October 1965
Volume 4, Issue 5
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Articles  |   October 1965
Aqueous Humor Turnover Rates in the Cat I. Effect of Acetazolamide
FRANK J. MACRI; ROBERT L. DIXON; DAVID P. RALL
Author Affiliations
  • FRANK J. MACRI
    Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, and Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Public Health Service, United States Department of Health, Education and Welfare, Bethesda, Md.; Ophthalmology Branch, National Institute of Neurological Diseases and Blindness
  • ROBERT L. DIXON
    Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, and Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Public Health Service, United States Department of Health, Education and Welfare, Bethesda, Md.; Laboratory of chemical Pharmacology, National Cancer Institute
  • DAVID P. RALL
    Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, and Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Public Health Service, United States Department of Health, Education and Welfare, Bethesda, Md.; Laboratory of chemical Pharmacology, National Cancer Institute
Investigative Ophthalmology & Visual Science October 1965, Vol.4, 927-934. doi:
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      FRANK J. MACRI, ROBERT L. DIXON, DAVID P. RALL; Aqueous Humor Turnover Rates in the Cat I. Effect of Acetazolamide. Invest. Ophthalmol. Vis. Sci. 1965;4(5):927-934.

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Abstract

Aqueous humor turnover in the cat eye determined by intracameral injection of inulin-14C was found to be 2.1 per cent per minute, a value which is in close agreement with that reported for other species. The inhibition of aqueous humor formation induced by acetazolamide was dose dependent bid the quantities required were much higher than those reported necessary to lower the eye pressure. The data acquired in these experiments also alloived comparisons to be made between intraocular pressure and (1) anterior chamber volume; and (2) rate of aqueous humor formation. No statistically significant regression was found between the IOP and these two factors. In addition, an experimentally induced rise of IOP did not reflexly decrease the rate of aqueous humor turnover as has sometimes been suggested

Copyright 1965 The Association for Research in Vision and Ophthalmology, Inc.
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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