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Ning Cheung, Ronald Klein, Jie Jin Wang, Mary Frances Cotch, Amirul F. M. Islam, Barbara E. K. Klein, Mary Cushman, Tien Yin Wong; Traditional and Novel Cardiovascular Risk Factors for Retinal Vein Occlusion: The Multiethnic Study of Atherosclerosis. Invest. Ophthalmol. Vis. Sci. 2008;49(10):4297-4302. doi: 10.1167/iovs.08-1826.
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purpose. To describe the prevalence of retinal vein occlusion (RVO) and its association with cardiovascular, inflammatory, and hematologic risk factors in a multiethnic cohort.
methods. This was a population-based, cross-sectional study of 6147 participants (whites, blacks, Hispanics, Chinese) from six U.S. communities. RVO was defined from retinal photographs taken from both eyes according to a standardized protocol. Risk factors were assessed from interviews, examinations, and laboratory and radiologic investigations.
results. The prevalence of RVO was 1.1% (0.9% for branch RVO and 0.2% for central RVO) and was similar across different ethnic groups: 0.9% in whites, 1.2% in blacks, 1.2% in Hispanics, and 1.1% in Chinese (P = 0.76). Independent risk factors associated with RVO were hypertension (odds ratio [OR], 2.06; 95% confidence interval [CI], 1.18–3.59), older age (OR, 1.34; 95% CI, 1.00–1.81, per decade increase), less education (OR, 4.08; 95% CI, 2.20–7.54), hypertriglyceridemia (OR, 1.98; 95% CI, 1.10–3.56), renal dysfunction (OR, 1.85; 95% CI, 1.01–3.39), and the presence of retinal arteriovenous nicking (OR, 4.01; 95% CI, 2.06–7.81) and focal arteriolar narrowing (OR, 4.38; 95% CI, 1.44–13.34). RVO was not significantly associated with direct measures of subclinical atherosclerosis (e.g., carotid intima media thickness and coronary artery calcium scores) or markers of inflammation (e.g., C reactive protein, interleukin-6) and endothelial dysfunction (e.g., soluble intercellular adhesion molecule-1) or coagulation (e.g., D-dimer).
conclusions. The prevalence of RVO is similar across different racial/ethnic groups. In the general population, RVO is associated with hypertension, dyslipidemia, and renal dysfunction, but not with atherosclerotic disease, systemic inflammation, and hematologic abnormalities.
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