December 2007
Volume 48, Issue 12
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Index  |   December 2007
2007 Subject Index
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5843-5875. doi:https://doi.org/
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      2007 Subject Index. Invest. Ophthalmol. Vis. Sci. 2007;48(12):5843-5875. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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January pages 1–478 
February pages 479–956 
March pages 957–1434 
April pages 1435–1912 
May pages 1913–2468 
June pages 2469–2946 
July pages 2947–3424 
August pages 3425–3904 
September pages 3905–4382 
October pages 4383–4860 
November pages 4861–5338 
December pages 5339–5876 
A
ABCA4 gene mutations 
homozygosity for novel founder splicing mutation associated with Stargardt-like disease, 4308 
macular pigment and lutein supplementation in diseases with, 1319 
in severe retinopathies in Spanish patients, 985 
Acanthamoeba keratitis, oral immunization for (hamster), 5597 
Accommodation 
dynamics of accommodative facility in myopes, 4375 
infants’ accommodation responses to dynamic stimuli, 949 
pharmacologically manipulated accommodative dynamics (monkey), 323 
in pre-presbyopes with visual impairment, 3888 
spherical aberration changes after lens refilling with silicone oil (pig), 1261 
Acetylcholine, muscarinic receptor subtypes on human cornea and conjunctiva, 2987 
Acetylcholinesterase, in photoreceptor death after photic stress (rat), 1290 
Achromatopsia 
CNGB3, 3864 
congenital, OCT of macula in, 2249 
zebrafish cone photoreceptor–specific promoter and genetic rescue of, 522 
Acid/base transporters in lacrimal gland ductal epithelia (rabbit), 3746 
Acrolein, protective effect of lipoic acid against toxicity induced in RPE cells by, 339 
Actin 
association of fascin 2 with photoreceptor inner segment actin, 1380 
cytoskeletal integrity and MMP-2 activation in TM cells, 2105 
Adeno-associated virus (AAV) vectors 
AAV-mediated expression targeting of rods and cones with human rhodopsin kinase promoter (mouse), 3954 
self-complementary, ocular gene transfer with, 3324 
Adenosine and intercellular calcium wave in corneal endothelial cells, 1518 
Adenosine triphosphate (ATP), purinergic receptor–mediated regulation of lens connexin43, 4177 
Adenoviral infection 
adenovirus type 37 keratitis (mouse), 781 
topical immunoglobulin treatment of viral ocular infection (rabbit), 4171 
Adherence to treatment, pharmacy claims data to study glaucoma medication adherence, 5052 
α-2-Adrenergic agonists, effects of topical clonidine vs. brimonidine on choroidal blood flow and IOP during squatting, 4220 
Adrenergic receptors 
α1- and β1-adrenergic modulation of lacrimal gland function in mouse, 1504 
α2 adrenergic receptor–mediated modulation of cytosolic Ca++ signals in rat retina, 1410 
β-adrenergic receptors in inflammatory marker expression in Müller cells, 5276 
Advanced glycation end products, in glaucoma, 1201 
Aerosol drug delivery during pars plana vitrectomy, 5243 
African-Americans, attitudes about eye examinations, 1989 
Age effects. See also Geriatric population; Pediatric population 
age, blood pressure, and retinal vessel diameter, 557 
age-related decline in parasympathetic nerve fibers in submacular choroid, 479 
age-related differences in experimental S. aureus keratitis (rabbit), 5125 
calpain 3 and age-related cataracts (mouse), 2685 
on connective tissue structure of tree shrew optic nerve, 2134 
contrast sensitivity changes in glaucoma and normal aging, 2115 
contribution of oculometric parameters to refraction by age and ethnicity, 4846 
ferritin H- and L-chains in fiber cell canine and human lenses, 3968 
macular temporal responsiveness in normal aging and ARM, 4811 
omega 3 fatty acids and IOP with age (rat), 756 
restoration of visual responses in aged dystrophic rats after channelopsin-2 gene transfer, 3821 
retinal cellular reorganization during normal aging, 2824 
on visual spatial integration, 2940 
Age-related macular degeneration (AMD) 
anxiety and depression in, 1498 
basal laminar deposit and membranous debris in early AMD, 968 
CFH gene variants, smoking, and AMD risk in Japanese population, 5315 
Chlamydia pneumoniae infection and, 4007 
circulating hematopoietic stem cells in neovascular AMD, 5464 
computer-based test for optimal visual acuity in, 4838 
dendritic and synaptic plasticity of neurons in, 2782 
estrogen receptor α gene polymorphisms associated with, 1012 
genetics of pigment changes and geographic atrophy, 3005 
haplotypes spanning complement factor H gene are protective against, 4277 
heredity of small hard drusen in twins aged 20–46 years, 833 
HPLC measurement of ocular carotenoid levels, 543 
Intelligent Distributed Ontology Consensus System, 2278 
LOC387715 polymorphism and, 1128 
murine Ccl2/Cx3cr1 deficiency results in retinal lesions mimicking, 3827 
prevalence of early and late AMD in rural Northern India, 1007 
pseudophakia and neovascular AMD, 1472 
public health impact of neovascular AMD treatments, 96 
reproducibility of quantitative OCT in, 4300 
and retinal protein modification by 4-hydroxy-2-nonenal, 3469 
scavenger receptors for oxidized lipoprotein in, 1801 
SOD2 knockdown mouse model of early AMD, 4407 
suppression of choroidal neovascularization by ACE inhibition (mouse), 2321 
suprathreshold contrast matching in maculopathy, 3419 
synergies of VEGF inhibition and PDT in, 1767 
visual loss and visual hallucinations in, 1416 
Age-related maculopathy (ARM) 
ERG photostress test in evaluation of retinal function in, 2806 
Inflammatory markers and hemostatic factors in, 1983 
macular temporal responsiveness in normal aging and, 4811 
Åland Island eye disease, caused by novel CACNA1F mutation, 2498 
Albumin 
inhibition of angiogenesis by intraceptor nanoparticles (mouse), 2030 
transcytotic passage through lens epithelial cells, 1237 
Aldehyde dehydrogenase class 1A1 (ALDH1A1), postnatal corneal transparency, keratocyte cell cycle exit and expression of (rabbit), 6274061 
Aldose reductase, in endotoxin-induced uveitis (rat), 4634 
Alkaline phosphatase, in glaucomatous TM, 3184 
Alkylphosphocholines, effect on intraretinal proliferation in RD (rabbit), 1305 
Alprostadil, effects on ocular hemodynamics, 815 
Altitude, high, IOP at, 1622 
Alzheimer’s disease, retinal abnormalities in, 2285 
Amblyopia 
anisometropic, spatial contrast sensitivity in, 3622 
cortical defects in, 1575 
juvenile, perceptual learning and recovery of visual acuity in, 5046 
modeling dose-response in children with, 2589 
prehension deficits in, 1139 
screening and treating, 2084 
second-order optic flow deficits in, 5532 
strabismic, binocular summation of contrast in, 5332 
validation study of VEP Vernier acuity in adults, 4070 
Amniotic membrane 
endostatin generation by limbal epithelial cells on, 644 
fate of limbal epithelial progenitor cells during explant culture on, 605 
sutureless transplantation for ocular surface reconstruction, 1528 
Amyloid precursor protein (APP) and amyloid-β immunoreactivity in glaucomatous mouse retinas, 5085 
Analgesic effects of nepafenac, 182 
Anandamide, endocannabinoids in retinal damage after high IOP-induced ischemia in rats, 2997 
Anatomy 
connective tissue structure of tree shrew optic nerve, 2134 
effects of IVF on structural features of neonatal eyes, 5454 
horizontal rectus muscle anatomy in strabismic monkeys, 2576 
OCT of macular structure in preterm and full-term children, 5207 
sonography and MRI of retrobulbar human optic nerve, 1913 
3-D atlas of corneal shape, 1072 
3-D histomorphometry of early glaucomatous monkey optic nerve head, 5068 
3-D histomorphometry of normal and early glaucomatous monkey optic nerve head, 3195, 4597 
Angiogenesis. See also Neovascularization 
antiangiogenic effect of somatostatin receptor 2 (mouse), 3480 
antiangiogenic effects of bisphosphonates (mouse), 5716 
bevacizumab inhibition of corneal lymphangiogenesis and (mouse), 2545 
15(S)-HETE–induced, role of MEK1 in, 4930 
fractalkine mediation of, 5290 
inhibition by EMD478761 implant, 5184 
inhibition by intraceptor nanoparticles (mouse), 2030 
retinal, HGF in, 1793 
Angiography 
fluorescein 
microperimetry in idiopathic macular telangiectasia, 3788 
quantitative analysis of choroidal neovascularization, 349 
focal macular ERG and angiographic findings after PDT, 2254 
topographic, in classic and occult choroidal neovascularization, 1751 
Angiotensin-converting enzyme inhibitors, suppression of choroidal neovascularization by (mouse), 2321 
Angiotensin II and receptor 
angiotensin II type 1 receptor/NF-κB pathway in diabetes-induced retinal inflammation (mouse), 4342 
subtypes in human retina, 3301 
Animal models 
AAV-mediated expression targeting of rods and cones with human rhodopsin kinase promoter (mouse), 3954 
absence of 4–1BB gene function and lacrimal gland inflammation (mouse), 4608 
acetylcholinesterase in photoreceptor death after photic stress (rat), 1290 
acute superior oblique palsy 
change in static eye alignment in (monkey), 2602 
changes in dynamic properties during vertical saccades (monkey), 2612 
relationship to Listing’s law (monkey), 2621 
adenovirus type 37 keratitis (mouse), 781 
age-related differences in experimental S. aureus keratitis (rabbit), 5125 
aldose reductase in endotoxin-induced uveitis (rat), 4634 
α1- and β1-adrenergic modulation of lacrimal gland function in mouse, 1504 
α2 adrenergic receptor–mediated modulation of cytosolic Ca++ signals in rat retina, 1410 
angiotensin II type 1 receptor/NF-κB pathway in diabetes-induced retinal inflammation (mouse), 4342 
antiangiogenic effect of somatostatin receptor 2 (mouse), 3480 
antiangiogenic effects of bisphosphonates (mouse), 5716 
antiscarring effects of Y-27632 in glaucoma filtration surgery (rabbit), 5549 
apolipoprotein A-I and E in developing mouse retina, 1815 
APP and amyloid-β immunoreactivity in glaucomatous mouse retinas, 5085 
atorvastatin inhibition of choroidal neovascularization (mouse), 1839 
axonal transport and cytoskeletal changes with elevated IOP (pig), 3632 
bacterial DNA confers neuroprotection after optic nerve injury (mouse and rat), 3441 
bacterial transcytosis across conjunctival M cells (guinea pig), 2172 
BDNF in retinal protection against light damage–mediated stress (mouse), 2877 
bestrophin mutations in canine multifocal retinopathy, 1959 
N-cadherin expression in retinal detachment and reattachment (rat), 1832 
calcitriol inhibits retinal neovascularization (mouse), 2327 
calpain 3 and age-related cataracts (mouse), 2685 
capillary degeneration in ischemia/reperfusion injury (rat), 361 
carbonic anhydrase inhibitor–induced relaxation of porcine retinal arterioles, 4688 
caspase-dependent apoptosis in retinal degeneration (rat), 2753 
CCR1 deletion prolongs corneal allograft survival (mouse), 1228 
CD18 integrins and neutrophil–keratocyte interactions during corneal wound healing (mouse), 5023 
cellular response to photoreceptor death in murine RD, 849 
ceruloplasmin upregulation in glaucoma (mouse), 727 
changes in pericytes and smooth muscle cells in ROP (kitten), 1368 
characteristics of progenitor cells from ciliary body in mouse, rat, and human eyes, 1674 
chemokine profile and autoimmune pathology in genetic IFN-γ deficiency (mouse), 4616 
chondroitin sulfate-derived disaccharide protects retinal cells from elevated IOP (rat), 1181 
choroidal regulation of scleral glycosaminoglycan synthesis during recovery from induced myopia (chick), 2957 
clearance of intravitreal voriconazole (rabbit), 2238 
CNTF-induced cellular changes in murine RP, 1389 
CNTF reduces vision in rats in dose-dependent manner, 5756 
complement factor D and photoreceptor susceptibility to light-induced damage (mouse), 5282 
cone loss with impaired choroidal circulation after light exposure (rat), 1864 
connective tissue structure of tree shrew optic nerve, 2134 
connexins and lens epithelial cell proliferation (mouse), 5630 
controlling RPE injury after experimental retinal detachment (mouse), 1348 
corneal epithelial changes in diabetic Goto-Kakizaki rat, 590 
corneal virulence of Candida albicans strains deficient in Tup1-regulated genes (mouse), 2535 
cross-axis eye movements in primates with A pattern strabismus, 665 
γD-crystallin–associated protein aggregation and lens fiber cell denucleation (mouse), 3719 
cultivated corneal endothelial cell sheet transplantation (monkey), 4519 
CX3CR1 mediates homing of MHC class II–positive cells to mouse corneal epithelium, 1568 
cyclic ADP-ribose–dependent calcium signaling pathway in bovine rod outer segments, 978 
dacryoadenitis in IL-4 deficient MRL/MpJ mice, 5624 
density and distribution of neuromuscular junctions in normal and botulinum toxin–treated EOMs (rabbit and monkey), 3594 
differential sensitivity of cones to iron-mediated oxidative damage (mouse), 438 
differentiation of retinal stem cells transplanted into murine RP models, 446 
DNase IIβ in mouse lens, 5638 
downregulation of endotoxin-induced uveitis by intravitreal VIP encapsulated in liposomes (rat), 3230 
effect of 15-keto latanoprost on IOP and aqueous humor dynamics (monkey), 4143 
effect of alkylphosphocholines on intraretinal proliferation in RD (rabbit), 1305 
effect of ocular hypertension on retinal nitridergic pathway activity (rat), 2127 
effect of spectral characteristics of Ganzfeld stimuli on photopic negative response of ERG (monkey), 4818 
effect of transcorneal electrical stimulation in acute-phase optic nerve injury (rat), 2356 
effects of foveal ablation on emmetropization and form-deprivation myopia (monkey), 3914 
effects of intravitreous bevacizumab on neovascularization (rabbit), 5708 
effects of topical Y-39983 on ocular tissues in rabbits and monkeys, 3216 
endocannabinoids in retinal damage after high IOP-induced ischemia in rats, 2997 
endogenous TNFα suppression of neovascularization in corneal stroma (mouse), 3051 
endoplasmic reticulum stress activation in degenerating photoreceptors (mouse), 5191 
EPA prevents choroidal neovascularization in mice, 4328 
EphB2 and ephrin-B2 upregulation at optic nerve head in glaucomatous mice with axon loss, 5567 
evaluation of novel dry eye model (rabbit), 4468 
evaluation of retinal status using chromatic pupil light reflex activity (dog), 5178 
expression of Th-1 chemokines and receptors in mouse model of dry eye, 2561 
expression profiling of retinoschisin-deficient retina in postnatal mouse development, 891 
fascicular specialization in human and monkey rectus muscles, 3089 
ferritin H- and L-chains in fiber cell canine and human lenses, 3968 
flash-induced light reflectance changes in macaque retina, 2903 
form-deprivation myopia in chick and retinal gene expression, 3430 
function of visual arrestins in rod photoreceptors (mouse), 1968 
functional assessment of subretinal prosthetic (rat), 916 
gas jets in pneumatic retinopexy (pig), 2734 
GDNF stimulation of rods and dopaminergic amacrine cells (chick), 5306 
gene expression analysis of photoreceptor cell loss in Bbs4-knockout mice, 3329 
gene expression in experimental glaucoma and optic nerve transection (rat), 5539 
gene expression profiling of zebrafish embryonic RPE, 881 
genetic ablation of cone photoreceptors and retinal fold elimination in rd7 mouse, 2799 
genetic determinant of retinal degeneration on mouse chromosome 6, 405 
genetics and susceptibility to oxygen-induced retinopathy (rat), 1761 
glial contributions to retinal detachment–induced photoreceptor degeneration (mouse), 2760 
glycosaminoglycan levels in tree shrew sclera during induced myopia development and recovery, 2947 
GNPTAB deficiency (mouse), 5221 
HDL transport of lutein into retina (chick), 4226 
high-resolution manganese-enhanced MRI of experimental ROP (rat), 4733 
histogenesis of intravitreal membrane and secondary vitreous (mouse), 1923 
horizontal rectus muscle anatomy in strabismic monkeys, 2576 
horizontal saccade disconjugacy in strabismic monkeys, 3107 
Hsp27 phosphorylation in experimental glaucoma (rat), 4129 
HSV-1–dependent apoptosis in corneal epithelial cells (rabbit), 4980 
hyperoxia and oxygen consumption in detached feline retina, 1335 
IFN-γ modulation of dry eye–induced conjunctival epithelial squamous metaplasia (mouse), 2553 
IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in EAU (mouse), 4153 
impaired apparent ion demand in experimental diabetic retinopathy (rat), 4753 
inducible NOS in diabetic retinopathy (mouse), 5257 
influence of thyroid hormone on lacrimal gland and ocular surface morphology (rat), 3038 
inhibition of angiogenesis by intraceptor nanoparticles (mouse), 2030 
inhibition of diabetic leukostasis and blood–retinal barrier breakdown (mouse), 858 
innervation of tissue-engineered corneal implants (pig), 3537 
iNOS and CMV spread in retina (mouse), 285 
interaction between Tubby-like protein 1 and dynamin-1 (mouse), 2837 
intramembrane determinant of peripherin/rds function for photoreceptor disk morphogenesis (mouse), 2975 
IOP-dependent RCG dysfunction in glaucomatous DBA/2J mice, 4573 
keratan sulfate in developing avian cornea, 3083 
laminins essential for basement membrane integrity (zebrafish), 2483 
late-onset cone degeneration induced by Rds mutation and gene rescue (mouse), 5397 
layer-specific differences in rat EOM M-bands, 1119 
light exposure, photoreceptor degeneration, and AP-1 activation (dog), 4907 
light-scattering and ultrastructure of healed penetrating corneal wounds (rabbit), 157 
linkage mapping of ovine microphthalmia to chromosome 23, 3506 
loss of insulin-mediated vasoprotection (rat), 2350 
LYVE-1–positive macrophages in murine eyes, 2162 
macrophages as determinants of ocular HSV-1 infection in immunized mice, 5605 
manganese-enhanced MRI of choroidal melanoma xenografts (rat), 963 
manganese-enhanced MRI studies of intraretinal ion demand in ocular injury (rat), 3796 
manipulation of MMPs to reduce retinal neovascularization in oxygen-induced retinopathy (rat), 907 
mechanism of retinoblastoma tumor cell death after chemotherapy, radiation, and vascular targeting therapy (mouse), 5371 
melanopsin-dependent persistence and photopotentiation of pupillary responses (mouse), 1268 
memantine effects in diabetic retinopathy (rat), 5152 
microRNAs expressed in mouse eye, 509 
miRNA expression in human and rat retinas, 3962 
mitochondrial oxidative damage and diabetic retinopathy (mouse), 3805 
modeling behavior of uveal melanoma in mouse liver, 2967 
murine Ccl2/Cx3cr1 deficiency results in retinal lesions mimicking human AMD, 3827 
mutant ND4-induced optic neuropathy (mouse), 1 
neural reprogramming in retinal degeneration (mouse), 3364 
neuroprotection in juvenile rat model of light-induced retinopathy, 2311 
neuroprotective effect of erythropoietin on RGCs in glaucoma mice, 1212 
neurotrophic factors minimize renal toxicity of verteporfin PDT (rat), 430 
neurotrophins in rat conjunctival goblet cells, 1543 
new mouse model of autoimmune ocular myasthenia gravis, 5101 
new tools for evaluation of toxic ocular surface changes in rat, 5473 
NGF gene therapy improves corneal allograft survival (rat), 1043 
nondestructive quantification of analyte diffusion using OCT (rabbit), 2726 
nonproteolytically activated prorenin in retinal neovascularization (mouse), 422 
novel alternatively spliced isoforms of RTEF-1 in endothelial cells and murine retina, 3775 
novel dendritic cell populations in mouse retina, 1701 
novel form of transducin-dependent RD (mouse), 5445 
OCT and histology of RNFL thickness in glaucoma (monkey), 3645 
ocular hypopigmentation in Rab38cht/cht mice, 3905 
OFF-type blue cone bipolar cell in rabbit retina, 3388 
omega 3 fatty acids and IOP with age (rat), 756 
opsin expression during retinal development in salmonid fishes, 866 
optic nerve head gene expression after exposure to elevated IOP in rat glaucoma model, 3161 
optical imaging of retina activated by suprachoroidal-transretinal stimulation (cat), 4777 
optical zone decentration and aberrations after PRK (cat), 5806 
optomechanical response of human and monkey lenses in a lens stretcher, 3260 
oral immunization for Acanthamoeba keratitis (hamster), 5597 
oscillatory potentials of dark-adapted ERG in ROP (rat), 5788 
oxidative stress and blink-suppressed dry eye (rat), 1552 
panretinal, high-resolution color photography of mouse fundus, 2769 
pathological and electrophysiological features of canine cone–rod dystrophy, 4240 
pattern ERG monitoring of RGC dysfunction in murine glaucoma, 745 
Pax6 expression in pigeon retina, 2503 
Pax6 required for postnatal eye development (mouse), 3292 
PDT and apoptosis in rat choroidal neovascularization model, 4741 
persistent hyperplastic primary vitreous due to somatic mosaic deletion of Arf (mouse), 491 
pharmacologically manipulated accommodative dynamics (monkey), 323 
photoreceptor protection against light damage by heme oxygenase-1 overexpression (rat), 5699 
polylactic acid for visualizing vitreous body during vitrectomy (rabbit), 3277 
posterior pole injury and peripheral RPE proliferation (pig), 355 
postnatal corneal transparency, keratocyte cell cycle exit and expression of ALDH1A1 (rabbit), 6274061 
preclinical safety evaluation of intravitreal VEGF antibody injection (rabbit), 1773 
progressive RGC dysfunction in DBA/2J mouse model of glaucoma, 4564 
prostaglandin FP receptors and 24-hour IOP variation in mice, 2095 
protective effect of basic FGF-impregnated nanoparticles in RCS rats, 3381 
protective effect of TEMPOL derivatives against light-induced retinal damage (rat), 1900 
protective effects of uridine on cornea in rabbit dry eye model, 1102 
proteolytic mechanisms underlying mitochondrial degradation in lens (mouse), 293 
Pseudomonas keratitis in cathelicidin-deficient mice, 4498 
quail retinal carotenoids, 3976 
rapid recruitment of TIP47 in RPE (mouse), 2858 
real-time IOP during LASIK with mechanical microkeratome and femtosecond laser (pig), 68 
reduced photoreceptor damage after PDT through NOS blockade (monkey), 2268 
refractive defects and cataracts in Lim2 null mice, 500 
regional differences in cystine accumulation in rat lens, 1253 
regulation of acid/base transporters in lacrimal gland ductal epithelia (rabbit), 3746 
regulatory T cells enhance retinal graft survival (mouse), 5112 
relationship between RNFL and perimetry measurements (monkey), 763 
relative axial myopia in Egr-1 knockout mice, 11 
restoration of visual responses in aged dystrophic rats after channelopsin-2 gene transfer, 3821 
resveratrol-induced dilation of porcine retinal arterioles, 4232 
Ret activation does not protect from light-induced damage (mouse), 5199 
retinal alterations in zebrafish laminin mutants, 2887 
retinal oxygen metabolism in retinal artery occlusion (rat), 2290 
retinal penetration of bevacizumab after intravitreal injection (monkey), 2814 
retinal toxicity of intravitreal triamcinolone acetonide (rabbit), 390 
retinoblastoma tumor vessel maturation (mouse), 2476 
retinoschisin gene therapy in Rs1h-KO mouse, 3837 
retinoschisin in murine retina, 991 
rod function predicts blood vessel abnormality in ROP (rat), 4351 
