A. Genes Differentially Expressed 3 Hours after ROS Challenge (FDR = 25%) | | | | | | |
Up-regulated genes | | | | | | |
DNA-damage-inducible transcript 3 | DDIT3 | AA015892 | 3.2 | Nuclear | 3.2 | Transcription regulation, stress response |
Hypothetical protein BC011981 | | AA429886 | 2.0 | | | |
Thioredoxin reductase 1 | TXNRD1 | AA453335 | 1.9 | Cytoplasmic | 2.1 | Signal transducation, oxyreductase |
Microtubule-associated protein, RP/EB family, member 1 | MAPRE1 | AA001749 | 1.9 | Associated with the microtubule network | | Cell cycle |
Epimorphin | EPIM | AA056536 | 1.9 | | | Signal transduction |
EST | | AA015718 | 2.6 | | | |
Cyclin-dependent kinase inhibitor 2A | CDKN2A | AA877595 | 1.8 | | | Cell cycle |
Activating transcription factor 4 | ATF4 | AA600217 | 2.3 | Nuclear | 1.9 | Transcription regulation |
Coagulation factor III | F3 | W27765 | 4.1 | | 2.5 | Receptor, signaling, coagulation |
Fibroblast growth factor (acidic) intracellular binding protein | FIBP | AA490046 | 1.6 | Nuclear and cytoplasmic membranes | | Signal transduction |
E3 ubiquitin ligase SMURF2 | SMURF2 | AA479976 | 2.1 | | | Proteolysis regulates the activity of diverse receptor systems |
Jun B proto-oncogene | JUNB | M29039 | 1.9 | | | Transcription regulation |
FOS-like antigen 1 | FOSL1 | BC016648 | 3.1 | Nuclear | 4.2 | Transcription regulation, cell proliferation |
Ribophorin I | RPN1 | AA127100 | 1.8 | Type i membrane protein, endoplasmic reticulum | | Protein modifecation |
Plasminogen activator inhibitor 1 | PAI1 | N75719 | 2.5 | | 3.0 | Proteinase inhibitor, coagulation, inhibitor of vitreonectin intgrin binding, inhibit CNV |
Dual specificity phosphatase 1 | DUSP1 | N62259 | 1.7 | | | Oxidative stress response |
EST | | AA016065 | 2.0 | | | |
CD2 antigen | CD2 | AA927710 | 3.9 | Type i membrane protein | | Receptor, cell adhesion, signal transduction |
Nuclear transcription factor Y, alpha | NFYA | AA412691 | 1.6 | Nuclear | | Transcription regulation |
Insulin-like growth factor binding protein 1 | IGFBP1 | AA777187 | 1.6 | | | Signal transduction cell proliferation |
Hypothetical protein BC014942 | | AA918089 | 1.7 | | | |
EST | | AA709414 | 2.4 | | | |
GK001 protein | | AA004671 | 2.4 | | | |
SWI/SNF related matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 5 | SMARCA5 | AA608512 | 1.8 | | | Transcription regulation |
EST | | AI024521 | 1.7 | | | |
Werner helicase interacting protein | WHIP | AA879105 | 1.8 | | | May influence the aging process |
EST | | R85888 | 1.6 | | | |
Myogenin | MYOG | AI291603 | 1.5 | Nuclear | | Transcription regulation |
Proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | PSMF1 | AA421258 | 1.7 | | | Proteosome inhibitor |
CK2 interacting protein 1 | | AA490216 | 1.8 | | | |
Excision repair cross-complementing rodent repair deficiency, complementation group 1 | ERCC1 | T95289 | 1.9 | Nuclear | | DNA repair |
Hypothetical protein FLJ20986 | | H48097 | 1.6 | | | |
Discs, large (Drosophila) homolog 1 | DLG1 | H24707 | 1.5 | | | Membrane-associated protein with guanylate kinase activity |
Kruppel-like factor 13 | KLF13 | H97677 | 2.9 | Nuclear | | Transcription regulation |
Flotillin 2 | FLOT2 | R73545 | 1.5 | Membrane-associated protein of caveolae | | Cell adhesion |
CD81 antigen | CD81 | AA486653 | 1.9 | Integral membrane protein | | Signal transduction |
EST | | W28791 | 1.6 | | | |
Myelin gene expression factor 2 | | AA598567 | 1.6 | | | Transcription regulation |
Protein tyrosine phosphatase type IVA, member 2 | PTP4A2 | AA504327 | 1.8 | | | Protein modification |
LPS-induced TNF-alpha factor | PIG7 | AA625666 | 1.4 | | | Transcription regulation |
EST | | AA018820 | 1.5 | | | |
Down regulated genes | | | | | | |
Leukotriene A4 hydrolase | LTA4H | AA465366 | −2.5 | Cytoplasmic | 0 | Peptidase, leukotriene metabolism |
KIAA0798 gene product | | H81605 | −3.7 | Nuclear | | |
KIAA0161 gene product | KIAA0161 | W95118 | −17.1 | | | |
Copper chaperone for superoxide dismutase | CCS | N30404 | −2.5 | Cytoplasmic | −1.3 | Intracellular copper delivery |