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JOHN E. HARRIS, BERNARD BECKER; Cation Transport of the Lens. Invest. Ophthalmol. Vis. Sci. 1965;4(4):709-722.
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The lens maintains its cation content by the excretion of sodium and the concentration of potassium. This active transport of cations can be demonstrated in a fairly simple medium. Glucose appears to be the major metabolite supplying energy for transport. The transport of cations demonstrates saturation kinetics and has relatively high Q10 characteristics of active transport systems. Transport can be maintained by anaerobic glycolysis. Of the metabolic inhibitors, transport is most sensitive to iodoacetate. The transport system requires sodium-potassium-activated ATPase as evidenced by sensitivity to ouabain. The major site of transport appears to be across the epithelium of the anterior surface of the lens. It has not been determined whether transport of cations occurs across the fiber membranes.
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