role of apoptosis in resolution of experimental autoimmune anterior uveitis (rat), 5091 
role of GLYT2 in glycine uptake in lens core (rat), 5142 
role of macrophage migration inhibitory factor in neovascularization (mouse), 3545 
role of ST2 in Pseudomonas keratitis (mouse), 4626 
RPE65 essential for cone function in NRL-deficient mice, 534 
Schwann cell transplantation preserves vision without immunosuppression (rat), 1906 
selective RPE targeting with laser scanner (rabbit), 1782 
sensitivity to light-induced damage in autosomal dominant retinal disease (mouse), 1942 (erratum, 3436) 
simultaneous defocus integration during refractive development (chick), 5352 
simultaneous fundus imaging and OCT in mouse retina, 1283 
simvastatin-induced dilation of porcine retinal arterioles, 825 
slow-releasing tranilast in PTFE/PLGA after strabismus surgery (rabbit), 699 
SOD2 knockdown mouse model of early AMD, 4407 
somatic ablation of Lrat gene in mouse RPE, 5377 
spantide I in Pseudomonas aeruginosa keratitis (mouse), 797 
spectral-domain OCT for 3D retinal imaging of rodent retina, 1808 
spherical aberration changes after lens refilling with silicone oil (pig), 1261 
Src suppression blocks posterior capsule opacification (chick), 2214 
structural specializations emerging late in mouse lens fiber cell differentiation, 3269 
suppression of choroidal neovascularization by ACE inhibition (mouse), 2321 
suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2 (mouse), 4795 
suppression of experimental autoimmune uveitis by anti-LFA-1α Ab (mouse), 2667 
suppression of mitochondrial oxidative stress in optic neuritis (mouse), 681 
susceptibility of eyes of lower vertebrate to visual environment (tilapia), 4829 
synaptic contact between melanopsin-containing RGCs and rod bipolar cells (rat), 3812 
temporal constraints on experimental emmetropization in infant monkeys, 957 
Th1/Th2 cytokine profile in primary intraocular B-cell lymphoma (mouse), 3223 
3-D histomorphometry of early glaucomatous monkey optic nerve head, 5068 
3-D histomorphometry of normal and early glaucomatous monkey optic nerve head, 3195, 4597 
TNF-α–induced apoptosis in murine CMV retinitis, 1691 
tolerance to retinal ischemia by hypoxic preconditioning (mouse), 1735 
topical immunoglobulin treatment of adenoviral ocular infection (rabbit), 4171 
topotecan vitreous levels after periocular or intravenous delivery for retinoblastoma (rabbit), 3761 
transcorneal electrical stimulation protection of photoreceptors (rat), 4725 
transgenic analysis of rodent anterior ischemic optic neuropathy–induced RGC stress and loss (mouse), 2304 
transgenic corneal neurofluorescence in mice, 1535 
transplantable rabbit carrier-free epithelial sheets, 597 
truncated rhodopsin in rod function and degeneration (moue), 2868 
upregulation of VEGF after retinal scatter laser photocoagulation (mouse), 5677 
valsartan amelioration of retinal dysfunction in diabetic rats, 927 
VEGF in retinal progenitor cell proliferation in murine retinal degeneration, 4315 
visual system vulnerability to prenatal endotoxin exposure (sheep), 472 
wound healing after corneal femtosecond laser keratotomy (rabbit), 2068 
zebrafish cone photoreceptor–specific promoter and genetic rescue of achromatopsia, 522 
Aniseikonia, validity and repeatability of new test for, 58 
Anisometropic amblyopia, spatial contrast sensitivity in, 3622 
Anterior capsular plaque in congenital cataract, 4209 
Anterior chamber angle 
dynamic analysis of dark–light changes with anterior segment OCT, 4116 
measurements by OCT, 3683 
Anti-leukocyte function associated antigen (LFA)-1α Ab, suppression of experimental autoimmune uveitis by (mouse), 2667 
Antifungal therapy, clearance of intravitreal voriconazole (rabbit), 2238 
Antigen-presenting cells in fresh and cultured human corneas, 4459 
Anti–glycoproteins D and K IgGs in herpes stromal keratitis, 2185 
Antihypertensive therapy 
bimatoprost, prostamide activity, and conventional drainage, 4107 
effect of 15-keto latanoprost on IOP and aqueous humor dynamics (monkey), 4143 
effects of topical clonidine vs. brimonidine on choroidal blood flow and IOP during squatting, 4220 
effects of topical Y-39983 on ocular tissues in rabbits and monkeys, 3216 
in vitro studies of antiglaucomatous prostaglandin analogues, 4123 
Antimicrobial therapy 
mass treatment of trachoma and ocular Chlamydia trachomatis, 1492 
phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops vs. 0.3% tobramycin eye drops for bacterial conjunctivitis, 3425 
photoreceptor protective effect of minocycline, 412 
Antioxidants 
gene therapy in optic neuritis (mouse), 5360 
lutein and zeaxanthin protect photoreceptors from oxidative stress–induced apoptosis, 5168 
Antiproliferative drugs, modulation of cholesterol homeostasis in pterygium fibroblasts, 3450 
Anxiety and depression in AMD, 1498 
AP-1 activation, light exposure, photoreceptor degeneration and (dog), 4907 
APITD1 expression and uveal melanoma, 4919 
Apolipoprotein A-I and E in developing mouse retina, 1815 
Apoptosis and cell death 
acetylcholinesterase in photoreceptor death after photic stress (rat), 1290 
antiapoptotic effects of thymosin β-4 on corneal epithelial cells, 27 
apoptotic response of HSV-1 in corneal epithelial cells, 789 (erratum, 1000) 
Bcl-xL in survival of RPE cells, 3846 
bortezomib-induced apoptosis in human retinoblastoma cell lines, 4706 
calpains in RGC death, 5420 
CaMKIIαB mediates survival response in RGCs, 3854 
caspase-8–mediated apoptosis in RPE cells, 3341 
caspase-dependent, in retinal degeneration (rat), 2753 
cellular response to photoreceptor death in murine RD, 849 
cytotoxicity evaluation of different vegetable oil vectors, 5000 
HSV-1–dependent apoptosis in corneal epithelial cells (rabbit), 4980 
IFN-α and IFN-γ sensitize Tenon fibroblasts to mitomycin-C, 3655 
light exposure, photoreceptor degeneration, and AP-1 activation (dog), 4907 
light-induced, 40 
lutein and zeaxanthin protect photoreceptors from oxidative stress–induced apoptosis, 5168 
mechanism of retinoblastoma tumor cell death after chemotherapy, radiation, and vascular targeting therapy (mouse), 5371 
NF-κB and MAPKs in photoreceptor apoptosis, 4766 
optineurin mutant induces death of RGCs, 1607 
p53 expression and lens apoptosis after UV radiation exposure (rat), 4187 
PDT and apoptosis in rat choroidal neovascularization model, 4741 
plasminogen activators cause death of RGCs, 1884 
protective effect of caffeine against UV-induced apoptosis in corneal epithelial cells, 652 
role in resolution of experimental autoimmune anterior uveitis (rat), 5091 
sodium 4-phenylbutyrate corrects myocilin misfolding and rescues cells from, 1683 
TNF-α–induced apoptosis in murine CMV retinitis, 1691 
Aquaporin-1–independent microvessel proliferation in murine oxygen-induced retinopathy, 4802 
Aqueous humor 
bimatoprost, prostamide activity, and conventional drainage, 4107 
effect of 15-keto latanoprost on IOP and aqueous humor dynamics (monkey), 4143 
Arf gene, persistent hyperplastic primary vitreous due to somatic mosaic deletion of (mouse), 491 
Arrestins, function in rod photoreceptors (mouse), 1968 
Asian populations 
CFH gene variants, smoking, and AMD risk in Japanese population, 5315 
gene mutations in Japanese patients with Norrie disease and familial exudative vitreoretinopathy, 1276 
Heidelberg Retina Tomograph of optic disc and RNFL in Singapore children, 4939 
IL-1 gene cluster polymorphisms and glaucoma in Chinese subjects, 2123 
imaging comparison of optic disc and RNFL in glaucoma detection, 2644 
Liwan Eye Study, slit lamp–simulated oblique flashlight test in Chinese eyes, 5459 
ocular dominance, laterality, and refraction in Singaporean children, 3533 
Shihpai Eye Study, correctable visual impairment in elderly Taiwanese, 1032 
208delG mutation in FSCN2 in Chinese individuals, 530 
visual acuity measurement in Chinese reading population, 2383 
D-β-Aspartic acid–containing proteins, localization in human eyes, 3923 
Aspartyl proteinases in Candida albicans keratitis (mouse), 3559 
Astigmatism, in 12-year-old Australian children, 73 
Astrocytes 
Endothelin-1–mediated signaling in expression of MMPs and TIMPs in, 3737 
population differences in elastin maturation in optic nerve head and, 3209 
Atorvastatin, inhibition of choroidal neovascularization by (mouse), 1839 
Atropine, pharmacologically manipulated accommodative dynamics (monkey), 323 
Axenfeld-Rieger syndrome, genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma with FOXC1 and PITX2 mutations, 228 
Azithromycin, phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops vs. 0.3% tobramycin eye drops for bacterial conjunctivitis, 3425 
B
Basal laminar deposit and membranous debris in early AMD, 968 
Basement membrane 
composition of infant vs. adult human corneal basement membranes, 4989 
laminins essential for integrity of (zebrafish), 2483 
Bazan, Nicolas G., 2007 recipient of Proctor Medal, 4864 
Bcl-xL in survival of RPE cells, 3846 
Bell’s palsy, blink recovery in, 203 
Benzalkonium chloride–induced dephosphorylation of myosin light chain in corneal epithelial cells, 2001 
Best disease 
bestrophin mutations in canine multifocal retinopathy, 1959 
macular and peripheral expression of bestrophin, 3372 
Bestrophin 
chloride channel activity of bestrophin mutants causing macular degeneration, 4694 
macular and peripheral expression of, 3372 
mutations in canine multifocal retinopathy, 1959 
Bevacizumab 
inhibition of corneal angiogenesis and lymphangiogenesis (mouse), 2545 
intravitreous, effects on neovascularization (rabbit), 5708 
retinal penetration after intravitreal injection (monkey), 2814 
Bietti’s crystalline dystrophy, genotype–phenotype analysis in patients with CYP4V2 mutations, 5212 
Bilberry anthocyanins, in oxidative stress defense, 2343 
Bimatoprost 
bimatoprost, prostamide activity, and conventional drainage, 4107 
cannabinoid receptors and bimatoprost-induced contractions of ciliary muscle, 3677 
Binocular vision 
immaturities limiting infant binocular stereopsis, 1424 
variation of binocular–vertical fusion amplitude with convergence, 1592 
Biomaterials 
functional assessment of subretinal prosthetic (rat), 916 
laser-activated solder for sealing corneal wounds, 1038 
photo cross-linkable biodendrimers as ophthalmic adhesives, 2037 
polylactic acid for visualizing vitreous body during vitrectomy (rabbit), 3277 
transplantable rabbit carrier-free epithelial sheets, 597 
Biometry 
of Caucasian and African-American cataractous pediatric eyes, 4671 
contribution of oculometric parameters to refraction by age and ethnicity, 4846 
Biomicroscopy, OCT vs. stereoscopic fundus photography or biomicroscopy for diagnosing diabetic macular edema, 4963 
Bisphosphonates, antiangiogenic effects of (mouse), 5716 
Blinking 
effect on tear dynamics, 3032 
recovery in Bell’s palsy, 203 
Blood flow 
effect of topical diclofenac on choroidal blood flow in postoperative pseudophakias, 5647 
effects of pentoxifylline and alprostadil on ocular hemodynamics, 815 
effects of topical clonidine vs. brimonidine on choroidal blood flow and IOP during squatting, 4220 
nitric oxide in choroidal blood flow regulation during light/dark transitions, 4215 
regulation of choroidal blood flow during changes in IOP, 3768 
vascular reactivity in diabetic retinopathy, 1744 
Blood pressure 
age, blood pressure, and retinal vessel diameter, 557 
regulation of choroidal blood flow during changes in IOP and arterial blood pressure, 3768 
retinal arteriole diameter and, 328 
Blood–retinal barrier 
inducible NOS in diabetic retinopathy (mouse), 5257 
inhibition of diabetic leukostasis and breakdown of (mouse), 858 
progression of diabetic macular edema, 3983 
Blue Mountains Eye Study 
Chlamydia pneumoniae infection and AMD, 4007 
Inflammatory markers and hemostatic factors in ARM, 1983 
Blur adaptation in emmetropia and myopia, 2932 
Bone marrow–derived cells 
expression of RPE cell markers, 4321 
in substantia propria of conjunctiva, 4476 
Bone morphogenetic proteins (BMPs) 
activation of BMP canonical signaling pathway, 5058 
BMP-7 inhibits uveal melanoma growth, 4882 
BMP-7 is antagonist of TGF-β2 in TM cells, 715 
effects of TGF-β2, BMP-4, and gremlin in TM, 1191 
Botulinum toxin, density and distribution of neuromuscular junctions in normal and botulinum toxin–treated EOMs (rabbit and monkey), 3594 
Bradykinin, in suppression of choroidal neovascularization by ACE inhibition (mouse), 2321 
BRAF gene, T1799A mutation in iris melanoma, 4897 
Brain 
bidirectional modulation of primary visual cortex excitability, 5782 
cortical defects in amblyopia, 1575 
residual visual function after loss of both cerebral hemispheres in infancy, 3098 
retinotopic organization of primary visual cortex in glaucoma, 733 
Brain-derived neurotrophic factor (BDNF), in retinal protection against light damage–mediated stress (mouse), 2877 
Brightness sensitivity and color perception as predictors of relative afferent pupillary defect, 3616 
Brilliant blue G (BBG), intracellular events in retinal glial cells exposed to ICG and, 4426 
Brimonidine, effects of topical clonidine vs. brimonidine on choroidal blood flow and IOP during squatting, 4220 
British Infantile and Childhood Glaucoma Eye Study, 4100 
C
c-Met and EGFR in RPE wound healing, 2242 
CACNA1F gene, novel mutation causes Åland Island eye disease, 2498 
Cadherins 
N-cadherin expression in retinal detachment and reattachment (rat), 1832 
TGF-β1 repression of E-cadherin via Slug expression in lens epithelium, 2708 
Caffeine, protective effect against UV-induced apoptosis in corneal epithelial cells, 652 
Calcitriol, inhibition of retinal neovascularization by (mouse), 2327 
Calcium 
adenosine and intercellular calcium wave in corneal endothelial cells, 1518 
α2 adrenergic receptor–mediated modulation of cytosolic Ca++ signals in rat retina, 1410 
cyclic ADP-ribose–dependent calcium signaling pathway in bovine rod outer segments, 978 
thrombin inhibition of intercellular Ca2+ wave propagation in corneal endothelial cells, 120 
TRPC channels mediate basal calcium entry in RPE cells, 5767 
Calpains 
calpain 3 and age-related cataracts (mouse), 2685 
in RGC death, 5420 
CaMKIIαB mediates survival response in RGCs, 3854 
Candida  
corneal virulence of Candida albicans strains deficient in Tup1-regulated genes (mouse), 2535 
secreted aspartyl proteinases in Candida albicans keratitis (mouse), 3559 
virulence in keratomycosis (mouse), 774 
Canine multifocal retinopathy, bestrophin mutations in, 1959 
Cannabinoid receptors and bimatoprost-induced contractions of ciliary muscle, 3677 
Capillary degeneration in ischemia/reperfusion injury (rat), 361 
Carbonic anhydrase inhibitor–induced relaxation of porcine retinal arterioles, 4688 
Carbonic anhydrase IV gene mutation and RP, 3459 
Carboxymethylcellulose, in corneal epithelial wound healing, 1559 
Carotenoids 
dietary, macular pigment optical density and, 571 
HPLC measurement of ocular levels of, 543 
identification of 3-methoxyzeaxanthin in macula, 1435 
from quail retina, 3976 
Caspases 
activation by 7-ketocholesterol in retinal neurosensory cells, 1362 
caspase-8–mediated apoptosis in RPE cells, 3341 
caspase-dependent apoptosis in retinal degeneration (rat), 2753 
PDT and apoptosis in rat choroidal neovascularization model, 4741 
Cataract 
atopic, interferon gamma receptor 1 polymorphisms and, 583 
biometry of Caucasian and African-American cataractous pediatric eyes, 4671 
calpain 3 and age-related cataracts (mouse), 2685 
congenital 
anterior capsular plaque in, 4209 
homozygous CRYBB1 deletion in, 2208 
γD-crystallin–associated protein aggregation and lens fiber cell denucleation (mouse), 3719 
degradation of C-terminal αA-crystallins in, 4200 
genetic heterogeneity in microcornea-cataract, 3937 
INDEYE Feasibility Study, prevalence of lens opacities in North India, 88 
in vitro generation of functional lens-like structures, 1245 
lens epithelial cell response to quercetin and DMSO, 3714 
light scattering predicted from particles in nuclear cataracts using Mie scattering theory, 303 
rarebit perimetry, 5320 
and refractive defects in Lim2 null mice, 500 
retinoic acids and cataractogenesis, 2224 
visual adaptation to interocular brightness differences, 935 
Cataract surgery 
lens cell survival in stressed capsular bag, 2701 
pseudophakia and neovascular AMD, 1472 
Src suppression blocks posterior capsule opacification (chick), 2214 
β-Catenin, and epithelial–mesenchymal transition in pathogenesis of pterygium, 1511 
Cathelicidin-deficient mice, Pseudomonas keratitis in, 4498 
Cathepsin, endostatin generation by MMP and cathepsin from limbal epithelial cells on amniotic membrane, 644 
Ccl2/Cx3cr1 deficiency in mouse results in retinal lesions mimicking human AMD, 3827 
CCR1, deletion prolongs corneal allograft survival (mouse), 1228 
CD8 cells 
in experimental autoimmune uveitis (mouse), 2178 
modulation of CD8+ cytotoxic T lymphocyte effector function by fibroblasts derived from immunoprivileged cornea (mouse), 2194 
CD18 integrins and neutrophil–keratocyte interactions during corneal wound healing (mouse), 5023 
CD44, lactate causes NF-κB activation and CD44 shedding in cultured TM cells, 1615 
Cell cycle, Pax6 p46 overexpression induces mitosis defect, 5408 
Cell death. See Apoptosis and cell death 
Cell junction–related proteins, in gelatinous drop-like corneal dystrophy, 1095 
Central retinal venous occlusion, hyperhomocysteinemia and low methionine stress as risk factors for, 1441 
CERKL mutation, in autosomal recessive RD among Yemenite Jews, 5431 
Ceruloplasmin, upregulation in glaucoma (mouse), 727 
Channelopsin-2 gene transfer, restoration of visual responses in aged dystrophic rats after, 3821 
Charles Bonnet syndrome, 1416 
Chemokines and receptors 
CCR1 deletion prolongs corneal allograft survival (mouse), 1228 
chemokine profile and autoimmune pathology in genetic IFN-γ deficiency (mouse), 4616 
CX3CR1 mediates homing of MHC class II–positive cells to mouse corneal epithelium, 1568 
CXCR3 effects in HSV-infected mice, 4162 
expression of Th-1 chemokines and receptors in mouse model of dry eye, 2561 
fractalkine mediation of ocular angiogenesis, 5290 
mitomycin C upregulates chemokine expression in corneal fibroblasts, 2009 
multiplex bead analysis of vitreous humor, 2203 
murine Ccl2/Cx3cr1 deficiency results in retinal lesions mimicking human AMD, 3827 
Chemotherapy, for retinoblastoma 
antitumor action of neurokinin-1 receptor antagonist, 2775 
mechanism of tumor cell death after chemotherapy, radiation, and vascular targeting therapy (mouse), 5371 
paclitaxel treatment in murine model, 3437 
topotecan vitreous levels after periocular or intravenous delivery (rabbit), 3761 
Children. See Pediatric population 
Chinese populations 
IL-1 gene cluster polymorphisms and glaucoma in, 2123 
Liwan Eye Study, slit lamp–simulated oblique flashlight test in Chinese eyes, 5459 
Shihpai Eye Study, correctable visual impairment in elderly Taiwanese, 1032 
visual acuity measurement in reading population, 2383 
Chlamydia pneumoniae infection and AMD, 4007 
Chlamydia trachomatis, ocular 
bacterial infection and trachoma in The Gambia, 4440 
mass treatment of trachoma and, 1492 
Chloride channel activity of bestrophin mutants causing macular degeneration, 4694 
Cholesterol 
HDL transport of lutein into retina (chick), 4226 
modulation of cholesterol homeostasis by antiproliferative drugs in pterygium fibroblasts, 3450 
as treatment for pneumococcal keratitis (rabbit), 2661 
Cholinergic agonists and endotoxin-induced uveitis (rat), 2719 
Chondroitin sulfate-derived disaccharide protects retinal cells from elevated IOP (rat), 1181 
Ciliary body 
characteristics of progenitor cells from (mouse, rat, and human), 1674 
retinal phenotypes in mammalian ciliary body after RGC injury (mouse), 5266 
Ciliary epithelium, fluid transport across, 321 
Ciliary muscle, cannabinoid receptors and bimatoprost-induced contractions of, 3677 
Ciliary neurotrophic factor (CNTF) 
cellular changes in murine RP induced by, 1389 
chemotactic effect on macrophages in RGC survival and axonal regeneration (rat), 4257 
neuroprotection in juvenile rat model of light-induced retinopathy, 2311 
reduction of vision in rats in dose-dependent manner, 5756 
Circadian rhythms 
control of tyrosine phosphorylation of cGMP-gated ion channels in chick photoreceptors, 901 
fluctuation of mean ocular perfusion pressure as risk factor for normal-tension glaucoma, 104 
Clinical trials 
cost-effectiveness of cycloplegic agents in Nigerian children, 1025 
effects of pentoxifylline and alprostadil on ocular hemodynamics, 815 
phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops vs. 0.3% tobramycin eye drops for bacterial conjunctivitis, 3425 
Clonidine, topical, vs. brimonidine on choroidal blood flow and IOP during squatting, 4220 
CNGB3 achromatopsia, 3864 
Coated microneedles for drug delivery, 4038 
Cogan Lecture 
cellular and functional OCT of human retina, 5340 
Wolfgang Drexler, 2007 recipient of Cogan Award, 5339 
Cognitive ability and retinal vascular network geometry in elderly population, 1995 
Collagen 
collagen cross-linking and IOP measurement, 5494 
composition of infant vs. adult human corneal basement membranes, 4989 
loss of α3(IV) collagen in activated corneal keratocytes, 627 
regulation of corneal fibroblasts by ECM mechanical properties, 5030 
second-harmonic imaging microscopy of corneas, 1087 
Color vision 
brightness sensitivity and color perception as predictors of relative afferent pupillary defect, 3616 
CNGB3 achromatopsia, 3864 
gender and color vision defects in asymptomatic carriers of Leber’s hereditary optic neuropathy, 2362 
OCT of macula in congenital achromatopsia, 2249 
zebrafish cone photoreceptor–specific promoter and genetic rescue of achromatopsia, 522 
Complement factor D, and photoreceptor susceptibility to light-induced damage (mouse), 5282 
Complement factor H 
CFH gene variants, smoking, and AMD risk in Japanese population, 5315 
haplotype protection in AMD, 4277 
inflammatory mediators, retinal vessel diameters and polymorphism of, 3014 
Computers 
computer-based test for optimal visual acuity in AMD, 4838 
electronic medical records system for clinical research and the EMR–EDC interface (new developments), 4383 
Cone-rod dystrophy 
ABCA4 mutations in severe retinopathies in Spanish patients, 985 
in vivo imaging of RPE mosaic in diseased retina, 2297 
macular pigment and lutein supplementation in ABCA4 disease, 1319 
Cones. See Photoreceptors 
Confocal microscopy 
bacterial transcytosis across conjunctival M cells (guinea pig), 2172 
corneal innervation and sensitivity in patients with dry eye, 173 
CX3CR1 mediates homing of MHC class II–positive cells to mouse corneal epithelium, 1568 
in vivo confocal study of cornea in Sjögren’s syndrome, 2017 
innervation of tissue-engineered corneal implants (pig), 3537 
ocular dominance, laterality, and refraction in Singaporean children, 3533 
Confocal scanning laser ophthalmoscopy 
diagnostic accuracy in glaucoma, 214 
optic disc measurements in myopia with OCT and, 3178 
repeatability in glaucoma, 1156 
Conjunctiva 
