The HLA genotypes for the study group are given in
Table 2 , and the relative risk (RR) with 95% confidence interval (CI) and probability for HLA antigens with a statistically significant association to TINU syndrome are given in
Table 3 . HLA antigens that were found to be associated with TINU syndrome were HLA-B14 (6/18 patients, 33.3%; control subjects, 5.5%;
P = 0.0003; RR = 8.5), HLA-DQA1*01 (17/18 patients, 94.4%; control subjects, 46.6%,
P = 0.0001; RR = 19.5), HLA-DQB1*05 (14/18 patients, 77.8%; control subjects 17.7%;
P < 0.0001; RR = 16.3), and HLA-DRB1*01 (14/18 patients, 77.8%; control subjects, 12.1%;
P < 0.0001; RR = 25.5). High-resolution molecular typing revealed a significant association between TINU syndrome and HLA-DQA1*0101 (14/18 patients, 77.8%; control subjects 22.2%;
P < 0.0001; RR = 12.2), HLA-DQB1*0501 (13/18 patients, 72.2%; control subjects 12.9%;
P < 0.0001; RR = 17.6), and HLA-DRB1*0102 (13/18 patients, 72.2%; control subjects, 1.6%;
P < 0.0001, RR = 167.1). HLA-DQB1*06 was decreased in patients compared with control subjects (3/18 patients, 16.7%; control subject, 22%), but this did not reach statistical significance.