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Jost B. Jonas, Sohan Singh Hayreh; Influence of Experimental Chronic High-Pressure Glaucoma on Age-Related Macular Degeneration in Rhesus Monkeys. Invest. Ophthalmol. Vis. Sci. 2000;41(10):2972-2977.
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purpose. To assess prospectively whether development of age-related macular
degeneration is influenced by experimentally induced chronic
high-pressure glaucoma, and whether age-related macular degeneration
influences the appearance of the optic nerve head in experimental
chronic high-pressure glaucoma in older rhesus monkeys.
methods. The longitudinal study included 102 eyes of 52 rhesus monkeys. The
total study group was divided into a group with experimentally induced
unilateral chronic high-pressure glaucoma (n = 40 eyes)
and a normal control group (n = 62 eyes). Additionally,
arterial hypertension and atherosclerosis were experimentally induced
in both study groups in a similar percentage of monkeys. Mean monkey
age at the end of the study was 19.6 ± 3.1 years (range, 13–24
years). The macular region, optic disc, and retinal nerve fiber layer
were morphometrically evaluated by color wide-angle fundus photographs
taken at baseline and at the end of the study.
results. The degree of age-related macular degeneration, measured as number and
area of drusen in the foveal and extrafoveal region of the macula, did
not differ significantly between the two study groups. In the
glaucomatous group, the degree of macular degeneration was
statistically independent of the development of parapapillary
atrophy, loss of neuroretinal rim, and decrease in the visibility of
the retinal nerve fiber layer.
conclusions. Development of age-related macular degeneration in rhesus monkeys is
independent of concomitant chronic high-pressure glaucoma, including
the development of glaucomatous parapapillary chorioretinal atrophy.
Conversely, age-related macular degeneration does not markedly
influence the course of experimental chronic high-pressure glaucoma or
the development of parapapillary atrophy in
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