allergic conjunctival inflammation and allogeneic response to donor cornea, 4044 
bacterial transcytosis across M cells of (guinea pig), 2172 
bone marrow–derived cells in substantia propria of, 4476 
comparison of gene expression in human cornea and, 2050 
expression of Th-1 chemokines and receptors in mouse model of dry eye, 2561 
IFN-γ modulation of dry eye–induced conjunctival epithelial squamous metaplasia (mouse), 2553 
muscarinic receptor subtypes on human cornea and, 2987 
neurotrophins in rat conjunctival goblet cells, 1543 
phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops vs. 0.3% tobramycin eye drops for bacterial conjunctivitis, 3425 
regulation of IL-8 by S. aureus in conjunctival cells, 270 
Connexins 
lens epithelial cell proliferation and (mouse), 5630 
purinergic receptor–mediated regulation of lens connexin43, 4177 
Contact lens, measurement of corneal swelling without removal of, 3043 
Contrast sensitivity 
binocular summation of contrast in strabismic amblyopia, 5332 
changes in glaucoma and normal aging, 2115 
in children with infantile spasms, 3610 
effect of myopia on contrast thresholds, 2371 
and higher-order aberrations after orthokeratology, 550 
measured with transient VEP, 3396 
spatial, in anisometropic amblyopia, 3622 
Convergence, variation of binocular–vertical fusion amplitude with, 1592 
Cornea 
activation of prothrombin to form thrombin, 134 
adenovirus type 37 keratitis (mouse), 781 
analgesic effects of nepafenac, 182 
biomechanical properties of cornea, 3026 
Candida virulence in keratomycosis (mouse), 774 
characterization of antigen-presenting cells in fresh and cultured human corneas, 4459 
comparison of gene expression in human conjunctiva and, 2050 
corneal elasticity in damping of IOP, 2540 
corneal virulence of Candida albicans strains deficient in Tup1-regulated genes (mouse), 2535 
endogenous TNFα suppression of neovascularization in corneal stroma (mouse), 3051 
expression of IDO in human corneal cells, 4148 
functional optical zone of, 1053 
genetic heterogeneity in microcornea-cataract, 3937 
impulse activity in corneal sensory nerve fibers after PRK, 4032 
influence of eyelid morphology on corneal shape, 112 
innervation and sensitivity in patients with dry eye, 173 
loss of α3(IV) collagen in activated keratocytes, 627 
measurement of corneal swelling without removal of contact lens, 3043 
mitomycin C upregulates chemokine expression in corneal fibroblasts, 2009 
muscarinic receptor subtypes on human conjunctiva and, 2987 
objective measurement of backscattered light from, 167 
pachymetric mapping with Visante anterior segment-OCT, 5499 
protective effects of uridine in rabbit dry eye model, 1102 
second-harmonic imaging microscopy of, 1087 
3-D atlas of corneal shape, 1072 
TLR-3 and -9 in human corneal myofibroblasts, 3069 
transgenic corneal neurofluorescence in mice, 1535 
UBIAD1 mutations in Schnyder crystalline corneal dystrophy, 5007 
Corneal endothelial cells 
adenosine and intercellular calcium wave in, 1518 
cultivated corneal endothelial cell sheet transplantation (monkey), 4519 
cultured, cryopreservation and genetic modification of, 3056 
isolation, preservation, and expansion of, 614 
JAM-A in RPE and, 3928 
reproducibility of endothelial assessment, 2062 
thrombin inhibition of intercellular Ca2+ wave propagation in, 120 
two semiautomated methods for evaluating endothelial cells of eye bank corneas, 3077 
Corneal epithelial cells 
antiapoptotic effects of thymosin β-4 on, 27 
apoptotic response of HSV-1 in, 789 (erratum, 1000) 
benzalkonium chloride–induced dephosphorylation of myosin light chain in, 2001 
CX3CR1 mediates homing of MHC class II–positive cells to (mouse), 1568 
in diabetic Goto-Kakizaki rat, 590 
expression of Th-1 chemokines and receptors in mouse model of dry eye, 2561 
flagellin pretreatment modulates immune response to Pseudomonas infection, 4664 
functions of MUC16 in, 4509 
HSV-1–dependent apoptosis in, 4980 
inhibition of TGF-β2 production by extracellular matrix, 1061 
notch signaling in differentiation and proliferation of, 3576 
PAF and repressor effect of Sp1 in expression of MMP-9 in, 1931 
PHSRN peptide stimulation of migration of, 1110 
protective effect of caffeine against UV-induced apoptosis in, 652 
Corneal femtosecond laser keratotomy, wound healing after (rabbit), 2068 
Corneal fibroblasts 
localization of ZO-1 in nucleolus of, 2043 
mitomycin C upregulates chemokine expression in, 2009 
modulation of CD8+ cytotoxic T lymphocyte effector function by fibroblasts derived from immunoprivileged cornea (mouse), 2194 
morphology of organized ECM deposition by, 4050 
regulation by ECM mechanical properties, 5030 
Corneal implants, tissue-engineered, innervation of (pig), 3537 
Corneal transplantation 
allergic conjunctival inflammation and allogeneic response to donor cornea, 4044 
CCR1 deletion prolongs allograft survival (mouse), 1228 
corneal innervation and cellular changes after, 621 
episcleral cyclosporine implant for keratoplasty rejection, 2023 
NGF gene therapy improves allograft survival (rat), 1043 
photo cross-linkable biodendrimers as ophthalmic adhesives for, 2037 
Corneal wound healing 
after corneal femtosecond laser keratotomy (rabbit), 2068 
carboxymethylcellulose in, 1559 
CD18 integrins and neutrophil–keratocyte interactions during (mouse), 5023 
in diabetic Goto-Kakizaki rat, 590 
laser-activated solder for sealing corneal wounds, 1038 
light-scattering and ultrastructure of healed penetrating wounds (rabbit), 157 
lysophosphatidic acid and EGFR signaling in, 636 
photo cross-linkable biodendrimers as ophthalmic adhesives for wound repair, 2037 
Cortical defects in amblyopia, 1575 
Cortical organization and optic disc damage in glaucoma, 733 
Corticosteroids 
cytotoxicity of triamcinolone acetonide on RPE cells, 2792 
retinal toxicity of intravitreal triamcinolone acetonide (rabbit), 390 
triamcinolone acetonide effects on leukocyte–endothelium interactions in ischemic retina (rat), 2831 
triamcinolone acetonide-mediated oxidative injury, compared with dexamethasone, 5742 
Cost-effectiveness of cycloplegic agents in Nigerian children, 1025 
CRYAA gene, genetic heterogeneity in microcornea-cataract, 3937 
CRYBB1, homozygous deletion in congenital cataract, 2208 
CRYGD gene, genetic heterogeneity in microcornea-cataract, 3937 
Cryopreservation, and genetic modification of cultured corneal endothelial cells, 3056 
Crystallins 
γD-crystallin–associated protein aggregation and lens fiber cell denucleation (mouse), 3719 
degradation of C-terminal αA-crystallins in cataract, 4200 
target protein sits in fenestrations of α-crystallin, 2695 
Culture studies 
actin cytoskeletal integrity and MMP-2 activation in TM cells, 2105 
activation of BMP canonical signaling pathway, 5058 
adenosine and intercellular calcium wave in corneal endothelial cells, 1518 
β-adrenergic receptors in inflammatory marker expression in Müller cells, 5276 
analysis of RPE cells exposed to REF-1/TFPI-2, 516 
antiapoptotic effects of thymosin β-4 on corneal epithelial cells, 27 
antitumor action of neurokinin-1 receptor antagonist in retinoblastoma, 2775 
apoptotic response of HSV-1 in corneal epithelial cells, 789 (erratum, 1000) 
Bcl-xL in survival of RPE cells, 3846 
benzalkonium chloride–induced dephosphorylation of myosin light chain in corneal epithelial cells, 2001 
bilberry anthocyanins in oxidative stress defense, 2343 
BMP-7 is antagonist of TGF-β2 in TM cells, 715 
c-Met and EGFR in RPE wound healing, 2242 
calpains in RGC death, 5420 
CaMKIIαB mediates survival response in RGCs, 3854 
carboxymethylcellulose in corneal epithelial wound healing, 1559 
caspase-8–mediated apoptosis in RPE cells, 3341 
caspase activation by 7-ketocholesterol in retinal neurosensory cells, 1362 
characterization of antigen-presenting cells in fresh and cultured human corneas, 4459 
circadian control of tyrosine phosphorylation of cGMP-gated ion channels in chick photoreceptors, 901 
cryopreservation and genetic modification of cultured corneal endothelial cells, 3056 
cytotoxicity of triamcinolone acetonide on RPE cells, 2792 
θ-defensin in murine HSV-1 keratitis, 5118 
DHA effect on retinal endothelial caveolae, 18 
double-stranded RNA-dependent protein kinase in ER stress–induced retinal neuron damage, 3729 
ECM gene alternative splicing by TM cells in response to mechanical stretching, 1164 
effect of inflammatory cytokines on RPE proliferation/migration, 5722 
emodin suppression of ocular surface inflammatory reaction, 5013 
endogenous bone marrow–derived cells express RPE cell markers, 4321 
endostatin generation by limbal epithelial cells on amniotic membrane, 644 
endothelin-1–mediated signaling in expression of MMPs and TIMPs in astrocytes, 3737 
expression of IDO in human corneal cells, 4148 
fate of limbal epithelial progenitor cells during ex vivo expansion, 605 
fractalkine mediation of ocular angiogenesis, 5290 
functions of MUC16 in corneal epithelial cells, 4509 
gene expression profiles of donor-matched vascular endothelial cells, 2676 
glucocorticoid receptor activation and signal transduction pathways in lens epithelial cells, 1724 
GM-CSF expression in herpetic stromal keratitis, 277 
gremlin and epithelial-to-mesenchymal transition in PVR, 4291 
histone deacetylase and neuronal differentiation, 2845 
hypoxia-enhanced expansion of limbal epithelial cells, 3586 
identification of RLBP1 gene promotor, 3872 
IGF in RPE cell tractional force generation, 1892 
inhibition of corneal epithelial TGF-β2 production by extracellular matrix, 1061 
in vitro generation of functional lens-like structures, 1245 
intracellular events in retinal glial cells exposed to ICG and BBG, 4426 
intracellular phospholipases A2 in photoreceptor outer segment phagocytosis, 1401 
JAM-A in corneal endothelium and RPE, 3928 
lactate causes NF-κB activation and CD44 shedding in cultured TM cells, 1615 
laminin regulation of α6 integrin gene expression, 3490 
lens cell survival in stressed capsular bag, 2701 
lens epithelial cell response to quercetin and DMSO, 3714 
localization of ZO-1 in nucleolus of corneal fibroblasts, 2043 
loss of α3(IV) collagen in activated corneal keratocytes, 627 
lysophosphatidic acid and EGFR signaling in corneal wound healing, 636 
mechanisms of immune system activation in glaucoma, 705 
miRNA expression in human and rat retinas, 3962 
mitochondrial fission in differentiated RGC-5 cells, 2145 
mitomycin C upregulates chemokine expression in corneal fibroblasts, 2009 
MMP-14 and TIMP-2 overexpression protects against oxidant injury in RPE, 5662 
MMP and TIMP expression in human lens cells, 4192 
morphology of organized ECM deposition by human corneal fibroblasts, 4050 
mutant ND4 induces optic neuropathy (mouse), 1 
notch signaling in corneal epithelial cell differentiation and proliferation, 3576 
novel in vitro model of posterior capsular opacity, 4679 
organ culture and Optisol-GS storage of cultured human limbal epithelial cells, 5484 
oxidative stress in hydrostatic pressure–induced RGC damage, 4580 
PAF and repressor effect of Sp1 in expression of MMP-9 in corneal epithelial cells, 1931 
PDGF-C in proliferative vitreoretinopathy, 2335 
phenotype of limbal epithelial stem cells, 144 
photoreceptor protective effect of minocycline, 412 
plasminogen activators cause death of RGCs, 1884 
positive feedback regulation between MMP-9 and VEGF in RPE cells, 4360 
prevention of excitotoxicity in RGCs by (+)pentazocine, 4785 
protective effect of lipoic acid against acrolein toxicity in RPE cells, 339 
protective effects of caffeine against UV-induced apoptosis in corneal epithelial cells, 652 
protective effects of uridine on cornea in rabbit dry eye model, 1102 
purinergic receptor–mediated regulation of lens connexin43, 4177 
RAGE ligand upregulation of VEGF secretion in ARPE-19 cells, 1355 
regulation of corneal fibroblasts by ECM mechanical properties, 5030 
regulation of IL-8 by S. aureus in conjunctival cells, 270 
reproducibility of endothelial assessment, 2062 
retinoic acids and cataractogenesis, 2224 
Rho-kinase signaling in Tenon’s capsule fibroblasts, 2152 
role of MEK1 in 15(S)-HETE–induced angiogenesis, 4930 
RS1 mutants associated with X-linked retinoschisis, 2491 
secretion of cornea-like tissue in vitro by stem cells, 5038 
sodium 4-phenylbutyrate corrects myocilin misfolding, 1683 
surface bacterial flora in normal and dry eyes, 5616 
surfactant proteins A and D in human tear fluid and lacrimal system, 3945 
synergism of cytokine induction of MMP-3 in TM, 2634 
TGF-β1 repression of E-cadherin via Slug expression in lens epithelium, 2708 
thrombin inhibition of intercellular Ca2+ wave propagation in corneal endothelial cells, 120 
thyroxine-ameliorated oxidative stress in lens epithelial cells, 3698 
tissue transglutaminase expression in subconjunctival fibroblasts, 1952 
TLR-3 and -9 in human corneal myofibroblasts, 3069 
triamcinolone acetonide-mediated oxidative injury, compared with dexamethasone, 5742 
TRPC channels mediate basal calcium entry in RPE cells, 5767 
two spontaneous human Müller cell lines from diabetic donors, 874 
Wnt signaling during photoreceptor degeneration, 5733 
Cyclic ADP-ribose–dependent calcium signaling pathway in bovine rod outer segments, 978 
Cycloplegic agents, cost-effectiveness in Nigerian children, 1025 
Cyclosporine, episcleral implant for keratoplasty rejection, 2023 
CYP1B1, glaucoma-associated mutations in POAG and PACG phenotypes, 5439 
CYP4V2 mutations, genotype–phenotype analysis of Bietti’s crystalline dystrophy in patients with, 5212 
Cystine, regional differences in accumulation in rat lens, 1253 
Cytokeratin 18, as biomarker of early hepatic metastasis from uveal melanoma, 4399 
Cytokines 
dacryoadenitis in IL-4 deficient MRL/MpJ mice, 5624 
DHA effect on retinal endothelial caveolae, 18 
effect of inflammatory cytokines on RPE proliferation/migration, 5722 
endogenous TNF-α suppression of neovascularization in corneal stroma (mouse), 3051 
GM-CSF expression in herpetic stromal keratitis, 277 
IL-1 gene cluster polymorphisms and glaucoma in Chinese subjects, 2123 
multiplex bead analysis of vitreous humor, 2203 
regulation of IL-8 by S. aureus in conjunctival cells, 270 
role of soluble TNF receptors for TNF-α in uveitis, 3246 
synergism of cytokine induction of MMP-3 in TM, 2634 
Th1/Th2 cytokine profile in primary intraocular B-cell lymphoma (mouse), 3223 
TNF-α–induced apoptosis in murine CMV retinitis, 1691 
Cytomegalovirus (CMV) retinitis 
iNOS and CMV spread in retina (mouse), 285 
TNF-α–induced apoptosis in (mouse), 1691 
D
Dacryoadenitis, in IL-4 deficient MRL/MpJ mice, 5624 
Daily Living Tasks Dependent on Vision, Rasch analysis of, 1976 
Decompression-induced ocular tear film bubbles, 3756 
θ-Defensin in murine HSV-1 keratitis, 5118 
Defocus integration during refractive development (chick), 5352 
Dendritic cells 
characterization of antigen-presenting cells in fresh and cultured human corneas using dendritic cell markers, 4459 
novel populations in mouse retina, 1701 
suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2 (mouse), 4795 
Depression and anxiety in AMD, 1498 
Dexamethasone, triamcinolone acetonide-mediated oxidative injury, compared with, 5742 
Diabetes 
angiotensin II type 1 receptor/NF-κB pathway in diabetes-induced retinal inflammation (mouse), 4342 
automated differentiation of drusen, exudates, and cotton-wool spots in digital color fundus photographs, 2260 
blood–retinal barrier permeability, retinal thickness, retinal vessel diameter and progression of diabetic macular edema, 3983 
corneal epithelial changes in diabetic Goto-Kakizaki rat, 590 
effect of VEGF-A on expression of profibrotic growth factor and ECM genes in retina (rat), 4267 
impaired apparent ion demand in experimental diabetic retinopathy (rat), 4753 
inducible NOS in diabetic retinopathy (mouse), 5257 
inhibition of diabetic leukostasis and blood–retinal barrier breakdown (mouse), 858 
loss of insulin-mediated vasoprotection (rat), 2350 
memantine effects in diabetic retinopathy (rat), 5152 
mitochondrial oxidative damage and diabetic retinopathy (mouse), 3805 
multifocal ERG implicit time delays and adaptation in, 5250 
OCT vs. stereoscopic fundus photography or biomicroscopy for diagnosing diabetic macular edema, 4963 
posture and diurnal variation in diabetic macular edema, 3318 
two spontaneous human Müller cell lines from diabetic donors, 874 
valsartan amelioration of retinal dysfunction in diabetic rats, 927 
vascular reactivity in diabetic retinopathy, 1744 
Diagnosis 
diagnostic accuracy of confocal scanning laser ophthalmoscopy in glaucoma, 214 
effect of atypical birefringence patterns on glaucoma detection using SLP with variable corneal compensation, 223 
OCT vs. stereoscopic fundus photography or biomicroscopy for diagnosing diabetic macular edema, 4963 
rule extraction for detection with OCT, 244 
validity and repeatability of new test for aniseikonia, 58 
Diclofenac, topical, effect on choroidal blood flow in postoperative pseudophakias, 5647 
Diet 
macular pigment and lutein supplementation in ABCA4 disease, 1319 
macular pigment optical density and carotenoids in, 571 
omega 3 fatty acids and IOP with age (rat), 756 
retina in vitamin E–deficient αTTP null mice, 396 
Dimethyl sulfoxide (DMSO), lens epithelial cell response to quercetin and, 3714 
Diving, decompression-induced ocular tear film bubbles, 3756 
DNA, bacterial DNA confers neuroprotection after optic nerve injury (mouse and rat), 3441 
DNase IIβ in mouse lens, 5638 
Docosahexaenoic acid (DHA), effect on retinal endothelial caveolae, 18 
Down syndrome, optical factors and resolution acuity in children with, 3995 
Drexler, Wolfgang, 2007 recipient of Cogan Award, 5339 
Driving 
importance and difficulty of driving in low-vision population, 4955 
risk of falls and motor vehicle collisions in glaucoma, 1149 
visual impairment and motor vehicle collisions among older drivers, 1483 
Drug adverse effects 
interferon effect on retinal microcirculation, 368 
retinal toxicity of intravitreal triamcinolone acetonide (rabbit), 390 
Drug delivery 
coated microneedles for, 4038 
intraocular nanoparticle, 5243 
pharmacokinetics of periocular injections, 2230 
to posterior segment, MRI assessment of (rabbit), 808 
testing of intraocular drugs for clinical use (new developments), 4861 
topotecan vitreous levels after periocular or intravenous delivery for retinoblastoma (rabbit), 3761 
Drusen, heredity of small hard drusen in twins aged 20–46 years, 833 
Dry eye 
blink-suppressed, oxidative stress and dry eye (rat), 1552 
controlled adverse environment and, 4026 
corneal innervation and sensitivity in patients with, 173 
evaluation of novel model (rabbit), 4468 
expression of Th-1 chemokines and receptors in mouse model of, 2561 
IFN-γ modulation of dry eye–induced conjunctival epithelial squamous metaplasia (mouse), 2553 
in vivo confocal study of cornea in Sjögren’s syndrome, 2017 
protective effects of uridine on cornea in rabbit model, 1102 
surface bacterial flora in normal and dry eyes, 5616 
Duane-radial ray syndrome, MRI in, 5505 
Duane’s retraction syndrome 
linkage analysis in, 189 
MRI evidence of orbital dysinnervation in, 194 
Dynamin-1, interaction with Tubby-like protein 1 (mouse), 2837 
E
Early-onset severe retinal dystrophy, Apex microarray genotyping of patients with Leber congenital amaurosis and, 5684 
Eicosapentaenoic acid (EPA) prevents choroidal neovascularization in mice, 4328 
Elastin maturation, in optic nerve head and astrocytes, population differences in, 3209 
Electrical stimulation 
bidirectional modulation of primary visual cortex excitability, 5782 
transcorneal 
effect in acute-phase optic nerve injury (rat), 2356 
protection of photoreceptors by (rat), 4725 
Electromyography, blink recovery in Bell’s palsy, 203 
Electronic medical records system for clinical research and the EMR–EDC interface (new developments), 4383 
Electroretinography (ERG) 
in CNGB3 achromatopsia, 3864 
CNTF-induced cellular changes in murine RP, 1389 
in dominant optic atrophy with OPA1 mutations, 820 
effect of spectral characteristics of Ganzfeld stimuli on photopic negative response (monkey), 4818 
ERG photostress test in evaluation of retinal function in ARM, 2806 
focal macular ERG and angiographic findings after PDT, 2254 
intramembrane determinant of peripherin/rds function for photoreceptor disk morphogenesis (mouse), 2975 
memantine effects in diabetic retinopathy (rat), 5152 
multifocal 
of central retinal function in advanced RP, 1312 
effect of acute hypoxia and hyperoxia on, 3405 
fellow eye losses in asymmetric glaucoma, 2626 
implicit time delays and adaptation in diabetic patients, 5250 
patterns of cone degeneration in RP, 383 
neurotrophic factors minimize renal toxicity of verteporfin PDT (rat), 430 
ocular hypopigmentation in Rab38cht/cht mice, 3905 
oscillatory potentials of dark-adapted ERG in ROP (rat), 5788 
pathological and electrophysiological features of canine cone–rod dystrophy, 4240 
pattern ERG monitoring of RGC dysfunction in murine glaucoma, 745 
phenotype of retinal degeneration in persons with RDH12 mutations, 1824 
preclinical safety evaluation of intravitreal VEGF antibody injection (rabbit), 1773 
preservation of macular oscillatory potentials in RP, 3312 
protective effect of TEMPOL derivatives against light-induced retinal damage (rat), 1900 
pseudoxanthoma elasticum with generalized retinal dysfunction, 4250 
restoration of visual responses in aged dystrophic rats after channelopsin-2 gene transfer, 3821 
retinal toxicity of intravitreal triamcinolone acetonide (rabbit), 390 
sensitivity to light-induced damage in autosomal dominant retinal disease (mouse), 1942 (erratum, 3436) 
SIRT1 neuroprotection in experimental optic neuritis (mouse), 3602 
tolerance to retinal ischemia by hypoxic preconditioning (mouse), 1735 
truncated rhodopsin in rod function and degeneration (moue), 2868 
EMD478761 implant, angiogenesis inhibition by, 5184 
Emmetropia, blur adaptation in myopia and, 2932 
Emmetropization 
form-deprivation myopia and effects of foveal ablation on (monkey), 3914 
temporal constraints in infant monkeys, 957 
Emodin, suppression of ocular surface inflammatory reaction, 5013 
Endocannabinoids, in retinal damage after high IOP-induced ischemia in rats, 2997 
Endoplasmic reticulum (ER) stress 
activation in degenerating photoreceptors (mouse), 5191 
double-stranded RNA-dependent protein kinase in retinal neuron damage induced by, 3729 
Endostatin, generation by limbal epithelial cells on amniotic membrane, 644 
Endothelial cells 
corneal 
adenosine and intercellular calcium wave in, 1518 
cultivated corneal endothelial cell sheet transplantation (monkey), 4519 
cultured, cryopreservation and genetic modification of, 3056 
isolation, preservation, and expansion of, 614 
reproducibility of endothelial assessment, 2062 
thrombin inhibition of intercellular Ca2+ wave propagation in, 120 
two semiautomated methods for evaluating endothelial cells of eye bank corneas, 3077 
DHA effect on retinal endothelial caveolae, 18 
donor-matched, gene expression profiles of, 2676 
