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Fion D. Bremner, Elizabeth A. Tomlin, Josephine Shallo–Hoffmann, Marcela Votruba, Stephen E. Smith; The Pupil in Dominant Optic Atrophy. Invest. Ophthalmol. Vis. Sci. 2001;42(3):675-678.
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purpose. To compare visual and pupil afferent function in dominant optic atrophy
methods. Patients with DOA who belonged to families showing evidence of linkage
to the locus on chromosome 3q28-qter were recruited from the Moorfields
Genetic Register. Patients and healthy control subjects underwent
visual and pupil perimetry using a modified automated perimeter
(Octopus 1-2-3; Interzeag, Schlieren, Switzerland). Five stimulus
locations were tested: fixation, and at 17° eccentricity along the
45° and 135° meridians in all four quadrants. The visual deficit
(difference in decibels between the patient’s luminance threshold and
that in age-matched healthy control subjects) was compared directly
with the pupil deficit (difference in decibels between the stimulus
intensity giving the patient’s pupil response and that giving an
equivalent pupil response in healthy control subjects) at each test
results. Visual deficits and pupil afferent deficits were found at all five
locations. The visual deficits were significantly greater than the
pupil deficits at the four peripheral locations (median difference = 6.3 dB, P < 0.001). At fixation, the difference
was not significant (median difference = 2.3 dB, P = 0.407).
conclusions. Pupil function appears less affected than visual function at four of
five locations tested. This result provides evidence that the
retinotectal fibers serving the pupil light reflex are less susceptible
to damage from the OPA1 genetic defect than the
retinogeniculate fibers serving vision.
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