic actions. Leptin is angiogenic
and promotes wound healing, and therefore this investigation was
conducted to determine whether leptin is associated with neovascular
and fibrotic complications of diabetes and other retinopathies.
methods. Serum and vitreous samples were collected from patients classified by
the presence and type of diabetic retinopathy or other ocular diseases.
Leptin was measured in serum and vitreous by radioimmunoassay, and
leptin and leptin receptor were localized in epiretinal membranes
results. Leptin levels in serum and vitreous were higher in patients with
diabetes than in those without, and vitreous leptin concentrations were
especially elevated in patients with proliferative diabetic retinopathy
or retinal detachment. Leptin and leptin receptor were detected in
fibrovascular epiretinal membrane of patients with diabetes.
conclusions. Leptin in human vitreous is elevated in proliferative diabetic
retinopathy, and retinal detachment and is present in fibrovascular
epiretinal tissue. These data suggest an involvement of leptin in
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