novel alternatively spliced isoforms of RTEF-1 in, 3775 
retinal, hyperglycemia regulation of IGF-1 signaling in, 3878 
triamcinolone acetonide effects on leukocyte–endothelium interactions in ischemic retina (rat), 2831 
Endothelin-1–mediated signaling in expression of MMPs and TIMPs in astrocytes, 3737 
Endotoxin, visual system vulnerability to prenatal exposure to (sheep), 472 
Environmental conditions, dry eye and, 4026 
EphB2 and ephrin-B2 upregulation at optic nerve head in glaucomatous mice with axon loss, 5567 
Epidemiology 
astigmatism in 12-year-old Australian children, 73 
Blue Mountains Eye Study 
Chlamydia pneumoniae infection and AMD, 4007 
Inflammatory markers and hemostatic factors in ARM, 1983 
British Infantile and Childhood Glaucoma Eye Study, 4100 
CFH gene variants, smoking, and AMD risk in Japanese population, 5315 
ethnic differences in impact of parental myopia, 2520 
ethnic differences in macular pigment density and distribution, 3783 
hyperhomocysteinemia and low methionine stress as risk factors for central retinal venous occlusion, 1441 
IL-1 gene cluster polymorphisms and glaucoma in Chinese subjects, 2123 
INDEYE Feasibility Study 
prevalence of early and late AMD in rural Northern India, 1007 
prevalence of lens opacities in North India, 88 
Los Angeles Latino Eye Study, retinopathy in persons without diabetes, 4019 
macular pigment optical density in the elderly, 1458 
ocular dominance, laterality, and refraction in Singaporean children, 3533 
parental ocular and activity history and future myopia, 3524 
population study of X-linked RP, 4012 
Projeto Glaucoma, glaucoma prevalence in South Brazilian population, 4974 
Salisbury Eye Evaluation 
visual field loss and risk of falls in older adults, 4445 
visual impairment and motor vehicle crashes among older drivers, 1483 
Shihpai Eye Study, correctable visual impairment in elderly Taiwanese, 1032 
Epidermal growth factor receptor (EGFR) 
and c-Met in RPE wound healing, 2242 
and lysophosphatidic acid in corneal wound healing, 636 
Epithelium 
ciliary, fluid transport across, 321 
comparison of gene expression in human conjunctiva and cornea, 2050 
corneal 
antiapoptotic effects of thymosin β-4 on, 27 
apoptotic response of HSV-1 in, 789 (erratum, 1000) 
benzalkonium chloride–induced dephosphorylation of myosin light chain in, 2001 
CX3CR1 mediates homing of MHC class II–positive cells to (mouse), 1568 
in diabetic Goto-Kakizaki rat, 590 
expression of Th-1 chemokines and receptors in mouse model of dry eye, 2561 
flagellin pretreatment modulates immune response to Pseudomonas infection, 4664 
functions of MUC16 in, 4509 
HSV-1–dependent apoptosis in, 4980 
inhibition of TGF-β2 production by extracellular matrix, 1061 
notch signaling in differentiation and proliferation of, 3576 
PAF and repressor effect of Sp1 in expression of MMP-9 in, 1931 
PHSRN peptide stimulation of epithelial cell migration, 1110 
protective effect of caffeine against UV-induced apoptosis in, 652 
lens 
connexins and lens epithelial cell proliferation (mouse), 5630 
glucocorticoid receptor activation and signal transduction pathways in, 1724 
in vitro generation of functional lens-like structures, 1245 
response to quercetin and DMSO, 3714 
TGF-β1 repression of E-cadherin via Slug expression in, 2708 
thyroxine-ameliorated oxidative stress in, 3698 
transcytotic passage of albumin through, 1237 
limbal 
fate of limbal epithelial progenitor cells during ex vivo expansion, 605 
hypoxia-enhanced expansion of, 3586 
stem cell phenotype, 144 
retinal pigment (RPE) 
analysis of cells exposed to REF-1/TFPI-2, 516 
Bcl-xL in survival of, 3846 
c-Met and EGFR in RPE wound healing, 2242 
caspase-8–mediated apoptosis in, 3341 
controlling RPE injury after experimental retinal detachment (mouse), 1348 
cytotoxicity of triamcinolone acetonide on, 2792 
effect of inflammatory cytokines on RPE proliferation/migration, 5722 
endogenous bone marrow–derived cells express RPE cell markers, 4321 
gene expression profiling of zebrafish embryonic RPE, 881 
glypican 4, bactericidal/permeability-increasing protein in, 5750 
homeostatic regulation of photoreceptor cell integrity (Proctor Lecture), 4866 
IGF in RPE cell tractional force generation, 1892 
in vivo imaging of RPE mosaic in diseased retina, 2297 
JAM-A in corneal endothelium and, 3928 
lipid peroxidation and RPE lysosomal dysfunction, 1342 
MMP-14 and TIMP-2 overexpression protects against oxidant injury in, 5662 
ornithine cytotoxicity in, 464 
positive feedback regulation between MMP-9 and VEGF in, 4360 
posterior pole injury and peripheral RPE proliferation (pig), 355 
protective effect of lipoic acid against acrolein toxicity in, 339 
rapid recruitment of TIP47 in (mouse), 2858 
RPE and CD4 T-cell interaction in T-cell anergy (mouse), 4654 
selective RPE targeting with laser scanner (rabbit), 1782 
somatic ablation of Lrat gene in mouse RPE, 5377 
spermine cytotoxicity in, 455 
thrombin-induced VEGF expression in, 2738 
TRPC channels mediate basal calcium entry in RPE cells, 5767 
vitreous modulation of gene expression in, 1853 
transplantable rabbit carrier-free epithelial sheets, 597 
Erg-1 (ZENK), relative axial myopia in Egr-1 knockout mice, 11 
Errata, 17, 485, 1000, 1917, 1951, 2083, 2966, 3436, 4900, 5359 
Erythropoietin, neuroprotective effect on RGCs in glaucoma mice, 1212 
Esotropia 
motion-detection asymmetries in esotropic and normal infants, 5523 
progression in infancy, 661 
Esthesiometry, noncontact, corneal innervation and sensitivity in patients with dry eye, 173 
Estrogen receptor α gene, polymorphisms associated with AMD, 1012 
Everolimus, modulation of cholesterol homeostasis by antiproliferative drugs in pterygium fibroblasts, 3450 
Exfoliation syndrome 
genome-wide scan of, 4136 
proteomic analysis of exfoliation deposits, 1447 
Experimental autoimmune uveitis (EAU) 
CD8 regulatory T cells in (mouse), 2178 
IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in (mouse), 4153 
role of apoptosis in resolution of (rat), 5091 
suppression by anti-LFA-1α Ab (mouse), 2667 
Extracellular matrix (ECM), 1061 
ECM gene alternative splicing by TM cells in response to mechanical stretching, 1164 
effect of VEGF-A on expression of profibrotic growth factor and ECM genes in retina (rat), 4267 
inhibition of corneal epithelial TGF-β2 production by, 1061 
laminin regulation of α6 integrin gene expression, 3490 
morphology of organized ECM deposition by human corneal fibroblasts, 4050 
regulation of corneal fibroblasts by ECM mechanical properties, 5030 
secretion of cornea-like tissue in vitro by stem cells, 5038 
Extraocular muscles (EOMs) 
density and distribution of neuromuscular junctions in normal and botulinum toxin–treated EOMs (rabbit and monkey), 3594 
fascicular specialization in human and monkey rectus muscles, 3089 
horizontal rectus muscle anatomy in strabismic monkeys, 2576 
layer-specific differences in M-bands of (rat), 1119 
MRI in Duane-radial ray syndrome, 5505 
oculomotor nerve in congenital fibrosis of EOMs and congenital oculomotor palsy, 1601 
sideslip of medial rectus muscle during vertical eye rotation, 4527 
Eye bank 
organ culture and Optisol-GS storage of cultured human limbal epithelial cells, 5484 
two semiautomated methods for evaluating endothelial cells of eye bank corneas, 3077 
Eye development and growth 
apolipoprotein A-I and E in developing mouse retina, 1815 
effects of foveal ablation on emmetropization and form-deprivation myopia (monkey), 3914 
effects of IVF on structural features of neonatal eyes, 5454 
expression profiling of retinoschisin-deficient retina in postnatal mouse development, 891 
gene expression profiling of zebrafish embryonic RPE, 881 
histogenesis of intravitreal membrane and secondary vitreous (mouse), 1923 
immaturities limiting infant binocular stereopsis, 1424 
keratan sulfate in developing avian cornea, 3083 
laminins essential for basement membrane integrity (zebrafish), 2483 
opsin expression during retinal development in salmonid fishes, 866 
Pax6 required for postnatal eye development (mouse), 3292 
postnatal corneal transparency, keratocyte cell cycle exit and expression of ALDH1A1 (rabbit), 6274061 
simultaneous defocus integration during refractive development (chick), 5352 
structural specializations emerging late in mouse lens fiber cell differentiation, 3269 
temporal constraints on experimental emmetropization in infant monkeys, 957 
Eye examinations, attitudes of African-Americans about, 1989 
Eye-hand coordination, prehension deficits in amblyopia, 1139 
Eye movements 
blink recovery in Bell’s palsy, 203 
changes in dynamic properties during vertical saccades in acute superior oblique palsy (monkey), 2612 
cross-axis, in primates with A pattern strabismus, 665 
horizontal saccade disconjugacy in strabismic monkeys, 3107 
infantile nystagmus adapts to visual demand, 2089 
Listing’s plane shift due to semicircular canal stimulation, 2076 
oculomotor control in premature children, 2595 
Eyelid 
blink recovery in Bell’s palsy, 203 
influence of eyelid morphology on corneal shape, 112 
F
Falls 
multifocal spectacles and tripping in the elderly, 1466 
risk in glaucoma, 1149 
visual field loss and risk of falls in older adults, 4445 
Familial exudative vitreoretinopathy, gene mutations in Japanese patients with Norrie disease and, 1276 
Fascin 2, association with photoreceptor inner segment actin, 1380 
Fatty acids 
in meibomian gland secretions, 34 
omega 3 fatty acids and IOP with age (rat), 756 
retina in vitamin E–deficient αTTP null mice, 396 
Ferritin chains, in fiber cell canine and human lenses, 3968 
Fibroblast growth factor (FGF) 
neuroprotection in juvenile rat model of light-induced retinopathy, 2311 
protective effect of basic FGF-impregnated nanoparticles in RCS rats, 3381 
Fibroblasts 
corneal 
localization of ZO-1 in nucleolus of, 2043 
mitomycin C upregulates chemokine expression in, 2009 
modulation of CD8+ cytotoxic T lymphocyte effector function by fibroblasts derived from immunoprivileged cornea (mouse), 2194 
morphology of organized ECM deposition by, 4050 
regulation by ECM mechanical properties, 5030 
pterygium, modulation of cholesterol homeostasis by antiproliferative drugs in, 3450 
subconjunctival, tissue transglutaminase expression in, 1952 
Tenon’s capsule 
IFN-α and IFN-γ sensitize fibroblasts to mitomycin-C, 3655 
Rho-kinase signaling in, 2152 
Fluid transport across porcine ciliary epithelium, 321 
Fluorescein angiography 
microperimetry in idiopathic macular telangiectasia, 3788 
quantitative analysis of choroidal neovascularization, 349 
Fluorophotometry, pharmacokinetics of periocular injections using, 2230 
Folate, proton-coupled electrogenic folate transporter in retina, 5299 
4–1BB gene and lacrimal gland inflammation (mouse), 4608 
FOXC1 gene, genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma with FOXC1 and PITX2 mutations, 228 
Fractalkine mediation of angiogenesis, 5290 
Frequency-doubling illusion under scotopic illumination and in peripheral vision, 3413 
Frequency doubling perimetry, quantifying adaptation and fatigue effects in, 943 
Friedenwald Lecture 
Ilene K. Gipson, 2007 recipient of Friedenwald Award, 4390 
ocular surface: challenge to enable and protect vision, 4391 
FSCN2 gene, 208delG mutation in Chinese individuals, 530 
Functional optical zone of cornea, 1053 
Fundus photography 
automated differentiation of drusen, exudates, and cotton-wool spots, 2260 
CNGB3 achromatopsia, 3864 
microperimetry in idiopathic macular telangiectasia, 3788 
OCT vs. stereoscopic fundus photography or biomicroscopy for diagnosing diabetic macular edema, 4963 
panretinal, high-resolution color photography of mouse fundus, 2769 
simultaneous fundus imaging and OCT in mouse retina, 1283 
G
Ganglion cells, retinal (RGCs) 
calpains in RGC death, 5420 
CaMKIIαB mediates survival response in, 3854 
chemotactic effect of CNTF on macrophages in RGC survival and axonal regeneration (rat), 4257 
differentiation of retinal stem cells transplanted into murine RP models, 446 
double-stranded RNA-dependent protein kinase in ER stress–induced retinal neuron damage, 3729 
IOP-dependent RCG dysfunction in glaucomatous DBA/2J mice, 4573 
mitochondrial fission in differentiated RGC-5 cells, 2145 
neuroprotective effect of erythropoietin on RGCs in glaucoma mice, 1212 
optineurin mutant induces death of, 1607 
oxidative stress in hydrostatic pressure–induced RGC damage, 4580 
pattern ERG monitoring of RGC dysfunction in murine glaucoma, 745 
plasminogen activators cause death of, 1884 
prevention of excitotoxicity in RGCs by (+)pentazocine, 4785 
progressive dysfunction in DBA/2J mouse model of glaucoma, 4564 
retinal phenotypes in mammalian ciliary body after injury of (mouse), 5266 
synaptic contact between melanopsin-containing RGCs and rod bipolar cells (rat), 3812 
transgenic analysis of rodent anterior ischemic optic neuropathy–induced RGC stress and loss (mouse), 2304 
Gas jets in pneumatic retinopexy (pig), 2734 
Gelatinous drop-like corneal dystrophy 
cell junction–related proteins in, 1095 
TACSTD2 mutations in, 4490 
Gender effects 
astigmatism in 12-year-old Australian children, 73 
on color vision defects in asymptomatic carriers of Leber’s hereditary optic neuropathy, 2362 
retinal vascular caliber and children’s ethnicity, gender, and birth parameters, 1018 
Gene mutations 
ABCA4 mutations in severe retinopathies in Spanish patients, 985 
absence of 4–1BB gene function and lacrimal gland inflammation (mouse), 4608 
Apex microarray genotyping of patients with Leber congenital amaurosis and early-onset severe retinal dystrophy, 5684 
bestrophin mutations in canine multifocal retinopathy, 1959 
CERKL mutation in autosomal recessive RD among Yemenite Jews, 5431 
CFH gene variants, smoking, and AMD risk in Japanese population, 5315 
chloride channel activity of bestrophin mutants causing macular degeneration, 4694 
γD-crystallin–associated protein aggregation and lens fiber cell denucleation (mouse), 3719 
disease course of patients with X-linked RP due to RPGR mutations, 1298 
ERG findings in dominant optic atrophy with OPA1 mutations, 820 
genetic heterogeneity in microcornea-cataract, 3937 
genetic mapping of myopia susceptibility loci, 4924 
genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma with FOXC1 and PITX2 mutations, 228 
genotype–phenotype analysis of Bietti’s crystalline dystrophy in patients with CYP4V2 mutations, 5212 
glaucoma-associated CYP1B1 mutations in POAG and PACG phenotypes, 5439 
GNPTAB deficiency (mouse), 5221 
homozygosity for novel ABCA4 founder splicing mutation associated with Stargardt-like disease, 4308 
homozygous CRYBB1 deletion in congenital cataract, 2208 
identifying novel mutations in Leber congenital amaurosis and juvenile RP, 5690 
inner retinal abnormalities in X-linked RP with RPGR mutations, 4759 
in Japanese patients with Norrie disease and familial exudative vitreoretinopathy, 1276 
late-onset cone degeneration induced by Rds mutation and gene rescue (mouse), 5397 
macular pigment and lutein supplementation in ABCA4 disease, 1319 
mutant ND4 induces optic neuropathy (mouse), 1 
mutation screening for Leber congenital amaurosis, 5653 
novel CACNA1F mutation causes Åland Island eye disease, 2498 
novel mutation in carbonic anhydrase IV gene that causes RP, 3459 
novel TULP1 mutation causing Leber congenital amaurosis or early onset RD, 5160 
nuclear and mitochondrial analysis of primary angle-closure glaucoma, 5591 
ocular hypopigmentation in Rab38cht/cht mice, 3905 
optic nerve head in Myocilin glaucoma, 238 
optineurin mutant induces death of RGCs, 1607 
phenotype of retinal degeneration in persons with RDH12 mutations, 1824 
population study of X-linked RP, 4012 
PRPF31 mutations in autosomal dominant RP, 1330 
RDH12 and RPE65 differ in disease expression, 332 
retinal alterations in zebrafish laminin mutants, 2887 
RNFL thinning in autosomal dominant optic atrophy with OPA1 mutations, 4079 
RS1 mutants associated with X-linked retinoschisis, 2491 
T1799A BRAF mutation in iris melanoma, 4897 
TACSTD2 mutations in gelatinous drop-like corneal dystrophy, 4490 
208delG mutation in FSCN2 in Chinese individuals, 530 
UBIAD1 mutations in Schnyder crystalline corneal dystrophy, 5007 
zebrafish cone photoreceptor–specific promoter and genetic rescue of achromatopsia, 522 
Gene therapy 
AAV-mediated expression targeting of rods and cones with human rhodopsin kinase promoter (mouse), 3954 
antioxidant gene therapy in optic neuritis (mouse), 5360 
late-onset cone degeneration induced by Rds mutation and gene rescue (mouse), 5397 
NGF gene therapy improves corneal allograft survival (rat), 1043 
retinoschisin gene therapy in Rs1h-KO mouse, 3837 
RS1 mutants associated with X-linked retinoschisis and, 2491 
Gene transfer 
restoration of visual responses in aged dystrophic rats after channelopsin-2 gene transfer, 3821 
with self-complementary adeno-associated virus vectors, 3324 
Genetics 
comparison of gene expression in human conjunctiva and cornea, 2050 
corneal virulence of Candida albicans strains deficient in Tup1-regulated genes (mouse), 2535 
cryopreservation and genetic modification of cultured corneal endothelial cells, 3056 
ECM gene alternative splicing by TM cells in response to mechanical stretching, 1164 
epigenetic inactivation of RASSF1a in uveal melanoma, 486 
estrogen receptor α gene polymorphisms associated with AMD, 1012 
expression profiling of retinoschisin-deficient retina in postnatal mouse development, 891 
familial aggregation of refractive error in Old Order Amish, 4002 
form-deprivation myopia in chick and retinal gene expression, 3430 
gene expression analysis of photoreceptor cell loss in Bbs4-knockout mice, 3329 
gene expression in experimental glaucoma and optic nerve transection (rat), 5539 
gene expression profiles of donor-matched vascular endothelial cells, 2676 
gene expression profiling of zebrafish embryonic RPE, 881 
genetic ablation of cone photoreceptors and retinal fold elimination in rd7 mouse, 2799 
genetic determinant of retinal degeneration on mouse chromosome 6, 405 
genetic variations among ocular isolates of Staphylococcus epidermidis, 3239 
genome-wide scan of exfoliation syndrome, 4136 
heredity of small hard drusen in twins aged 20–46 years, 833 
heritability of pathologic features in glaucoma, 3669 
heritable features of optic disc, 2469 
HSP-70/Hom gene polymorphisms and uveitis in patients with sarcoidosis, 3019 
IL-1 gene cluster polymorphisms and glaucoma in Chinese subjects, 2123 
inheritance of peripapillary atrophy, 2529 
interferon gamma receptor 1 polymorphisms and atopic cataracts, 583 
laminin regulation of α6 integrin gene expression, 3490 
of Leber’s congenital amaurosis, 4284 
linkage analysis in Duane’s retraction syndrome, 189 
linkage mapping of ovine microphthalmia to chromosome 23, 3506 
linkage replication of MYP12 locus in myopia, 4433 
LOC387715 polymorphism and AMD, 1128 
novel retinal and cone photoreceptor transcripts, 5388 
optic nerve head gene expression after exposure to elevated IOP in rat glaucoma model, 3161 
persistent hyperplastic primary vitreous due to somatic mosaic deletion of Arf (mouse), 491 
of pigment changes and geographic atrophy, 3005 
prognosis-determinant candidate genes in pterygia, 3566 
promoter methylation status of multiple genes in uveal melanoma, 4403 
roles of PAX6 and SOX2 in myopia, 4421 
and susceptibility to oxygen-induced retinopathy (rat), 1761 
targeted transgene expression in retinal Müller glia using lentiviral vectors, 1844 
transcriptome of Müller cells and two spontaneous cell lines, 5229 
vitreous modulation of gene expression in RPE cells, 1853 
Geographic atrophy, genetics of pigment changes and, 3005 
Geriatric population. See also Age effects 
attitudes of African-Americans about eye examinations, 1989 
CFH gene variants, smoking, and AMD risk in Japanese population, 5315 
circulating hematopoietic stem cells in neovascular AMD, 5464 
computer-based test for optimal visual acuity in AMD, 4838 
contrast sensitivity changes in glaucoma and normal aging, 2115 
LOC387715 polymorphism and AMD, 1128 
macular pigment optical density in, 1458 
macular temporal responsiveness in normal aging and ARM, 4811 
multifocal spectacles and tripping in, 1466 
retinal abnormalities in early Alzheimer’s disease, 2285 
retinal vascular network geometry and cognitive ability in, 1995 
Shihpai Eye Study, correctable visual impairment in elderly Taiwanese, 1032 
visual field loss and risk of falls in older adults, 4445 
visual impairment and motor vehicle crashes among older drivers, 1483 
visual spatial integration in, 2940 
Gipson, Ilene K., 2007 recipient of Friedenwald Award, 4390 
GJA8 gene, genetic heterogeneity in microcornea-cataract, 3937 
Glare, pupil size and retinal straylight, 2375 
Glaucoma 
advanced glycation end products in, 1201 
antiscarring effects of Y-27632 in glaucoma filtration surgery (rabbit), 5549 
APP and amyloid-β immunoreactivity in glaucomatous mouse retinas, 5085 
asymmetric, fellow eye losses in, 2626 
automated segmentation of optic disc from stereo color photographs, 1665 
British Infantile and Childhood Glaucoma Eye Study, 4100 
ceruloplasmin upregulation in (mouse), 727 
chondroitin sulfate-derived disaccharide protects retinal cells from elevated IOP (rat), 1181 
contrast sensitivity changes in normal aging and, 2115 
CYP1B1 mutations in POAG and PACG phenotypes, 5439 
decreasing visual field test–retest variability in, 1627 
detection of 
diagnostic accuracy of confocal scanning laser ophthalmoscopy, 214 
effect of atypical birefringence patterns on detection using SLP with variable corneal compensation, 223 
effect of disc size and disease severity on diagnostic accuracy of Heidelberg Retina Tomograph Glaucoma Probability Score, 2653 
imaging comparison of optic disc and RNFL in, 2644 
OCT and Heidelberg retinal tomography parameters in detecting early and moderate glaucoma, 3138 
rule extraction for detection with OCT, 244 
using scanning laser polarimetry with enhanced corneal compensation, 3146 
detection with dichoptic multifocal VEPs, 4590 
effect of 15-keto latanoprost on IOP and aqueous humor dynamics (monkey), 4143 
effects of IOP reduction on perimetric variability in, 4557 
effects of TGF-β2, BMP-4, and gremlin in TM, 1191 
elevated alkaline phosphatase in glaucomatous TM, 3184 
EphB2 and ephrin-B2 upregulation at optic nerve head in glaucomatous mice with axon loss, 5567 
experimental, Hsp27 phosphorylation in (rat), 4129 
gene expression in experimental glaucoma and optic nerve transection (rat), 5539 
genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma with FOXC1 and PITX2 mutations, 228 
heritability of pathologic features in, 3669 
and IL-1 gene cluster polymorphisms in Chinese subjects, 2123 
impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma, 5558 
in vitro studies of antiglaucomatous prostaglandin analogues, 4123 
IOP-dependent RCG dysfunction in glaucomatous DBA/2J mice, 4573 
mechanisms of immune system activation in, 705 
mental effort and independent mobility in, 3988 
multifocal VEP vs. standard automated perimetry in ocular hypertension and, 1173 
