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Nigel Philip Davies, Antony Bryan Morland; Color Matching in Diabetes: Optical Density of the Crystalline Lens and Macular Pigments. Invest. Ophthalmol. Vis. Sci. 2002;43(1):281-289.
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purpose. To measure the optical density of the crystalline lens and macular
pigments in a group of patients with diabetes mellitus and compare the
results with those in a group of control subjects.
methods. Color matches were performed using a Wright tristimulus
colorimeter. The reference wavelength used was 490 nm, desaturated with
650 nm. Lens optical density was measured by mixing spectral primaries
of wavelengths 420, 515, and 650 nm to match the reference. Wavelengths
420 and 515 nm were chosen, because they are absorbed equally by the
macular pigment. To measure macular pigment density, two color matches
were performed, one foveal and one 5° extrafoveal. The reference
stimulus was matched by mixing spectral primaries of 460, 530, and 650
nm. The ratio of the foveal to extrafoveal color match gives the
optical density of the macular pigment. Thirty-four diabetic patients
and 34 control subjects performed the lens density color match, and of
these, 26 diabetic patients and 30 control subjects performed the
macular pigment density color matches.
results. There is a significant increase in the optical density of the lens in
diabetes with age in comparison to the control subjects
(P < 0.001), with a duration dependence of 0.02
log units/year. The mean macular pigment density in the diabetic
patients was 0.13 ± 0.20 log units and in the control subjects
0.32 ± 0.24 log units (P = 0.0015). Patients
with grade 2 maculopathy had significantly lower pigment density than
those with no maculopathy (P = 0.016).
conclusions. The ocular media of diabetic persons are abnormal, with increased lens
and reduced macular pigment optical density. The relationship between
reduced macular pigment levels with increasing severity of maculopathy
may implicate oxidative stress as a causative
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