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EMILY D. MALONEY, HERBERT E. KAUFMAN; Dissemination of Corneal Herpes Simplex. Invest. Ophthalmol. Vis. Sci. 1965;4(5):872-875.
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Some strains of herpesvirus have wider dissemination than others and may penetrate into the eye and multiply in the endothelium without virus persisting in the stroma. In evaluating chemotherapeutic response, both the strain of the virus and the frequency of drug administration are important; less frequent drug administration gives a poorer therapeutic response. The drug in ointment is more effective than the drug in saline or in dimethyl sulfoxide.
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