Myocilin, optic nerve head in, 238 
neuroprotective effect of erythropoietin on RGCs in mice, 1212 
normal-tension, circadian fluctuation of mean ocular perfusion pressure as risk factor for, 104 
novel spatial filter to monitor visual field progression in, 251 
nuclear and mitochondrial analysis of primary angle-closure glaucoma, 5591 
OCT and histology of RNFL thickness in (monkey), 3645 
optic nerve head gene expression after exposure to elevated IOP in rat, 3161 
oxidative stress in hydrostatic pressure–induced RGC damage, 4580 
pattern ERG monitoring of RGC dysfunction in (mouse), 745 
pharmacy claims data to study medication adherence in, 5052 
preperimetric, Stratus OCT in, 1635 
prevalence in South Brazilian population, 4974 
progressive RGC dysfunction in DBA/2J mouse model of, 4564 
relationship between visual field sensitivity and RNFL thickness measured by OCT, 258 
repeatability of confocal scanning laser ophthalmoscopy, SLP, and OCT in, 1156 
reproducibility of anterior chamber angle measurements by OCT, 3683 
retinotopic organization of primary visual cortex in, 733 
risk of falls and motor vehicle collisions in, 1149 
RNFL thickness after acute primary angle closure measured with OCT, 1659 
SLP and OCT in normal and glaucomatous eyes, 2099 
sodium 4-phenylbutyrate corrects myocilin misfolding in, 1683 
sources of motion-sensitivity loss in, 2913 
stronger structure–function relationship with enhanced corneal compensation than with variable corneal compensation in SLP, 1651 (erratum, 1917) 
structure vs. function in, 3662 
3-D histomorphometry of early glaucomatous monkey optic nerve head, 5068 
3-D histomorphometry of normal and early glaucomatous monkey optic nerve head, 3195, 4597 
visual field clustering with machine learning classifiers, 5582 
visual field progression determined by Monte Carlo simulation in, 1642 
Glaucoma Adherence and Persistency Study, pharmacy claims data to study glaucoma medication adherence, 5052 
Glial cell-derived neurotrophic factor (GDNF) 
Ret activation does not protect from light-induced damage (mouse), 5199 
stimulation of rods and dopaminergic amacrine cells (chick), 5306 
Glial cells 
contributions to retinal detachment–induced photoreceptor degeneration (mouse), 2760 
differentiation of retinal stem cells transplanted into murine RP models, 446 
retinal, intracellular events associated with ICG and BBG, 4426 
targeted transgene expression in retinal Müller glia using lentiviral vectors, 1844 
two spontaneous human Müller cell lines from diabetic donors, 874 
Glucocorticoid receptor, and signal transduction pathways in lens epithelial cells, 1724 
Glucose-6-phosphate dehydrogenase (G6PD), in retinal vein occlusion, 2747 
Glutamic acid, intramembrane determinant of peripherin/rds function for photoreceptor disk morphogenesis (mouse), 2975 
Glutathione, effect on binding of kynurenine to lens proteins, 3705 
Glycine uptake in lens core, role of GLYT2 in (rat), 5142 
Glycosaminoglycans 
choroidal regulation of scleral synthesis during recovery from induced myopia (chick), 2957 
keratan sulfate in developing avian cornea, 3083 
levels in tree shrew sclera during induced myopia development and recovery, 2947 
Glypican 4, bactericidal/permeability-increasing protein in RPE, 5750 
GNPTAB deficiency (mouse), 5221 
Goblet cells, conjunctival 
density after LASIK procedures, 2570 
neurotrophins in (rat), 1543 
Graft-versus-host disease (GVHD), chronic, HSP47 in lacrimal gland pathology in, 1079 
Granulocyte macrophage colony–stimulating factor (GM-CSF), expression in herpetic stromal keratitis, 277 
Gremelin, effects of TGF-β2, BMP-4, and gremlin in TM, 1191 
Gremlin and epithelial-to-mesenchymal transition in PVR, 4291 
Gyrate atrophy of choroid and retina 
ornithine cytotoxicity in RPE cells, 464 
spermine cytotoxicity in RPE cells, 455 
H
Hallucinations and visual loss in AMD, 1416 
Heat shock proteins (HSP) 
HSP-70/Hom gene polymorphisms and uveitis in patients with sarcoidosis, 3019 
Hsp27 phosphorylation in experimental glaucoma (rat), 4129 
HSP47 in lacrimal gland pathology in chronic GVHD, 1079 
Heavy-eye syndrome, strabismus with axial high myopia, 1132 
Heavy silicone oils, in vivo retinal tolerance in PVR (rabbit), 1873 
Heidelberg Retina Tomograph 
effect of disc size and disease severity on diagnostic accuracy of Glaucoma Probability Score, 2653 
and OCT parameters in detecting early and moderate glaucoma, 3138 
optic disc and nerve fiber layer in Singapore children, 4939 
of optic disc and RNFL in Singapore children, 4939 
Heme oxygenase-1, photoreceptor protection against light damage by overexpression of (rat), 5699 
Hemodynamics 
effect of topical diclofenac on choroidal blood flow in postoperative pseudophakias, 5647 
effects of pentoxifylline and alprostadil on, 815 
effects of topical clonidine vs. brimonidine on choroidal blood flow and IOP during squatting, 4220 
nitric oxide in choroidal blood flow regulation during light/dark transitions, 4215 
regulation of choroidal blood flow during changes in IOP, 3768 
vascular reactivity in diabetic retinopathy, 1744 
Hemostatic factors and inflammatory markers in ARM, 1983 
Hepatitis C virus infection, interferon effect on retinal microcirculation in, 368 
Hepatocyte growth factor (HGF), in retinal angiogenesis, 1793 
Herpes simplex virus (HSV) infection 
apoptotic response of HSV-1 in corneal epithelial cells, 789 (erratum, 1000) 
CXCR3 effects in HSV-infected mice, 4162 
θ-defensin in murine HSV-1 keratitis, 5118 
GM-CSF expression in herpetic stromal keratitis, 277 
HSV-1–dependent apoptosis in corneal epithelial cells (rabbit), 4980 
lipopeptide vaccines in prevention of, 4643 
macrophages as determinants of ocular HSV-1 infection in immunized mice, 5605 
modulation of CD8+ cytotoxic T lymphocyte effector function by fibroblasts derived from immunoprivileged cornea (mouse), 2194 
role of anti–glycoproteins D and K IgGs in herpes stromal keratitis, 2185 
15(S)-HETE–induced angiogenesis, role of MEK1 in, 4930 
High-pressure liquid chromatography (HPLC), measurement of ocular carotenoid levels, 543 
Histology 
adenovirus type 37 keratitis (mouse), 781 
axonal transport and cytoskeletal changes with elevated IOP (pig), 3632 
basal laminar deposit and membranous debris in early AMD, 968 
bestrophin mutations in canine multifocal retinopathy, 1959 
Candida virulence in keratomycosis (mouse), 774 
cell junction–related proteins in gelatinous drop-like corneal dystrophy, 1095 
cellular response to photoreceptor death in murine RD, 849 
fascicular specialization in human and monkey rectus muscles, 3089 
in GNPTAB deficiency (mouse), 5221 
horizontal rectus muscle anatomy in strabismic monkeys, 2576 
MMP enhancement of transscleral permeability, 752 
murine Ccl2/Cx3cr1 deficiency results in retinal lesions mimicking human AMD, 3827 
and OCT of RNFL thickness in glaucoma (monkey), 3645 
ocular hypopigmentation in Rab38cht/cht mice, 3905 
organ culture and Optisol-GS storage of cultured human limbal epithelial cells, 5484 
preclinical safety evaluation of intravitreal VEGF antibody injection (rabbit), 1773 
Pseudomonas keratitis in cathelicidin-deficient mice, 4498 
retinal alterations in zebrafish laminin mutants, 2887 
secreted aspartyl proteinases in Candida albicans keratitis (mouse), 3559 
Histone deacetylase and neuronal differentiation, 2845 
Hydrostatic pressure–induced RGC damage, oxidative stress in, 4580 
4-Hydroxy-2-nonenal, AMD and retinal protein modification by, 3469 
Hyperglycemia regulation of IGF-1 signaling in retinal endothelial cells, 3878 
Hyperhomocysteinemia and low methionine stress as risk factors for central retinal venous occlusion, 1441 
Hyperopia, familial aggregation of refractive error in Old Order Amish, 4002 
Hyperoxia 
effect in detached feline retina, 1335 
effect of acute hypoxia and hyperoxia on multifocal ERG, 3405 
retinal oxygen metabolism in retinal artery occlusion (rat), 2290 
Hypoxia 
effect of acute hypoxia and hyperoxia on multifocal ERG, 3405 
effect on limbal epithelial cells, 3586 
tolerance to retinal ischemia by hypoxic preconditioning (mouse), 1735 
I
Immune function 
bacterial transcytosis across conjunctival M cells (guinea pig), 2172 
CD8 regulatory T cells in experimental autoimmune uveitis (mouse), 2178 
CX3CR1 mediates homing of MHC class II–positive cells to mouse corneal epithelium, 1568 
IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in EAU (mouse), 4153 
Inflammatory markers and hemostatic factors in ARM, 1983 
lipopeptide vaccines to prevent ocular herpes infection, 4643 
mechanisms of immune system activation in glaucoma, 705 
modulation of CD8+ cytotoxic T lymphocyte effector function by fibroblasts derived from immunoprivileged cornea (mouse), 2194 
regulatory T cells enhance retinal graft survival (mouse), 5112 
role of ST2 in Pseudomonas keratitis (mouse), 4626 
RPE and CD4 T-cell interaction in T-cell anergy (mouse), 4654 
Immunocytochemistry 
angiotensin II and receptor subtypes in human retina, 3301 
effect of alkylphosphocholines on intraretinal proliferation in RD (rabbit), 1305 
gremlin and epithelial-to-mesenchymal transition in PVR, 4291 
loss of α3(IV) collagen in activated corneal keratocytes, 627 
muscarinic receptor subtypes on human cornea and conjunctiva, 2987 
novel retinal and cone photoreceptor transcripts, 5388 
OFF-type blue cone bipolar cell in rabbit retina, 3388 
opsin expression during retinal development in salmonid fishes, 866 
photoreceptor protective effect of minocycline, 412 
regional differences in cystine accumulation in rat lens, 1253 
role of GLYT2 in glycine uptake in lens core (rat), 5142 
thrombin-induced VEGF expression in RPE cells, 2738 
thrombin inhibition of intercellular Ca2+ wave propagation in corneal endothelial cells, 120 
transgenic corneal neurofluorescence in mice, 1535 
Immunoglobulin treatment of viral ocular infection (rabbit), 4171 
Immunohistochemistry 
advanced glycation end products in glaucoma, 1201 
allergic conjunctival inflammation and allogeneic response to donor cornea, 4044 
α1- and β1-adrenergic modulation of lacrimal gland function in mouse, 1504 
antiangiogenic effect of somatostatin receptor 2 (mouse), 3480 
APP and amyloid-β immunoreactivity in glaucomatous mouse retinas, 5085 
association of fascin 2 with photoreceptor inner segment actin, 1380 
axonal transport and cytoskeletal changes with elevated IOP (pig), 3632 
bacterial transcytosis across conjunctival M cells (guinea pig), 2172 
BMP-7 is antagonist of TGF-β2 in TM cells, 715 
bone marrow–derived cells in substantia propria of conjunctiva, 4476 
β-catenin and epithelial–mesenchymal transition in pathogenesis of pterygium, 1511 
cell junction–related proteins in gelatinous drop-like corneal dystrophy, 1095 
ceruloplasmin upregulation in glaucoma (mouse), 727 
changes in pericytes and smooth muscle cells in ROP (kitten), 1368 
characteristics of progenitor cells from ciliary body in mouse, rat, and human eyes, 1674 
CNTF-induced cellular changes in murine RP, 1389 
differential sensitivity of cones to iron-mediated oxidative damage (mouse), 438 
differentiation of retinal stem cells transplanted into murine RP models, 446 
effect of VEGF-A on expression of profibrotic growth factor and ECM genes in retina (rat), 4267 
GM-CSF expression in herpetic stromal keratitis, 277 
histogenesis of intravitreal membrane and secondary vitreous (mouse), 1923 
IFN-γ modulation of dry eye–induced conjunctival epithelial squamous metaplasia (mouse), 2553 
influence of thyroid hormone on lacrimal gland and ocular surface morphology (rat), 3038 
inhibition of diabetic leukostasis and blood–retinal barrier breakdown (mouse), 858 
intracellular phospholipases A2 in photoreceptor outer segment phagocytosis, 1401 
KIF14 expression and age at retinoblastoma diagnosis, 4901 
location of D-β-aspartic acid–containing proteins in human eyes, 3923 
macular and peripheral expression of bestrophin, 3372 
modeling behavior of uveal melanoma in mouse liver, 2967 
monosomy 3 and vasculogenic mimicry in uveal melanoma, 1918 
neuroprotection in juvenile rat model of light-induced retinopathy, 2311 
nonproteolytically activated prorenin in retinal neovascularization (mouse), 422 
pathological and electrophysiological features of canine cone–rod dystrophy, 4240 
phenotype of limbal epithelial stem cells, 144 
relative axial myopia in Egr-1 knockout mice, 11 
retinal alterations in zebrafish laminin mutants, 2887 
retinal cellular reorganization during normal aging, 2824 
RPE65 essential for cone function in NRL-deficient mice, 534 
substance P in pathogenesis of pterygia, 4482 
surfactant proteins A and D in human tear fluid and lacrimal system, 3945 
sutureless transplantation of amniotic membrane for ocular surface reconstruction, 1528 
synaptic contact between melanopsin-containing RGCs and rod bipolar cells (rat), 3812 
TNF-α–induced apoptosis in murine CMV retinitis, 1691 
tolerance to retinal ischemia by hypoxic preconditioning (mouse), 1735 
transplantable rabbit carrier-free epithelial sheets, 597 
truncated rhodopsin in rod function and degeneration (moue), 2868 
In vitro fertilization (IVF), effects on structural features of neonatal eyes, 5454 
INDEYE Feasibility Study 
prevalence of early and late AMD in rural Northern India, 1007 
prevalence of lens opacities in North India, 88 
Indocyanine green (ICG), intracellular events in retinal glial cells exposed to BBG and, 4426 
Indoleamine 2,3-dioxygenase (IDO), expression in human corneal cells, 4148 
Infantile esotropia 
motion-detection asymmetries in esotropic and normal infants, 5523 
progression of, 661 
Infantile nystagmus, adaptation to visual demand, 2089 
Infantile spasms, contrast sensitivity in children with, 3610 
Infection 
adenovirus type 37 keratitis (mouse), 781 
age-related differences in experimental S. aureus keratitis (rabbit), 5125 
apoptotic response of HSV-1 in corneal epithelial cells, 789 (erratum, 1000) 
bacterial infection and trachoma in The Gambia, 4440 
Blue Mountains Eye Study, Chlamydia pneumoniae infection and AMD, 4007 
Candida virulence in keratomycosis (mouse), 774 
cholesterol treatment for pneumococcal keratitis (rabbit), 2661 
corneal virulence of Candida albicans strains deficient in Tup1-regulated genes (mouse), 2535 
CXCR3 effects in HSV-infected mice, 4162 
θ-defensin in murine HSV-1 keratitis, 5118 
flagellin pretreatment modulates corneal epithelial immune response to Pseudomonas infection, 4664 
genetic variations among ocular isolates of Staphylococcus epidermidis, 3239 
GM-CSF expression in herpetic stromal keratitis, 277 
HSV-1–dependent apoptosis in corneal epithelial cells (rabbit), 4980 
iNOS and CMV spread in retina (mouse), 285 
interferon effect on retinal microcirculation in hepatitis C, 368 
macrophages as determinants of ocular HSV-1 infection in immunized mice, 5605 
mass treatment of trachoma and ocular Chlamydia trachomatis, 1492 
modulation of CD8+ cytotoxic T lymphocyte effector function by fibroblasts derived from immunoprivileged cornea (mouse), 2194 
oral immunization for Acanthamoeba keratitis (hamster), 5597 
phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops vs. 0.3% tobramycin eye drops for bacterial conjunctivitis, 3425 
Pseudomonas keratitis in cathelicidin-deficient mice, 4498 
regulation of IL-8 by S. aureus in conjunctival cells, 270 
role of anti–glycoproteins D and K IgGs in herpes stromal keratitis, 2185 
role of ST2 in Pseudomonas keratitis (mouse), 4626 
secreted aspartyl proteinases in Candida albicans keratitis (mouse), 3559 
spantide I in Pseudomonas aeruginosa keratitis (mouse), 797 
surface bacterial flora in normal and dry eyes, 5616 
TNF-α–induced apoptosis in murine CMV retinitis, 1691 
topical immunoglobulin treatment of adenoviral ocular infection (rabbit), 4171 
viral antigens in varicella zoster virus–induced uveitis, 3689 
visual system vulnerability to prenatal endotoxin exposure (sheep), 472 
Inflammation 
absence of 4–1BB gene function and lacrimal gland inflammation (mouse), 4608 
β-adrenergic receptors in inflammatory marker expression in Müller cells, 5276 
allergic conjunctival inflammation and allogeneic response to donor cornea, 4044 
angiotensin II type 1 receptor/NF-κB pathway in diabetes-induced retinal inflammation (mouse), 4342 
bevacizumab inhibition of inflammatory corneal angiogenesis and lymphangiogenesis (mouse), 2545 
complement factor H polymorphism, inflammatory mediators, and retinal vessel diameters, 3014 
effect of inflammatory cytokines on RPE proliferation/migration, 5722 
emodin suppression of ocular surface inflammatory reaction, 5013 
inflammatory markers and hemostatic factors in ARM, 1983 
Insulin-like growth factor (IGF) 
hyperglycemia regulation of IGF-1 signaling in retinal endothelial cells, 3878 
in RPE cell tractional force generation, 1892 
Insulin-mediated vasoprotection, loss of (rat), 2350 
Integrin, laminin regulation of α6 integrin gene expression, 3490 
Intelligent Distributed Ontology Consensus System, 2278 
Interferon (IFN) 
chemokine profile and autoimmune pathology in genetic IFN-γ deficiency (mouse), 4616 
effect on retinal microcirculation, 368 
IFN-α and IFN-γ sensitize Tenon fibroblasts to mitomycin-C, 3655 
IFN-γ modulation of dry eye–induced conjunctival epithelial squamous metaplasia (mouse), 2553 
interferon gamma receptor 1 polymorphisms and atopic cataracts, 583 
Interleukin-1 
gene cluster polymorphisms and glaucoma in Chinese subjects, 2123 
synergism of cytokine induction of MMP-3 in TM, 2634 
Interleukin-4 deficient MRL/MpJ mice, dacryoadenitis in, 5624 
Interleukin-8 
mitomycin C upregulates chemokine expression in corneal fibroblasts, 2009 
regulation by S. aureus in conjunctival cells, 270 
Interleukin-10, measurement in aqueous humor in screening for primary intraocular lymphoma, 3253 
Interleukin-17+ interphotoreceptor retinoid-binding protein-specific T cells in EAU (mouse), 4153 
Interocular brightness differences, visual adaptation to, 935 
Intraocular lens (IOL), novel in vitro model of posterior capsular opacity, 4679 
Intraocular pressure (IOP). See also Glaucoma 
axonal transport and cytoskeletal changes with elevated IOP (pig), 3632 
chondroitin sulfate-derived disaccharide protects retinal cells from elevated IOP (rat), 1181 
collagen cross-linking and IOP measurement, 5494 
corneal elasticity in damping of IOP, 2540 
effect of 15-keto latanoprost on IOP and aqueous humor dynamics (monkey), 4143 
effect of ocular hypertension on retinal nitridergic pathway activity (rat), 2127 
effects of IOP reduction on perimetric variability in glaucoma, 4557 
effects of topical clonidine vs. brimonidine on choroidal blood flow and IOP during squatting, 4220 
effects of topical Y-39983 on ocular tissues in rabbits and monkeys, 3216 
endocannabinoids in retinal damage after high IOP-induced ischemia in rats, 2997 
heritability of pathologic features in glaucoma, 3669 
at high altitude, 1622 
in vitro studies of antiglaucomatous prostaglandin analogues, 4123 
IOP-dependent RCG dysfunction in glaucomatous DBA/2J mice, 4573 
multifocal VEP vs. standard automated perimetry in glaucoma and ocular hypertension, 1173 
omega 3 fatty acids and IOP with age (rat), 756 
optic nerve head gene expression after exposure to elevated IOP in rat glaucoma model, 3161 
prostaglandin FP receptors and 24-hour IOP variation in mice, 2095 
real-time IOP during LASIK with mechanical microkeratome and femtosecond laser (pig), 68 
regulation of choroidal blood flow during changes in, 3768 
Intrinsic signal imaging, flash-induced light reflectance changes in macaque retina, 2903 
Iris melanoma, T1799A BRAF mutation in, 4897 
Iron 
differential sensitivity of cones to iron-mediated oxidative damage (mouse), 438 
ferritin H- and L-chains in fiber cell canine and human lenses, 3968 
Ischemia 
capillary degeneration in ischemia/reperfusion injury (rat), 361 
endocannabinoids in retinal damage after high IOP-induced ischemia in rats, 2997 
tolerance to retinal ischemia by hypoxic preconditioning (mouse), 1735 
triamcinolone acetonide effects on leukocyte–endothelium interactions in ischemic retina (rat), 2831 
J
Junctional adhesion molecules (JAMs), JAM-A in corneal endothelium and RPE, 3928 
K
Keratan sulfate, in developing avian cornea, 3083 
Keratitis 
Acanthamoeba, oral immunization for (hamster), 5597 
adenovirus type 37 (mouse), 781 
age-related differences in experimental S. aureus keratitis (rabbit), 5125 
Candida albicans, secreted aspartyl proteinases in (mouse), 3559 
Candida virulence in keratomycosis (mouse), 774 
θ-defensin in murine HSV-1 keratitis, 5118 
herpetic stromal, GM-CSF expression in, 277 
pneumococcal, cholesterol treatment for (rabbit), 2661 
Pseudomonas  
in cathelicidin-deficient mice, 4498 
role of ST2 in (mouse), 4626 
spantide I in (mouse), 797 
role of anti–glycoproteins D and K IgGs in herpes stromal keratitis, 2185 
Keratoconjunctivitis, vernal, trypsin inhibitory capacity in, 264 
Keratoconus 
biomechanical properties of cornea in, 3026 
magnitude and orientation of Zernike terms in, 3062 
OCT of birefringent properties of, 3551 
second-harmonic imaging microscopy in, 1087 
Keratocytes, corneal 
activated, loss of α3(IV) collagen in, 627 
CD18 integrins and neutrophil–keratocyte interactions during corneal wound healing (mouse), 5023 
postnatal corneal transparency, keratocyte cell cycle exit and expression of ALDH1A1 (rabbit), 6274061 
7-Ketocholesterol, caspase activation in retinal neurosensory cells by, 1362 
KIF14 expression and age at retinoblastoma diagnosis, 4901 
Kyurenine, reversible binding to lens proteins, 3705 
L
L-732,138, antitumor actions in retinoblastoma, 2775 
Lacerations, corneal, photo cross-linkable biodendrimers as ophthalmic adhesives, 2037 
Lacrimal system 
absence of 4–1BB gene function and lacrimal gland inflammation (mouse), 4608 
α1- and β1-adrenergic modulation of lacrimal gland function in mouse, 1504 
dacryoadenitis in IL-4 deficient MRL/MpJ mice, 5624 
HSP47 in lacrimal gland pathology in chronic GVHD, 1079 
influence of thyroid hormone on lacrimal gland and ocular surface morphology (rat), 3038 
regulation of acid/base transporters in lacrimal gland ductal epithelia (rabbit), 3746 
surfactant proteins A and D in human tear fluid and, 3945 
Laminin 
essential for basement membrane integrity (zebrafish), 2483 
regulation of α6 integrin gene expression, 3490 
retinal alterations in zebrafish laminin mutants, 2887 
Laser in situ keratomileusis (LASIK) 
goblet cell density after LASIK procedures, 2570 
predicting myopic regression after, 3516 
real-time IOP during LASIK with mechanical microkeratome and femtosecond laser (pig), 68 
Laser technology 
laser-activated solder for sealing corneal wounds, 1038 
selective RPE targeting with laser scanner (rabbit), 1782 
upregulation of VEGF after retinal scatter laser photocoagulation (mouse), 5677 
Latanoprost 
effect of 15-keto latanoprost on IOP and aqueous humor dynamics (monkey), 4143 
in vitro studies of antiglaucomatous prostaglandin analogues, 4123 
Leber congenital amaurosis 
Apex microarray genotyping of patients with early-onset severe retinal dystrophy and, 5684 
