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EDWARD COTLIER, BERNARD BECKER; Topical Corticosteroids and Galactose Cataracts. Invest. Ophthalmol. Vis. Sci. 1965;4(5):806-814.
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Lens changes were followed in galactose-fed rats treated topically with betamethasone to one eye only. Cataractous changes in eyes receiving topical corticosteroids appeared earlier and developed more rapidly than in contralateral untreated eyes or in eyes of galactose-fed rats receiving no steroids. A few of the possible mechanisms of the steroid effects (86Rb uptake, dulcitol accumulation, and aldolase activity) were explored. Although these were altered in galactose-fed animals, no significant differences were noted between the lenses of corticosteroidtreated and contralateral eyes.
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