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OTTO HOCKWIN; Enzyme Activities in Relationship to Age and Phosphorylated Intermediates in Energy Metabolism. Invest. Ophthalmol. Vis. Sci. 1965;4(4):496-501.
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A brief review of the presence and the age-associated changes of enzymatic activities of the lens metabolism is given. A consideration of the data on the activities of some enzymes of different animal species indicates that changes in lens metabolism related to age should be controlled by multiple sampling at intervals of aging over a wide age span rather than at just two ages. Changes in the concentration of many phosphorylated intermediates of carbohydrate metabolism in the lens with increasing age are well known. In some cases the remits may be interpreted to indicate that there might be a "partial block" of glycolysis. The causes of such "partial block" and the experimental advance are discussed.
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