clinical and molecular genetics of, 4284 
identifying novel mutations in juvenile RP and, 5690 
mutation screening for, 5653 
novel TULP1 mutation causing early onset RD or, 5160 
RDH12 and RPE65 differ in disease expression, 332 
Leber hereditary optic neuropathy 
gender and color vision defects in asymptomatic carriers of, 2362 
mutant ND4 induces optic neuropathy in mouse, 1 
Lens intrinsic membrane protein-2 (Lim2), refractive defects and cataracts in mice lacking, 500 
Lens of eye 
calpain 3 and age-related cataracts (mouse), 2685 
connexins and epithelial cell proliferation (mouse), 5630 
γD-crystallin–associated protein aggregation and lens fiber cell denucleation (mouse), 3719 
degradation of C-terminal αA-crystallins in cataract, 4200 
DNase IIβ in mouse lens, 5638 
epithelial cell response to quercetin and DMSO, 3714 
ferritin H- and L-chains in fiber cell canine and human lenses, 3968 
genetic heterogeneity in microcornea-cataract, 3937 
glucocorticoid receptor activation and signal transduction pathways in lens epithelial cells, 1724 
homozygous CRYBB1 deletion in congenital cataract, 2208 
INDEYE Feasibility Study, prevalence of lens opacities in North India, 88 
in vitro generation of functional lens-like structures, 1245 
interferon gamma receptor 1 polymorphisms and atopic cataracts, 583 
lens cell survival in stressed capsular bag, 2701 
light scattering predicted from particles in nuclear cataracts using Mie scattering theory, 303 
MMP and TIMP expression in human lens cells, 4192 
optomechanical response of human and monkey lenses in a lens stretcher, 3260 
p53 expression and lens apoptosis after UV radiation exposure (rat), 4187 
phakosin motifs in lens fiber cell, 5132 
protein-bound UV filters in normal human lenses, 1718 
proteolytic mechanisms underlying mitochondrial degradation in (mouse), 293 
purinergic receptor–mediated regulation of lens connexin43, 4177 
refractive defects and cataracts in Lim2 null mice, 500 
regional differences in cystine accumulation in rat lens, 1253 
retinoic acids and cataractogenesis, 2224 
reversible binding of kynurenine to lens proteins, 3705 
role of GLYT2 in glycine uptake in lens core (rat), 5142 
spherical aberration changes after lens refilling with silicone oil (pig), 1261 
Src suppression blocks posterior capsule opacification (chick), 2214 
structural specializations emerging late in mouse lens fiber cell differentiation, 3269 
target protein sits in fenestrations of α-crystallin, 2695 
TGF-β1 repression of E-cadherin via Slug expression in, 2708 
thyroxine-ameliorated oxidative stress in lens epithelial cells, 3698 
transcytotic passage of albumin through lens epithelial cells, 1237 
Lentiviral vectors, targeted transgene expression in retinal Müller glia using, 1844 
Leukocyte function associated antigen (LFA), suppression of experimental autoimmune uveitis by anti-LFA-1α Ab (mouse), 2667 
Leukostasis, inducible NOS in diabetic retinopathy (mouse), 5257 
Light/dark transitions 
dynamic analysis of changes of anterior chamber angle with anterior segment OCT, 4116 
nitric oxide in choroidal blood flow regulation during, 4215 
Light exposure 
apoptosis induced by, 40 
complement factor D and photoreceptor susceptibility to light-induced damage (mouse), 5282 
cone loss with impaired choroidal circulation after (rat), 1864 
light threshold–controlled cone α−transducin translocation, 3350 
melanopsin-dependent persistence and photopotentiation of pupillary light responses (mouse), 1268 
neuroprotection in juvenile rat model of light-induced retinopathy, 2311 
photoreceptor degeneration, AP-1 activation and (dog), 4907 
photoreceptor protection against light damage by heme oxygenase-1 overexpression (rat), 5699 
protective effect of TEMPOL derivatives against light-induced retinal damage (rat), 1900 
sensitivity to light-induced damage in autosomal dominant retinal disease (mouse), 1942 (erratum, 3436) 
Light scattering 
objective measurement of backscattered light from cornea, 167 
predicted from particles in nuclear cataracts using Mie scattering theory, 303 
and ultrastructure of healed penetrating corneal wounds (rabbit), 157 
Limbal epithelial cells 
endostatin generation by cells cultivated on amniotic membrane, 644 
fate of limbal epithelial progenitor cells during ex vivo expansion, 605 
hypoxia-enhanced expansion of, 3586 
organ culture and Optisol-GS storage of cultured human limbal epithelial cells, 5484 
phenotype of limbal epithelial stem cells, 144 
Linkage analysis 
in Duane’s retraction syndrome, 189 
genome-wide scan of exfoliation syndrome, 4136 
linkage replication of MYP12 locus in myopia, 4433 
mapping of ovine microphthalmia to chromosome 23, 3506 
Lipid peroxidation and RPE lysosomal dysfunction, 1342 
Lipid rafts, DHA effect on retinal endothelial caveolae, 18 
Lipoic acid, protective effect against acrolein toxicity in RPE cells, 339 
Listing’s law, acute superior oblique palsy and (monkey), 2621 
Listing’s plane shift due to semicircular canal stimulation, 2076 
Liver 
modeling behavior of uveal melanoma in mouse liver, 2967 
molecular characteristics of liver metastases from uveal melanoma, 4890 
Liwan Eye Study, slit lamp–simulated oblique flashlight test in Chinese eyes, 5459 
LOC387715 polymorphism and AMD, 1128 
Los Angeles Latino Eye Study, retinopathy in persons without diabetes, 4019 
Low-vision rehabilitation and quality of life, 1476 
Lrat gene, somatic ablation in mouse RPE, 5377 
Lutein 
HDL transport into retina (chick), 4226 
HPLC measurement of ocular carotenoid levels, 543 
macular pigment and lutein supplementation in ABCA4 disease, 1319 
macular pigment optical density and carotenoids in diet and serum, 571 
and zeaxanthin protect photoreceptors from oxidative stress–induced apoptosis, 5168 
Lymphatic system 
bevacizumab inhibition of corneal angiogenesis and lymphangiogenesis (mouse), 2545 
LYVE-1–positive macrophages in murine eyes, 2162 
Lymphoma, primary intraocular 
IL-10 measurement in aqueous humor in screening for, 3253 
Th1/Th2 cytokine profile in (mouse), 3223 
Lysophosphatidic acid and EGFR signaling in corneal wound healing, 636 
LYVE-1–positive macrophages in murine eyes, 2162 
M
M cells, conjunctival, bacterial transcytosis across (guinea pig), 2172 
Macrophage migration inhibitory factor, role in neovascularization (mouse), 3545 
Macrophages 
chemotactic effect of CNTF on macrophages in RGC survival and axonal regeneration (rat), 4257 
as determinants of ocular HSV-1 infection in immunized mice, 5605 
in vivo retinal immunostaining demonstrates macrophage association with growing and regressing vessels, 4335 
LYVE-1–positive macrophages in murine eyes, 2162 
Macula 
ethnic differences in macular pigment density and distribution, 3783 
identification of 3-methoxyzeaxanthin in, 1435 
macular and peripheral expression of bestrophin, 3372 
macular pigment: test of acuity hypothesis, 2922 
macular pigment optical density and carotenoids in diet and serum, 571 
macular temporal responsiveness in normal aging and ARM, 4811 
macular thickness measurements in myopia, 376 
microperimetry in idiopathic macular telangiectasia, 3788 
OCT of macula in congenital achromatopsia, 2249 
OCT of macular structure in preterm and full-term children, 5207 
suprathreshold contrast matching in maculopathy, 3419 
Macular degeneration 
age-related (AMD) 
anxiety and depression in, 1498 
basal laminar deposit and membranous debris in early AMD, 968 
CFH gene variants, smoking, and AMD risk in Japanese population, 5315 
Chlamydia pneumoniae infection and, 4007 
circulating hematopoietic stem cells in neovascular AMD, 5464 
computer-based test for optimal visual acuity in, 4838 
dendritic and synaptic plasticity of neurons in, 2782 
estrogen receptor α gene polymorphisms associated with, 1012 
genetics of pigment changes and geographic atrophy, 3005 
haplotypes spanning complement factor H gene are protective against, 4277 
heredity of small hard drusen in twins aged 20–46 years, 833 
HPLC measurement of ocular carotenoid levels, 543 
Intelligent Distributed Ontology Consensus System, 2278 
LOC387715 polymorphism and, 1128 
murine Ccl2/Cx3cr1 deficiency results in retinal lesions mimicking, 3827 
prevalence of early and late AMD in rural Northern India, 1007 
pseudophakia and neovascular AMD, 1472 
public health impact of neovascular AMD treatments, 96 
reproducibility of quantitative OCT in, 4300 
and retinal protein modification by 4-hydroxy-2-nonenal, 3469 
scavenger receptors for oxidized lipoprotein in, 1801 
SOD2 knockdown mouse model of early AMD, 4407 
suppression of choroidal neovascularization by ACE inhibition (mouse), 2321 
synergies of VEGF inhibition and PDT in, 1767 
visual loss and visual hallucinations in, 1416 
chloride channel activity of bestrophin mutants causing, 4694 
Stargardt disease 
eccentric fixation assessed by Tübingen perimetry, 5815 
homozygosity for novel ABCA4 founder splicing mutation associated with, 4308 
macular pigment and lutein supplementation in ABCA4 disease, 1319 
Macular edema, diabetic 
blood–retinal barrier permeability, retinal thickness, retinal vessel diameter and progression of, 3983 
OCT vs. stereoscopic fundus photography or biomicroscopy for diagnosis of, 4963 
posture and diurnal variation in, 3318 
Macular expression profiling, novel retinal and cone photoreceptor transcripts, 5388 
Macular oscillatory potentials, preservation in RP, 3312 
Macular pigment and lutein supplementation in ABCA4 disease, 1319 
Maculopathy 
age-related (ARM) 
ERG photostress test in evaluation of retinal function in, 2806 
inflammatory markers and hemostatic factors in, 1983 
macular temporal responsiveness in normal aging and, 4811 
in vivo imaging of RPE mosaic in diseased retina, 2297 
Magnetic resonance imaging (MRI) 
assessment of drug delivery to posterior segment (rabbit), 808 
in Duane-radial ray syndrome, 5505 
evidence of orbital dysinnervation in Duane’s retraction syndrome, 194 
manganese-enhanced 
of choroidal melanoma xenografts (rat), 963 
in experimental ROP (rat), 4733 
impaired apparent ion demand in experimental diabetic retinopathy (rat), 4753 
of intraretinal ion demand in ocular injury (rat), 3796 
of oculomotor nerve in congenital fibrosis of EOMs and congenital oculomotor palsy, 1601 
residual visual function after loss of both cerebral hemispheres in infancy, 3098 
sideslip of medial rectus muscle during vertical eye rotation, 4527 
and sonography of retrobulbar human optic nerve, 1913 
strabismus with axial high myopia, 1132 
Manual dexterity and reading speed with hand-held magnifier, 4368 
Matrix metalloproteinases (MMPs) 
actin cytoskeletal integrity and MMP-2 activation in TM cells, 2105 
endostatin generation by MMP and cathepsin from limbal epithelial cells on amniotic membrane, 644 
Endothelin-1–mediated signaling in expression of MMPs and TIMPs in astrocytes, 3737 
enhanced transscleral permeability with, 752 
manipulation of MMPs to reduce retinal neovascularization in oxygen-induced retinopathy (rat), 907 
MMP-14 and TIMP-2 overexpression protects against oxidant injury in RPE, 5662 
MMP and TIMP expression in human lens cells, 4192 
PAF and repressor effect of Sp1 in expression of MMP-9 in corneal epithelial cells, 1931 
positive feedback regulation between MMP-9 and VEGF in RPE cells, 4360 
synergism of cytokine induction of MMP-3 in TM, 2634 
Mean ocular perfusion pressure, circadian fluctuations as risk factor for normal-tension glaucoma, 104 
Medications 
antiangiogenic effects of bisphosphonates (mouse), 5716 
atorvastatin inhibition of choroidal neovascularization (mouse), 1839 
bevacizumab inhibition of corneal angiogenesis and lymphangiogenesis (mouse), 2545 
bimatoprost, prostamide activity, and conventional drainage, 4107 
bortezomib-induced apoptosis in human retinoblastoma cell lines, 4706 
cannabinoid receptors and bimatoprost-induced contractions of ciliary muscle, 3677 
clearance of intravitreal voriconazole (rabbit), 2238 
coated microneedles for drug delivery, 4038 
cytotoxicity of triamcinolone acetonide on RPE cells, 2792 
effect of 15-keto latanoprost on IOP and aqueous humor dynamics (monkey), 4143 
effect of topical diclofenac on choroidal blood flow in postoperative pseudophakias, 5647 
effects of intravitreous bevacizumab on neovascularization (rabbit), 5708 
effects of pentoxifylline and alprostadil on ocular hemodynamics, 815 
effects of topical clonidine vs. brimonidine on choroidal blood flow and IOP during squatting, 4220 
episcleral cyclosporine implant for keratoplasty rejection, 2023 
in vitro studies of antiglaucomatous prostaglandin analogues, 4123 
interferon effect on retinal microcirculation, 368 
mitomycin C upregulates chemokine expression in corneal fibroblasts, 2009 
MRI assessment of drug delivery to posterior segment (rabbit), 808 
pharmacokinetics of periocular injections, 2230 
photoreceptor protective effect of minocycline, 412 
retinal penetration of bevacizumab after intravitreal injection (monkey), 2814 
retinal toxicity of intravitreal triamcinolone acetonide (rabbit), 390 
simvastatin-induced dilation of porcine retinal arterioles, 825 
slow-releasing tranilast in PTFE/PLGA after strabismus surgery (rabbit), 699 
suppression of choroidal neovascularization by ACE inhibition (mouse), 2321 
triamcinolone acetonide effects on leukocyte–endothelium interactions in ischemic retina (rat), 2831 
triamcinolone acetonide-mediated oxidative injury, compared with dexamethasone, 5742 
valsartan amelioration of retinal dysfunction in diabetic rats, 927 
Meibomian gland, fatty acids in secretions of, 34 
MEK1, role in 15(S)-HETE–induced angiogenesis, 4930 
Melanocortin 1 receptor, expression in uveal melanoma, 1219 
Melanoma, uveal 
APITD1 expression and, 4919 
BMP-7 inhibits growth of, 4882 
direct-infection model of early hepatic metastasis, 4399 
epigenetic inactivation of RASSF1a in, 486 
manganese-enhanced MRI of choroidal melanoma xenografts (rat), 963 
melanocortin 1 receptor expression in, 1219 
molecular characteristics of liver metastases from, 4890 
monosomy 3 and vasculogenic mimicry in, 1918 
promoter methylation status of multiple genes in, 4403 
T1799A BRAF mutation in iris melanoma, 4897 
Melanopsin-containing RGCs, synaptic contact between rod bipolar cells and (rat), 3812 
Melanopsin-dependent persistence and photopotentiation of pupillary responses (mouse), 1268 
Memantine, effects in diabetic retinopathy (rat), 5152 
Mental effort and independent mobility in glaucoma, 3988 
Methods 
Apex microarray genotyping of patients with Leber congenital amaurosis and early-onset severe retinal dystrophy, 5684 
assessment of central retinal function in advanced RP, 1312 
automated segmentation of optic disc from stereo color photographs, 1665 
computer-based test for optimal visual acuity in AMD, 4838 
decreasing visual field test–retest variability in glaucoma, 1627 
diagnostic accuracy of confocal scanning laser ophthalmoscopy in glaucoma, 214 
dynamic analysis of dark–light changes of anterior chamber angle with anterior segment OCT, 4116 
eccentric fixation in Stargardt’s disease assessed by Tübingen perimetry, 5815 
ERG photostress test in evaluation of retinal function in ARM, 2806 
evaluation of retinal status using chromatic pupil light reflex activity (dog), 5178 
glaucoma detection with dichoptic multifocal VEPs, 4590 
Heidelberg Retina Tomograph of optic disc and RNFL in Singapore children, 4939 
HPLC measurement of ocular carotenoid levels, 543 
imaging comparison of optic disc and RNFL in glaucoma detection, 2644 
intrinsic signal imaging in macaque retina, 2903 
light scattering predicted from particles in nuclear cataracts using Mie scattering theory, 303 
Liwan Eye Study, slit lamp–simulated oblique flashlight test in Chinese eyes, 5459 
measurement of ocular surface irritation with Ocular Comfort Index, 4451 
microperimetry in idiopathic macular telangiectasia, 3788 
multiplex bead analysis of vitreous humor, 2203 
new tools for evaluation of toxic ocular surface changes in rat, 5473 
nondestructive quantification of analyte diffusion using OCT (rabbit), 2726 
novel spatial filter to monitor glaucomatous visual field progression, 251 
OCT vs. stereoscopic fundus photography or biomicroscopy for diagnosing diabetic macular edema, 4963 
optic disc evaluation by OCT in nonarteritic anterior ischemic optic neuropathy, 4087 
optic disc measurements in myopia with OCT and confocal scanning laser ophthalmoscopy, 3178 
optical imaging of retina activated by suprachoroidal-transretinal stimulation (cat), 4777 
pachymetric mapping with Visante anterior segment-OCT, 5499 
panretinal, high-resolution color photography of mouse fundus, 2769 
pattern ERG monitoring of RGC dysfunction in murine glaucoma, 745 
predicting myopic regression after LASIK, 3516 
quantitative subanalysis of OCT data, 839 
rarebit perimetry, 5320 
relationship between visual field sensitivity and RNFL thickness measured by OCT, 258 
repeatability of confocal scanning laser ophthalmoscopy, SLP, and OCT in glaucoma, 1156 
repeatability of Humphrey perimetry in RP patients, 4720 
reproducibility of anterior chamber angle measurements by OCT, 3683 
reproducibility of endothelial assessment, 2062 
reproducibility of quantitative OCT in neovascular AMD, 4300 
screening and diagnosis of optic pathway gliomas in children using VEPs, 2895 
sensitivity of temporal artery biopsy, 675 
simultaneous fundus imaging and OCT in mouse retina, 1283 
SLP and OCT in normal and glaucomatous eyes, 2099 
spatial frequency selectivity of human motion system revealed by masking, 3897 
spatial luminance contrast sensitivity measured with transient VEP, 3396 
spectral-domain OCT for 3D retinal imaging of rodent retina, 1808 
topographic angiography in classic and occult choroidal neovascularization, 1751 
two semiautomated methods for evaluating endothelial cells of eye bank corneas, 3077 
validation study of VEP Vernier acuity in adults, 4070 
validity and repeatability of new test for aniseikonia, 58 
visual field clustering with machine learning classifiers, 5582 
3-Methoxyzeaxanthin in macula, 1435 
Micro RNA expression (miRNA) 
in human and rat retinas, 3962 
in mouse eye, 509 
Microarray analysis 
Apex microarray genotyping of patients with Leber congenital amaurosis and early-onset severe retinal dystrophy, 5684 
comparison of gene expression in human conjunctiva and cornea, 2050 
identifying novel mutations in Leber congenital amaurosis and juvenile RP, 5690 
molecular characteristics of liver metastases from uveal melanoma, 4890 
novel retinal and cone photoreceptor transcripts, 5388 
of RPE cells exposed to REF-1/TFPI-2, 516 
vitreous modulation of gene expression in RPE cells, 1853 
Microperimetry in idiopathic macular telangiectasia, 3788 
Microphthalmia, linkage mapping to chromosome 23 (sheep), 3506 
Mie scattering theory, light scattering predicted from particles in nuclear cataracts using, 303 
Minocycline, photoreceptor protective effect of, 412 
Mitochondria 
mitochondrial fission in differentiated RGC-5 cells, 2145 
nuclear and mitochondrial analysis of primary angle-closure glaucoma, 5591 
oxidative damage and diabetic retinopathy (mouse), 3805 
protective effect of lipoic acid against acrolein-induced toxicity and mitochondrial dysfunction in RPE cells, 339 
proteolytic mechanisms underlying degradation in lens (mouse), 293 
suppression of mitochondrial oxidative stress in optic neuritis (mouse), 681 
Mitogen-activated protein kinases (MAPKs), and NF-κB in photoreceptor apoptosis, 4766 
Mitomycin-C 
IFN-α and IFN-γ sensitize Tenon fibroblasts to, 3655 
upregulation of chemokine expression in corneal fibroblasts, 2009 
Mitosis defect, induced by Pax6 p46 overexpression, 5408 
Monocyte chemoattractant protein-1, mitomycin C upregulates chemokine expression in corneal fibroblasts, 2009 
Monosomy 3 and vasculogenic mimicry in uveal melanoma, 1918 
Monte Carlo simulation of visual field progression in glaucoma, 1642 
Motion-sensitivity loss in glaucoma, 2913 
Motor vehicle collisions 
among older drivers, visual impairment and, 1483 
risk in glaucoma, 1149 
Mucins 
functions of MUC16 in corneal epithelial cells, 4509 
ocular surface: challenge to enable and protect vision (Friedenwald Lecture), 4391 
Müller cells 
β-adrenergic receptors in inflammatory marker expression in, 5276 
targeted transgene expression in retinal Müller glia using lentiviral vectors, 1844 
transcriptome of Müller cells and two spontaneous cell lines, 5229 
two spontaneous human Müller cell lines from diabetic donors, 874 
Multifocal spectacles and tripping in the elderly, 1466 
Multiple sclerosis 
heterogeneity of lesions in optic neuritis, 4549 
OCT in, 5773 
visual field and RNFL measurements in, 5798 
Multiplex bead analysis of vitreous humor, 2203 
Muscarinic receptor subtypes on human cornea and conjunctiva, 2987 
Myasthenia gravis, autoimmune ocular, new mouse model, 5101 
Myocilin glaucoma 
optic nerve head in, 238 
sodium 4-phenylbutyrate corrects myocilin misfolding, 1683 
Myofibroblasts, corneal, TLR-3 and -9 in, 3069 
Myopia 
axial length and peripheral refractive error before and after onset of, 2510 
blur adaptation in emmetropia and, 2932 
choroidal regulation of scleral glycosaminoglycan synthesis during recovery from induced myopia (chick), 2957 
contrast sensitivity and higher-order aberrations after orthokeratology for, 550 
dynamics of accommodative facility in myopes, 4375 
effect on contrast thresholds, 2371 
effects of foveal ablation on emmetropization and form-deprivation myopia (monkey), 3914 
ethnic differences in impact of parental myopia, 2520 
familial aggregation of refractive error in Old Order Amish, 4002 
form-deprivation myopia in chick and retinal gene expression, 3430 
genetic mapping of susceptibility loci for, 4924 
glycosaminoglycan levels in tree shrew sclera during induced myopia development and recovery, 2947 
linkage replication of MYP12 locus in, 4433 
macular thickness measurements in, 376 
myopia correction and self-reported visual functioning in Mexican children, 4949 
optic disc measurements in myopia with OCT and confocal scanning laser ophthalmoscopy, 3178 
parental, and myopia in COMET children, 562 
parental ocular and activity history and future development of, 3524 
predicting myopic regression after LASIK, 3516 
relative axial myopia in Egr-1 knockout mice, 11 
roles of PAX6 and SOX2 in, 4421 
susceptibility of eyes of lower vertebrate to visual environment (tilapia), 4829 
treatment of strabismus with axial high myopia, 1132 
Myosin light chain, benzalkonium chloride–induced dephosphorylation of, 2001 
MYP12 locus in myopia, 4433 
N
Neovascularization. See also Angiogenesis 
antiangiogenic effect of somatostatin receptor 2 (mouse), 3480 
bevacizumab inhibition of corneal angiogenesis and lymphangiogenesis (mouse), 2545 
choroidal 
antiangiogenic effects of bisphosphonates (mouse), 5716 
atorvastatin inhibition of (mouse), 1839 
PDT and apoptosis in rat model, 4741 
quantitative fluorescein angiographic analysis of, 349 
reduced photoreceptor damage after PDT through NOS blockade (monkey), 2268 
suppression by ACE inhibition (mouse), 2321 
suppression by dendritic cell vaccination targeting VEGFR2 (mouse), 4795 
topographic angiography in classic and occult types, 1751 
effects of intravitreous bevacizumab on (rabbit), 5708 
endogenous TNFα suppression of neovascularization in corneal stroma (mouse), 3051 
EPA prevents choroidal neovascularization in mice, 4328 
in vivo retinal immunostaining demonstrates macrophage association with growing and regressing vessels, 4335 
pseudophakia and neovascular AMD, 1472 
public health impact of neovascular AMD treatments, 96 
RAGE ligand upregulation of VEGF secretion in ARPE-19 cells, 1355 
retinal 
inhibition by calcitriol (mouse), 2327 
manipulation of MMPs for reduction of, in oxygen-induced retinopathy (rat), 907 
nonproteolytically activated prorenin in (mouse), 422 
role of macrophage migration inhibitory factor in (mouse), 3545 
suppression by EMD478761 implant, 5184 
Nepafenac, corneal analgesic effects of, 182 
Nerve growth factor (NGF) gene therapy improves corneal allograft survival (rat), 1043 
Nerves and innervation. See also Retinal nerve fiber layer 
activation of BMP canonical signaling pathway in optic nerve head, 5058 
age-related decline in parasympathetic nerve fibers in submacular choroid, 479 
antioxidant gene therapy in optic neuritis (mouse), 5360 
axonal transport and cytoskeletal changes with elevated IOP (pig), 3632 
bacterial DNA confers neuroprotection after optic nerve injury (mouse and rat), 3441 
corneal innervation and cellular changes after corneal transplantation, 621 
corneal innervation and sensitivity in patients with dry eye, 173 
effect of transcorneal electrical stimulation in acute-phase optic nerve injury (rat), 2356 
effects of nepafenac on corneal sensory nerve fibers, 182 
EphB2 and ephrin-B2 upregulation at optic nerve head in glaucomatous mice with axon loss, 5567 
ERG findings in dominant optic atrophy with OPA1 mutations, 820 
gender and color vision defects in asymptomatic carriers of Leber’s hereditary optic neuropathy, 2362 
gene expression in experimental glaucoma and optic nerve transection (rat), 5539 
heterogeneity of lesions in optic neuritis, 4549 
improved conduction velocity after optic neuritis, 692 
impulse activity in corneal sensory nerve fibers after PRK, 4032 
innervation of tissue-engineered corneal implants (pig), 3537 
MRI evidence of orbital dysinnervation in Duane’s retraction syndrome, 194 
MRI in Duane-radial ray syndrome, 5505 
mutant ND4-induced optic neuropathy (mouse), 1 
oculomotor nerve in congenital fibrosis of EOMs and congenital oculomotor palsy, 1601 
optic disc evaluation by OCT in nonarteritic anterior ischemic optic neuropathy, 4087 
optic nerve head gene expression after exposure to elevated IOP in rat glaucoma model, 3161 
optic nerve head in Myocilin glaucoma, 238 
population differences in elastin maturation in optic nerve head and astrocytes, 3209 
predictors of relative afferent pupillary defect in optic neuropathy, 3616 
prenatal endotoxin exposure and optic nerve myelination (sheep), 472 
RNFL thinning in autosomal dominant optic atrophy with OPA1 mutations, 4079 
SIRT1 neuroprotection in experimental optic neuritis (mouse), 3602 
sonography and MRI of retrobulbar human optic nerve, 1913 
suppression of mitochondrial oxidative stress in optic neuritis (mouse), 681 
3-D histomorphometry of early glaucomatous monkey optic nerve head, 5068 
3-D histomorphometry of normal and early glaucomatous monkey optic nerve head, 3195, 4597 
transgenic analysis of rodent anterior ischemic optic neuropathy–induced RGC stress and loss (mouse), 2304 
transgenic corneal neurofluorescence in mice, 1535 
Neural reprogramming in retinal degeneration (mouse), 3364 
Neurofibromatosis, screening and diagnosis of optic pathway gliomas in children with, 2895 
Neurokinin-1 receptor antagonist, antitumor actions in retinoblastoma, 2775 
Neuromuscular junctions, density and distribution in normal and botulinum toxin–treated EOMs (rabbit and monkey), 3594 
Neurons 
dendritic and synaptic plasticity of neurons in AMD, 2782 
histone deacetylase and neuronal differentiation, 2845 
retinal cellular reorganization during normal aging, 2824 
Neuroprotection. See also Protective effects 
bacterial DNA confers neuroprotection after optic nerve injury (mouse and rat), 3441 
BDNF in retinal protection against light damage–mediated stress (mouse), 2877 
effect of transcorneal electrical stimulation in acute-phase optic nerve injury (rat), 2356 
in juvenile rat model of light-induced retinopathy, 2311 
SIRT1 neuroprotection in experimental optic neuritis (mouse), 3602 
Neuroprotection D1, in homeostatic regulation of photoreceptor cell integrity (Proctor Lecture), 4866 
Neurotrophins 
BDNF in retinal protection against light damage–mediated stress (mouse), 2877 
cellular changes in murine RP induced by CNTF, 1389 
chemotactic effect of CNTF on macrophages in RGC survival and axonal regeneration (rat), 4257 
minimizing renal toxicity of verteporfin PDT (rat), 430 
neuroprotection in juvenile rat model of light-induced retinopathy, 2311 
in rat conjunctival goblet cells, 1543 
Ret activation does not protect from light-induced damage (mouse), 5199 
Neutrophils 
CD18 integrins and neutrophil–keratocyte interactions during corneal wound healing (mouse), 5023 
GM-CSF expression in herpetic stromal keratitis, 277 
New developments 
electronic medical records system for clinical research and the EMR–EDC interface, 4383 
testing of intraocular drugs for clinical use, 4861 
Nicotine, attenuation of endotoxin-induced uveitis (rat), 2719 
Nitric oxide 
in choroidal blood flow regulation during light/dark transitions, 4215 
resveratrol-induced dilation of porcine retinal arterioles, 4232 
Nitric oxide synthase (NOS) 
effect of ocular hypertension on retinal nitridergic pathway activity (rat), 2127 
inducible NOS in diabetic retinopathy (mouse), 5257 
iNOS and CMV spread in retina (mouse), 285 
reduced photoreceptor damage after PDT through NOS blockade (monkey), 2268 
Nonarteritic anterior ischemic optic neuropathy (NAION), optic disc evaluation by OCT in, 4087 
Nonsteroidal anti-inflammatory drugs 
corneal analgesic effects of nepafenac, 182 
effect of topical diclofenac on choroidal blood flow in postoperative pseudophakias, 5647 
Norrie disease, gene mutations in Japanese patients with familial exudative vitreoretinopathy and, 1276 
Notch signaling in corneal epithelial cell differentiation and proliferation, 3576 
Nuclear factor-κB (NF-κB) 
angiotensin II type 1 receptor/NF-κB pathway in diabetes-induced retinal inflammation (mouse), 4342 
and HSV-1–dependent apoptosis in corneal epithelial cells (rabbit), 4980 
lactate causes NF-κB activation and CD44 shedding in cultured TM cells, 1615 
and MAPKs in photoreceptor apoptosis, 4766 
Nystagmus 
infantile, acuity development in, 4093 
infantile nystagmus adapts to visual demand, 2089 
optokinetic, in severely visually impaired patients, 4542 
O
Ocular Comfort Index, measurement of ocular surface irritation with, 4451 
Ocular dominance, laterality, and refraction in Singaporean children, 3533 
Ocular hypertension. See also Glaucoma; Intraocular pressure 
effect on retinal nitridergic pathway activity (rat), 2127 
multifocal VEP vs. standard automated perimetry in glaucoma and, 1173 
Ocular Response Analyzer, biomechanical properties of cornea, 3026 
Ocular surface 
challenge to enable and protect vision (Friedenwald Lecture), 4391 
emodin suppression of inflammatory reaction of, 5013 
measurement of ocular surface irritation with Ocular Comfort Index, 4451 
new tools for evaluation of toxic ocular surface changes in rat, 5473 
surface bacterial flora in normal and dry eyes, 5616 
sutureless transplantation of amniotic membrane for reconstruction of, 1528 
Ocular torsion due to semicircular canal stimulation, 2076 
Oculomotor control in premature children, 2595 
Oculomotor nerve, in congenital fibrosis of EOMs and congenital oculomotor palsy, 1601 
OFF-type blue cone bipolar cell in rabbit retina, 3388 
Omega 3 fatty acids and IOP with age (rat), 756 
OPA1 gene 
ERG findings in dominant optic atrophy with mutations of, 820 
RNFL thinning in autosomal dominant optic atrophy with mutations of, 4079 
Opsin, expression during retinal development in salmonid fishes, 866 
Optic atrophy 
ERG findings in dominant optic atrophy with OPA1 mutations, 820 
RNFL thinning in autosomal dominant optic atrophy with OPA1 mutations, 4079 
Optic disc 
automated segmentation from stereo color photographs, 1665 
cortical organization and optic disc damage in glaucoma, 733 
effect of disc size and disease severity on diagnostic accuracy of Heidelberg Retina Tomograph Glaucoma Probability Score, 2653 
evaluation by OCT in nonarteritic anterior ischemic optic neuropathy, 4087 
Heidelberg Retina Tomograph of optic disc and RNFL in Singapore children, 4939 
heritability of pathologic features in glaucoma, 3669 
heritable features, 2469 
imaging comparison of optic disc and RNFL in glaucoma detection, 2644 
measurements in myopia with OCT and confocal scanning laser ophthalmoscopy, 3178 
relation of retinal vessel caliber to optic disc and cup diameters, 63 
relationship of retinal vascular caliber with optic disc diameter in children, 4945 
Optic flow deficits in amblyopia, second-order, 5532 
Optic nerve 
activation of BMP canonical signaling pathway in optic nerve head, 5058 
antioxidant gene therapy in optic neuritis (mouse), 5360 
bacterial DNA confers neuroprotection after optic nerve injury (mouse and rat), 3441 
connective tissue structure of tree shrew optic nerve, 2134 
effect of transcorneal electrical stimulation in acute-phase optic nerve injury (rat), 2356 
EphB2 and ephrin-B2 upregulation at optic nerve head in glaucomatous mice with axon loss, 5567 
gender and color vision defects in asymptomatic carriers of Leber’s hereditary optic neuropathy, 2362 
gene expression in experimental glaucoma and optic nerve transection (rat), 5539 
heterogeneity of lesions in optic neuritis, 4549 
improved conduction velocity after optic neuritis, 692 
MRI evidence of orbital dysinnervation in Duane’s retraction syndrome, 194 
mutant ND4-induced optic neuropathy in mouse, 1 
optic disc evaluation by OCT in nonarteritic anterior ischemic optic neuropathy, 4087 
optic nerve head gene expression after exposure to elevated IOP in rat glaucoma model, 3161 
optic nerve head in Myocilin glaucoma, 238 
population differences in elastin maturation in optic nerve head and astrocytes, 3209 
predictors of relative afferent pupillary defect in optic neuropathy, 3616 
prenatal endotoxin exposure and optic nerve myelination (sheep), 472 
SIRT1 neuroprotection in experimental optic neuritis (mouse), 3602 
sonography and MRI of retrobulbar human optic nerve, 1913 
suppression of mitochondrial oxidative stress in optic neuritis (mouse), 681 
3-D histomorphometry of normal and early glaucomatous monkey optic nerve head, 3195, 4597 
transgenic analysis of rodent anterior ischemic optic neuropathy–induced RGC stress and loss (mouse), 2304 
Optical coherence tomography (OCT) 
of birefringent properties of keratoconus corneas, 3551 
cellular and functional OCT of human retina (Cogan Lecture), 5340 
dynamic analysis of dark–light changes of anterior chamber angle with anterior segment OCT, 4116 
effect of blinking on tear dynamics, 3032 
and Heidelberg retinal tomography parameters in detecting early and moderate glaucoma, 3138 
and histology of RNFL thickness in glaucoma (monkey), 3645 
inner retinal abnormalities in X-linked RP with RPGR mutations, 4759 
of macula in congenital achromatopsia, 2249 
of macular structure in preterm and full-term children, 5207 
microperimetry in idiopathic macular telangiectasia, 3788 
in multiple sclerosis, 5773 
nondestructive quantification of analyte diffusion (rabbit), 2726 
optic disc evaluation by OCT in nonarteritic anterior ischemic optic neuropathy, 4087 
optic disc measurements in myopia with OCT and confocal scanning laser ophthalmoscopy, 3178 
pachymetric mapping with Visante anterior segment-OCT, 5499 
peripapillary nerve fiber layer thickness profile with, 3154 
quantitative subanalysis of OCT data, 839 
RDH12 and RPE65 differ in disease expression, 332 
relationship between RNFL and perimetry measurements (monkey), 763 
relationship between visual field sensitivity and RNFL thickness, 258 
repeatability in glaucoma, 1156 
reproducibility of anterior chamber angle measurements with, 3683 
reproducibility of quantitative OCT in neovascular AMD, 4300 
retinal abnormalities in early Alzheimer’s disease, 2285 
RNFL defects in RP patients, 4748 
RNFL thickness after acute primary angle closure measured with, 1659 
rule extraction for glaucoma detection with, 244 
simultaneous fundus imaging and OCT in mouse retina, 1283 
and SLP in normal and glaucomatous eyes, 2099 
spectral-domain OCT for 3D retinal imaging of rodent retina, 1808 
vs. stereoscopic fundus photography or biomicroscopy for diagnosing diabetic macular edema, 4963 
Stratus OCT in preperimetric glaucoma, 1635 
structure vs. function in glaucoma, 3662 
Optical imaging of retina activated by suprachoroidal-transretinal stimulation (cat), 4777 
Optineurin mutant induces death of RGCs, 1607 
Ornithine cytotoxicity in RPE cells, 464 
Orthokeratology, contrast sensitivity and higher-order aberrations after, 550 
Oscillatory potentials of dark-adapted ERG in ROP (rat), 5788 
Outflow, omega 3 fatty acids and IOP with age (rat), 756 
Oxidative stress 
AMD and retinal protein modification by 4-hydroxy-2-nonenal, 3469 
bilberry anthocyanins in defense against, 2343 
and blink-suppressed dry eye (rat), 1552 
cytotoxicity evaluation of different vegetable oil vectors, 5000 
differential sensitivity of cones to iron-mediated oxidative damage (mouse), 438 
in hydrostatic pressure–induced RGC damage, 4580 
lens epithelial cell response to quercetin and DMSO, 3714 
lutein and zeaxanthin protect photoreceptors from apoptosis induced by, 5168 
mechanisms of immune system activation in glaucoma, 705 
mitochondrial, suppression in optic neuritis (mouse), 681 
mitochondrial oxidative damage and diabetic retinopathy (mouse), 3805 
MMP-14 and TIMP-2 overexpression protects against oxidant injury in RPE, 5662 
photoreceptor protective effect of minocycline against, 412 
protective effect of lipoic acid against acrolein toxicity in RPE cells, 339 
retina in vitamin E–deficient αTTP null mice, 396 
SOD2 knockdown mouse model of early AMD, 4407 
thyroxine-ameliorated, in lens epithelial cells, 3698 
triamcinolone acetonide-mediated oxidative injury, compared with dexamethasone, 5742 
Oxidized lipoprotein in AMD, scavenger receptors for, 1801 
Oxygen 
effect of acute hypoxia and hyperoxia on multifocal ERG, 3405 
effect of hyperoxia in detached feline retina, 1335 
retinal oxygen metabolism in retinal artery occlusion (rat), 2290 
Oxygen-induced retinopathy 
aquaporin-1–independent microvessel proliferation in mouse model of, 4802 
genetics and susceptibility to (rat), 1761 
manipulation of MMPs to reduce retinal neovascularization in (rat), 907 
riluzole inhibits retinal hemorrhage in (rat), 5671 
P
P2X7 cell death receptor activation, cytotoxicity evaluation of different vegetable oil vectors, 5000 
p38 MAP kinase pathway and stromelysin regulation in trabecular meshwork cells, 3126 
p53 expression and lens apoptosis after UV radiation exposure (rat), 4187 
Pachymetric mapping with Visante anterior segment-OCT, 5499 
Paclitaxel, in murine retinoblastoma model, 3437 
Parental ocular and activity history and future myopia, 3524 
PAX6  
expression in pigeon retina, 2503 
Pax6 p46 overexpression induces mitosis defect, 5408 
required for postnatal eye development (mouse), 3292 
role in myopia, 4421 
Pediatric population 
acuity development in infantile nystagmus, 4093 
anterior capsular plaque in congenital cataract, 4209 
astigmatism in 12-year-old Australian children, 73 
axial length and peripheral refractive error before and after onset of myopia, 2510 
biometry of Caucasian and African-American cataractous pediatric eyes, 4671 
British Infantile and Childhood Glaucoma Eye Study, 4100 
children unable to perform screening tests in Vision in Preschoolers Study, 83 
composition of infant vs. adult human corneal basement membranes, 4989 
contrast sensitivity in children with infantile spasms, 3610 
contribution of oculometric parameters to refraction by age and ethnicity, 4846 
cost-effectiveness of cycloplegic agents in Nigerian children, 1025 
effects of IVF on structural features of neonatal eyes, 5454 
ethnic differences in impact of parental myopia, 2520 
Heidelberg Retina Tomograph of optic disc and RNFL in Singapore children, 4939 
identifying novel mutations in Leber congenital amaurosis and juvenile RP, 5690 
immaturities limiting infant binocular stereopsis, 1424 
infants’ accommodation responses to dynamic stimuli, 949 
KIF14 expression and age at retinoblastoma diagnosis, 4901 
modeling dose-response in children with amblyopia, 2589 
motion-detection asymmetries in esotropic and normal infants, 5523 
myopia correction and self-reported visual functioning in Mexican children, 4949 
OCT of macular structure in preterm and full-term children, 5207 
ocular dominance, laterality, and refraction in Singaporean children, 3533 
oculomotor control in premature children, 2595 
optical factors and resolution acuity in children with Down syndrome, 3995 
parental myopia and progression of myopia in COMET children, 562 
parental ocular and activity history and future myopia, 3524 
perceptual learning and recovery of visual acuity in juvenile amblyopia, 5046 
progression of esotropia in infancy, 661 
relationship of retinal vascular caliber with optic disc diameter in children, 4945 
residual visual function after loss of both cerebral hemispheres in infancy, 3098 
retinal vascular caliber and children’s ethnicity, gender, and birth parameters, 1018 
scotopic visual thresholds in ROP, 4854 
screening and diagnosis of optic pathway gliomas in, 2895 
screening and treating amblyopia, 2084 
strabismus detection in preschool vision screening, 3115 
Penetrating keratoplasty (corneal transplantation) 
corneal innervation and cellular changes after, 621 
episcleral cyclosporine implant for keratoplasty rejection, 2023 
photo cross-linkable biodendrimers as ophthalmic adhesives for, 2037 
(+)Pentazocine, prevention of excitotoxicity in RGCs by, 4785 
Pentoxifylline, effects on ocular hemodynamics, 815 
Perceptual learning and recovery of visual acuity in juvenile amblyopia, 5046 
Pericytes, and smooth muscle cells in ROP (kitten), 1368 
Perimetry 
of central retinal function in advanced RP, 1312 
eccentric fixation in Stargardt’s disease assessed by Tübingen perimetry, 5815 
effects of IOP reduction on perimetric variability in glaucoma, 4557 
frequency doubling, quantifying adaptation and fatigue effects in, 943 
microperimetry in idiopathic macular telangiectasia, 3788 
multifocal VEP vs. standard automated perimetry in ocular hypertension and glaucoma, 1173 
relationship between RNFL and measurements of (monkey), 763 
repeatability of Humphrey perimetry in RP patients, 4720 
structure vs. function in glaucoma, 3662 
visual field clustering with machine learning classifiers, 5582 
Peripapillary atrophy, inheritance of, 2529 
Peripherin/rds function, intramembrane determinant of (mouse), 2975 
Persistent hyperplastic primary vitreous, due to somatic mosaic deletion of Arf (mouse), 491 
Phakosin motifs in lens fiber cell, 5132 
Pharmacokinetics 
bimatoprost, prostamide activity, and conventional drainage, 4107 
episcleral cyclosporine implant for keratoplasty rejection, 2023 
of periocular injections, 2230 
Pharmacy claims data to study glaucoma medication adherence, 5052 
Phospholipases A2, intracellular, in photoreceptor outer segment phagocytosis, 1401 
Photo cross-linkable biodendrimers as ophthalmic adhesives, 2037 
Photodynamic therapy (PDT) 
and apoptosis in rat choroidal neovascularization model, 4741 
focal macular ERG and angiographic findings after, 2254 
neurotrophic factors minimize renal toxicity of verteporfin PDT (rat), 430 
reduced photoreceptor damage after PDT through NOS blockade (monkey), 2268 
synergies of VEGF inhibition and PDT in AMD, 1767 
Photoreceptors 
AAV-mediated expression targeting of rods and cones with human rhodopsin kinase promoter (mouse), 3954 
acetylcholinesterase in photoreceptor death after photic stress (rat), 1290 
association of fascin 2 with photoreceptor inner segment actin, 1380 
cellular response to photoreceptor death in murine RD, 849 
circadian control of tyrosine phosphorylation of cGMP-gated ion channels in (chick), 901 
in CNGB3 achromatopsia, 3864 
complement factor D and photoreceptor susceptibility to light-induced damage (mouse), 5282 
cone loss with impaired choroidal circulation after light exposure (rat), 1864 
differential sensitivity of cones to iron-mediated oxidative damage (mouse), 438 
endoplasmic reticulum stress activation in degenerating photoreceptors (mouse), 5191 
function of visual arrestins in rod photoreceptors (mouse), 1968 
GDNF stimulation of rods and dopaminergic amacrine cells (chick), 5306 
gene expression analysis of photoreceptor cell loss in Bbs4-knockout mice, 3329 
genetic ablation of cone photoreceptors and retinal fold elimination in rd7 mouse, 2799 
glial contributions to retinal detachment–induced photoreceptor degeneration (mouse), 2760 
homeostatic regulation of photoreceptor cell integrity (Proctor Lecture), 4866 
interaction between Tubby-like protein 1 and dynamin-1 (mouse), 2837 
intracellular phospholipases A2 in outer segment phagocytosis, 1401 
intramembrane determinant of peripherin/rds function for photoreceptor disk morphogenesis (mouse), 2975 
late-onset cone degeneration induced by Rds mutation and gene rescue (mouse), 5397 
light exposure, photoreceptor degeneration, and AP-1 activation (dog), 4907 
light-induced apoptosis, 40 
light threshold–controlled cone α−transducin translocation, 3350 
lutein and zeaxanthin protect photoreceptors from oxidative stress–induced apoptosis, 5168 
multifocal ERG patterns of cone degeneration in RP, 383 
NF-κB and MAPKs in photoreceptor apoptosis, 4766 
novel retinal and cone photoreceptor transcripts, 5388 
OFF-type blue cone bipolar cell in rabbit retina, 3388 
pathological and electrophysiological features of canine cone–rod dystrophy, 4240 
protection against light damage by heme oxygenase-1 overexpression (rat), 5699 
reduced photoreceptor damage after PDT through NOS blockade (monkey), 2268 
Ret activation does not protect from light-induced damage (mouse), 5199 
rod function predicts blood vessel abnormality in ROP (rat), 4351 
RPE65 essential for cone function in NRL-deficient mice, 534 
synaptic contact between melanopsin-containing RGCs and rod bipolar cells (rat), 3812 
transcorneal electrical stimulation protection of (rat), 4725 
truncated rhodopsin in rod function and degeneration (moue), 2868 
Wnt signaling during photoreceptor degeneration, 5733 
zebrafish cone photoreceptor–specific promoter and genetic rescue of achromatopsia, 522 
Photorefractive keratectomy (PRK) 
impulse activity in corneal sensory nerve fibers after, 4032 
optical zone decentration and aberrations after (cat), 5806 
PHSRN peptide, stimulation of epithelial cell migration by, 1110 
Pigmentation 
ethnic differences in macular pigment density and distribution, 3783 
genetics of pigment changes and geographic atrophy, 3005 
macular pigment: test of acuity hypothesis, 2922 
macular pigment optical density in the elderly, 1458 
ocular hypopigmentation in Rab38cht/cht mice, 3905 
Pilocarpine 
coated microneedles for drug delivery, 4038 
pharmacologically manipulated accommodative dynamics (monkey), 323 
Pioglitazone, modulation of cholesterol homeostasis by antiproliferative drugs in pterygium fibroblasts, 3450 
PITX2 gene, genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma with FOXC1 and PITX2 mutations, 228 
Plasminogen activators cause death of RGCs, 1884 
Platelet-activating factor (PAF), and repressor effect of Sp1 in expression of MMP-9 in corneal epithelial cells, 1931 
Platelet-derived growth factor (PDGF)-C, in PVR, 2335 
Plus disease, changes in pericytes and smooth muscle cells in ROP (kitten), 1368 
Pneumatic retinopexy, gas jets in (pig), 2734 
Pneumococcal keratitis, cholesterol treatment for (rabbit), 2661 
Polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA), slow-releasing tranilast in PTFE/PLGA after strabismus surgery (rabbit), 699 
Posterior capsular opacification 
blocked by Src suppression (chick), 2214 
lens cell survival in stressed capsular bag, 2701 
novel in vitro model of, 4679 
Posture and diurnal variation in diabetic macular edema, 3318 
Potassium ion channels, resveratrol-induced dilation of porcine retinal arterioles, 4232 
Prehension deficits in amblyopia, 1139 
Primary angle closure, OCT measurement of RNFL thickness after, 1659 
Proctor Lecture 
homeostatic regulation of photoreceptor cell integrity, 4866 
Nicolas G. Bazan, 2007 recipient of Proctor Medal, 4864 
Progenitor cells from ciliary body in mouse, rat, and human eyes, 1674 
Projeto Glaucoma, glaucoma prevalence in South Brazilian population, 4974 
Proliferative vitreoretinopathy (PVR) 
gremlin and epithelial-to-mesenchymal transition in, 4291 
PDGF-C in, 2335 
in vivo retinal tolerance of heavy silicone oils (rabbit), 1873 
Prostaglandin FP receptors and 24-hour IOP variation in mice, 2095 
Prostheses and implants 
functional assessment of subretinal prosthetic (rat), 916 
innervation of tissue-engineered corneal implants (pig), 3537 
Protective effects 
bacterial DNA confers neuroprotection after optic nerve injury (mouse and rat), 3441 
of basic FGF-impregnated nanoparticles in RCS rats, 3381 
of caffeine against UV-induced apoptosis in corneal epithelial cells, 652 
chemotactic effect of CNTF on macrophages in RGC survival and axonal regeneration (rat), 4257 
chondroitin sulfate-derived disaccharide protects retinal cells from elevated IOP (rat), 1181 
of erythropoietin on RGCs in glaucoma mice, 1212 
glutathione effect on binding of kynurenine to lens proteins, 3705 
haplotypes spanning complement factor H gene are protective against AMD, 4277 
impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma, 5558 
of lipoic acid against acrolein toxicity in RPE cells, 339 
lipopeptide vaccines to prevent ocular herpes infection, 4643 
lutein and zeaxanthin protect photoreceptors from oxidative stress–induced apoptosis, 5168 
of minocycline on photoreceptors, 412 
MMP-14 and TIMP-2 overexpression protects against oxidant injury in RPE, 5662 
neuroprotection in juvenile rat model of light-induced retinopathy, 2311 
photoreceptor protection against light damage by heme oxygenase-1 overexpression (rat), 5699 
prevention of excitotoxicity in RGCs by (+)pentazocine, 4785 
SIRT1 neuroprotection in experimental optic neuritis (mouse), 3602 
suppression of mitochondrial oxidative stress in optic neuritis (mouse), 681 
of TEMPOL derivatives against light-induced retinal damage (rat), 1900 
transcorneal electrical stimulation protection of photoreceptors (rat), 4725 
of uridine on cornea in rabbit dry eye model, 1102 
Protein-bound UV filters in normal human lenses, 1718 
Proteolytic mechanisms underlying mitochondrial degradation in lens (mouse), 293 
Proteomics 
AMD and retinal protein modification by 4-hydroxy-2-nonenal, 3469 
analysis of exfoliation deposits, 1447 
analysis of RPE cells exposed to REF-1/TFPI-2, 516 
location of D-β-aspartic acid–containing proteins in human eyes, 3923 
Prothrombin, corneal activation to form thrombin, 134 
Proton-coupled electrogenic folate transporter in retina, 5299 
PRPF31 mutations, in autosomal dominant RP, 1330 
Pseudoexfoliation syndrome/glaucoma, impaired cytoprotective mechanisms in eyes with, 5558 
Pseudomonas aeruginosa keratitis 
in cathelicidin-deficient mice, 4498 
flagellin pretreatment modulates corneal epithelial immune response to, 4664 
role of ST2 in (mouse), 4626 
spantide I in (mouse), 797 
Pseudophakia and neovascular AMD, 1472 
Pseudoxanthoma elasticum with generalized retinal dysfunction, 4250 
Pterygium 
β-catenin and epithelial–mesenchymal transition in pathogenesis of, 1511 
modulation of cholesterol homeostasis by antiproliferative drugs in fibroblasts, 3450 
prognosis-determinant candidate genes in, 3566 
substance P in pathogenesis of, 4482 
Public health impact of neovascular AMD treatments, 96 
Pupillary light reflex 
evaluation of retinal status using chromatic pupil light reflex activity (dog), 5178 
melanopsin-dependent persistence and photopotentiation of (mouse), 1268 
pupil size and retinal straylight, 2375 
Purinergic receptor–mediated regulation of lens connexin43, 4177 
Q
Quality of life 
domain structure assessment of Vision Impairment Questionnaire, 1001 
low-vision rehabilitation and, 1476 
mental effort and independent mobility in glaucoma, 3988 
Quercetin, lens epithelial cell response to DMSO and, 3714 
R
Rab38 gene, ocular hypopigmentation in Rab38cht/cht mice, 3905 
Race/ethnicity 
attitudes of African-Americans about eye examinations, 1989 
biometry of Caucasian and African-American cataractous pediatric eyes, 4671 
contribution of oculometric parameters to refraction by age and ethnicity, 4846 
ethnic differences in impact of parental myopia, 2520 
ethnic differences in macular pigment density and distribution, 3783 
Los Angeles Latino Eye Study, retinopathy in persons without diabetes, 4019 
population differences in elastin maturation in optic nerve head and astrocytes, 3209 
retinal vascular caliber and children’s ethnicity, gender, and birth parameters, 1018 
Radiation therapy, for retinoblastoma, mechanism of tumor cell death after chemotherapy, radiation, and vascular targeting therapy (mouse), 5371 
RAGE ligand, upregulation of VEGF secretion in ARPE-19 cells, 1355 
Rarebit perimetry, 5320 
RASSF1a gene, epigenetic inactivation in uveal melanoma, 486 
RDH12  
phenotype of retinal degeneration in persons with mutations of, 1824 
and RPE65 differ in disease expression, 332 
Reading speed with hand-held magnifier, 4368 
Rectus muscle 
fascicular specialization in (human and monkey), 3089 
horizontal rectus muscle anatomy in strabismic monkeys, 2576 
sideslip of medial rectus muscle during vertical eye rotation, 4527 
REF-1/TFPI-2, analysis of RPE cells exposed to, 516 
Refraction 
contribution of oculometric parameters to refraction by age and ethnicity, 4846 
ocular dominance, laterality, and refraction in Singaporean children, 3533 
simultaneous defocus integration during refractive development (chick), 5352 
Refractive error 
axial length and peripheral refractive error before and after onset of myopia, 2510 
blur adaptation in emmetropia and myopia, 2932 
and cataracts in Lim2 null mice, 500 
choroidal regulation of scleral glycosaminoglycan synthesis during recovery from induced myopia (chick), 2957 
contrast sensitivity and higher-order aberrations after orthokeratology for myopia, 550 
dynamics of accommodative facility in myopes, 4375 
effect of myopia on contrast thresholds, 2371 
effects of foveal ablation on emmetropization and form-deprivation myopia (monkey), 3914 
ethnic differences in impact of parental myopia, 2520 
familial aggregation in Old Order Amish, 4002 
form-deprivation myopia in chick and retinal gene expression, 3430 
genetic mapping of myopia susceptibility loci, 4924 
Heidelberg Retina Tomograph of optic disc and RNFL in Singapore children, 4939 
levels in tree shrew sclera during induced myopia development and recovery, 2947 
linkage replication of MYP12 locus in myopia, 4433 
macular thickness measurements in myopia, 376 
myopia correction and self-reported visual functioning in Mexican children, 4949 
optic disc measurements in myopia with OCT and confocal scanning laser ophthalmoscopy, 3178 
parental myopia and progression of myopia in COMET children, 562 
parental ocular and activity history and future myopia, 3524 
relative axial myopia in Egr-1 knockout mice, 11 
roles of PAX6 and SOX2 in myopia, 4421 
Shihpai Eye Study, correctable visual impairment in elderly Taiwanese, 1032 
and strabismus detection in preschool vision screening, 3115 
temporal constraints on experimental emmetropization in infant monkeys, 957 
treatment of strabismus with axial high myopia, 1132 
Refractive surgery 
functional optical zone of cornea, 1053 
goblet cell density after LASIK procedures, 2570 
impulse activity in corneal sensory nerve fibers after PRK, 4032 
optical zone decentration and aberrations after PRK (cat), 5806 
predicting myopic regression after LASIK, 3516 
wound healing after corneal femtosecond laser keratotomy (rabbit), 2068 
Relative afferent pupillary defect, brightness sensitivity and color perception as predictors of, 3616 
Repetitive transcranial magnetic stimulation, bidirectional modulation of primary visual cortex excitability, 5782 
Resveratrol-induced dilation of porcine retinal arterioles, 4232 
Ret activation does not protect from light-induced damage (mouse), 5199 
Retina 
blood–retinal barrier permeability, retinal thickness, retinal vessel diameter and progression of diabetic macular edema, 3983 
HDL transport of lutein into (chick), 4226 
miRNA expression in human and rat retinas, 3962 
pseudoxanthoma elasticum with generalized retinal dysfunction, 4250 
quail retinal carotenoids, 3976 
retinal hemorrhage in oxygen-induced retinopathy, riluzole inhibition of (rat), 5671 
retinal straylight and pupil size, 2375 
retinopathy in persons without diabetes, 4019 
Retinal degeneration (RD) 
caspase activation by 7-ketocholesterol in retinal neurosensory cells, 1362 
caspase-dependent apoptosis in (rat), 2753 
cellular response to photoreceptor death in (mouse), 849 
CERKL mutation in autosomal recessive RD among Yemenite Jews, 5431 
genetic determinant on mouse chromosome 6, 405 
in GNPTAB deficiency (mouse), 5221 
inherited, high-resolution imaging with adaptive optics in, 3283 
late-onset cone degeneration induced by Rds mutation and gene rescue (mouse), 5397 
macular pigment and lutein supplementation in ABCA4 disease, 1319 
neural reprogramming in (mouse), 3364 
novel form of transducin-dependent RD (mouse), 5445 
novel TULP1 mutation causing Leber congenital amaurosis or early onset RD, 5160 
phenotype in persons with RDH12 mutations, 1824 
VEGF in retinal progenitor cell proliferation in (mouse), 4315 
Retinal detachment 
N-cadherin expression in retinal detachment and reattachment (rat), 1832 
controlling RPE injury after (mouse), 1348 
effect of alkylphosphocholines on intraretinal proliferation in (rabbit), 1305 
glial contributions to retinal detachment–induced photoreceptor degeneration (mouse), 2760 
hyperoxia and oxygen consumption in detached feline retina, 1335 
in vivo retinal tolerance of heavy silicone oils (rabbit), 1873 
Retinal ganglion cells (RGCs) 
calpains in RGC death, 5420 
CaMKIIαB mediates survival response in, 3854 
chemotactic effect of CNTF on macrophages in RGC survival and axonal regeneration (rat), 4257 
differentiation of retinal stem cells transplanted into murine RP models, 446 
double-stranded RNA-dependent protein kinase in ER stress–induced retinal neuron damage, 3729 
IOP-dependent RCG dysfunction in glaucomatous DBA/2J mice, 4573 
mitochondrial fission in differentiated RGC-5 cells, 2145 
neuroprotective effect of erythropoietin on RGCs in glaucoma mice, 1212 
optineurin mutant induces death of, 1607 
oxidative stress in hydrostatic pressure–induced RGC damage, 4580 
pattern ERG monitoring of RGC dysfunction in murine glaucoma, 745 
plasminogen activators cause death of, 1884 
prevention of excitotoxicity in RGCs by (+)pentazocine, 4785 
progressive dysfunction in DBA/2J mouse model of glaucoma, 4564 
retinal phenotypes in mammalian ciliary body after injury of (mouse), 5266 
synaptic contact between melanopsin-containing RGCs and rod bipolar cells (rat), 3812 
transgenic analysis of rodent anterior ischemic optic neuropathy–induced RGC stress and loss (mouse), 2304 
Retinal nerve fiber layer (RNFL) 
defects identified by Stratus OCT in preperimetric glaucoma, 1635 
defects in RP patients, 4748 
Heidelberg Retina Tomograph of optic disc and RNFL in Singapore children, 4939 
heritability of pathologic features in glaucoma, 3669 
imaging comparison of optic disc and RNFL in glaucoma detection, 2644 
OCT and histology of RNFL thickness in glaucoma (monkey), 3645 
peripapillary nerve fiber layer thickness profile with OCT, 3154 
relationship between visual field sensitivity and RNFL thickness measured by OCT, 258 
relationship with perimetry measurements and (monkey), 763 
stronger structure–function relationship with enhanced corneal compensation than with variable corneal compensation in SLP, 1651 (erratum, 1917) 
structure vs. function in glaucoma, 3662 
thickness after acute primary angle closure measured with OCT, 1659 
thinning in autosomal dominant optic atrophy with OPA1 mutations, 4079 
visual field and RNFL measurements in multiple sclerosis, 5798 
Retinal pigment epithelium (RPE) 
analysis of cells exposed to REF-1/TFPI-2, 516 
Bcl-xL in survival of, 3846 
c-Met and EGFR in RPE wound healing, 2242 
caspase-8–mediated apoptosis in, 3341 
controlling RPE injury after experimental retinal detachment (mouse), 1348 
cytotoxicity of triamcinolone acetonide on, 2792 
effect of inflammatory cytokines on RPE proliferation/migration, 5722 
endogenous bone marrow–derived cells express RPE cell markers, 4321 
gene expression profiling of zebrafish embryonic RPE, 881 
glypican 4, bactericidal/permeability-increasing protein in, 5750 
homeostatic regulation of photoreceptor cell integrity (Proctor Lecture), 4866 
IGF in RPE cell tractional force generation, 1892 
in vivo imaging of RPE mosaic in diseased retina, 2297 
JAM-A in corneal endothelium and, 3928 
lipid peroxidation and RPE lysosomal dysfunction, 1342 
MMP-14 and TIMP-2 overexpression protects against oxidant injury in, 5662 
ornithine cytotoxicity in, 464 
positive feedback regulation between MMP-9 and VEGF in, 4360 
posterior pole injury and peripheral RPE proliferation (pig), 355 
protective effect of lipoic acid against acrolein toxicity in, 339 
rapid recruitment of TIP47 in (mouse), 2858 
RPE and CD4 T-cell interaction in T-cell anergy (mouse), 4654 
selective RPE targeting with laser scanner (rabbit), 1782 
somatic ablation of Lrat gene in mouse RPE, 5377 
spermine cytotoxicity in, 455 
thrombin-induced VEGF expression in, 2738 
TRPC channels mediate basal calcium entry in RPE cells, 5767 
vitreous modulation of gene expression in, 1853 
Retinal scatter laser photocoagulation, upregulation of VEGF after (mouse), 5677 
Retinal vessels 
caliber of 
age, blood pressure and, 557 
alternatives to arteriole to venule ratio in measurement of, 52 
blood pressure and retinal arteriole diameter, 328 
children’s ethnicity, gender, birth parameters and, 1018 
complement factor H polymorphism, inflammatory mediators, and retinal vessel diameters, 3014 
progression of diabetic macular edema, 3983 
relation to optic disc and cup diameters, 63 
relationship with optic disc diameter in children, 4945 
carbonic anhydrase inhibitor–induced relaxation of porcine retinal arterioles, 4688 
G6PD in retinal vein occlusion, 2747 
HGF in retinal angiogenesis, 1793 
hyperhomocysteinemia and low methionine stress as risk factors for central retinal venous occlusion, 1441 
in vivo retinal immunostaining demonstrates macrophage association with growing and regressing vessels, 4335 
interferon effect on retinal microcirculation, 368 
loss of insulin-mediated vasoprotection (rat), 2350 
resveratrol-induced dilation of porcine retinal arterioles, 4232 
retinal oxygen metabolism in retinal artery occlusion (rat), 2290 
retinal vascular network geometry and cognitive ability in elderly population, 1995 
simvastatin-induced dilation of porcine retinal arterioles, 825 
vascular reactivity in diabetic retinopathy, 1744 
Retinitis pigmentosa (RP) 
ABCA4 mutations in severe retinopathies in Spanish patients, 985 
central retinal function in advanced RP, 1312 
CNTF-induced cellular changes in (mouse), 1389 
differentiation of retinal stem cells transplanted into murine RP models, 446 
disease course of patients with X-linked RP due to RPGR mutations, 1298 
identifying novel mutations in Leber congenital amaurosis and juvenile RP, 5690 
inner retinal abnormalities in X-linked RP with RPGR mutations, 4759 
multifocal ERG patterns of cone degeneration in, 383 
novel mutation in carbonic anhydrase IV gene that causes RP, 3459 
population study of X-linked RP, 4012 
preservation of macular oscillatory potentials in, 3312 
PRPF31 mutations in autosomal dominant RP, 1330 
repeatability of Humphrey perimetry in patients with, 4720 
restoration of visual responses in aged dystrophic rats after channelopsin-2 gene transfer, 3821 
Ret activation does not protect from light-induced damage (mouse), 5199 
RNFL defects in patients with, 4748 
Retinoblastoma 
antitumor action of neurokinin-1 receptor antagonist, 2775 
bortezomib-induced apoptosis in human retinoblastoma cell lines, 4706 
KIF14 expression and age at diagnosis of, 4901 
mechanism of tumor cell death after chemotherapy, radiation, and vascular targeting therapy (mouse), 5371 
paclitaxel treatment in murine model, 3437 
topotecan vitreous levels after periocular or intravenous delivery (rabbit), 3761 
tumor vessel maturation (mouse), 2476 
Retinoic acids, in cataractogenesis, 2224 
Retinopathy of prematurity (ROP) 
changes in pericytes and smooth muscle cells in kitten model of, 1368 
high-resolution manganese-enhanced MRI of experimental ROP (rat), 4733 
oscillatory potentials of dark-adapted ERG in (rat), 5788 
rod function predicts blood vessel abnormality in (rat), 4351 
scotopic visual thresholds in, 4854 
Retinoschisin 
expression profiling of retinoschisin-deficient retina in postnatal mouse development, 891 
gene therapy in Rs1h-KO mouse, 3837 
in murine retina, 991 
RS1 mutants associated with X-linked retinoschisis, 2491 
Rho-associated protein kinase inhibitor, antiscarring effects of Y-27632 in glaucoma filtration surgery (rabbit), 5549 
Rhodopsin 
light exposure, photoreceptor degeneration, and AP-1 activation (dog), 4907 
novel form of transducin-dependent RD (mouse), 5445 
sensitivity to light-induced damage in autosomal dominant retinal disease (mouse), 1942 (erratum, 3436) 
truncated rhodopsin in rod function and degeneration (moue), 2868 
Rhodopsin kinase 
AAV-mediated expression targeting of rods and cones with human rhodopsin kinase promoter (mouse), 3954 
signaling in Tenon’s capsule fibroblasts, 2152 
Riboflavin-UVA–induced collagen cross-linking and IOP measurement, 5494 
Riluzole, inhibition of retinal hemorrhage in oxygen-induced retinopathy (rat), 5671 
RLBP1 gene promotor, identification of, 3872 
RNA 
microRNAs expressed in mouse eye, 509 
miRNA expression in human and rat retinas, 3962 
RNA-dependent protein kinase in ER stress–induced retinal neuron damage, 3729 
Rods. See Photoreceptors 
Rotterdam Study, complement factor H polymorphism, inflammatory mediators, and retinal vessel diameters, 3014 
RPE65  
essential for cone function in NRL-deficient mice, 534 
and RDH12 differ in disease expression, 332 
RPGR gene mutations 
disease course of patients with X-linked RP due to, 1298 
inner retinal abnormalities in X-linked RP with, 4759 
RTEF-1, novel alternatively spliced isoforms in endothelial cells and murine retina, 3775 
S
Safety issues 
coated microneedles for drug delivery, 4038 
preclinical safety evaluation of intravitreal VEGF antibody injection (rabbit), 1773 
risk of falls and motor vehicle collisions in glaucoma, 1149 
Salisbury Eye Evaluation 
visual field loss and risk of falls in older adults, 4445 
visual impairment and motor vehicle crashes among older drivers, 1483 
Sarcoidosis, HSP-70/Hom gene polymorphisms and uveitis in patients with, 3019 
Scanning laser polarimetry (SLP) 
effect of atypical birefringence patterns on glaucoma detection using SLP with variable corneal compensation, 223 
with enhanced corneal compensation, for glaucoma detection, 3146 
and OCT in normal and glaucomatous eyes, 2099 
repeatability in glaucoma, 1156 
stronger structure–function relationship with enhanced corneal compensation than with variable corneal compensation in, 1651 (erratum, 1917) 
Scavenger receptors for oxidized lipoprotein in AMD, 1801 
Schnyder crystalline corneal dystrophy, UBIAD1 mutations in, 5007 
Schwann cell transplantation preserves vision without immunosuppression (rat), 1906 
Sclera 
choroidal regulation of scleral glycosaminoglycan synthesis during recovery from induced myopia (chick), 2957 
levels in tree shrew sclera during induced myopia development and recovery, 2947 
MMP enhancement of transscleral permeability, 752 
Scotopic visual thresholds in ROP, 4854 
Second-harmonic imaging microscopy of corneas, 1087 
Shihpai Eye Study, correctable visual impairment in elderly Taiwanese, 1032 
Signal transduction 
activation of BMP canonical signaling pathway, 5058 
cyclic ADP-ribose–dependent calcium signaling pathway in bovine rod outer segments, 978 
endothelin-1–mediated signaling in expression of MMPs and TIMPs in astrocytes, 3737 
glucocorticoid receptor activation and signal transduction pathways in lens epithelial cells, 1724 
lysophosphatidic acid and EGFR signaling in corneal wound healing, 636 
notch signaling in corneal epithelial cell differentiation and proliferation, 3576 
p38 MAP kinase pathway and stromelysin regulation in trabecular meshwork cells, 3126 
regulation of IL-8 by S. aureus in conjunctival cells, 270 
Rho-kinase signaling in Tenon’s capsule fibroblasts, 2152 
Src suppression blocks posterior capsule opacification (chick), 2214 
upregulation of TGF-β–induced tissue transglutaminase in subconjunctival fibroblasts, 1952 
Wnt signaling during photoreceptor degeneration, 5733 
Simvastatin-induced dilation of porcine retinal arterioles, 825 
SIRT1 neuroprotection in experimental optic neuritis (mouse), 3602 
Sjögren syndrome 
dacryoadenitis in IL-4 deficient MRL/MpJ mice, 5624 
in vivo confocal study of cornea in, 2017 
Slit lamp–simulated oblique flashlight test in Chinese eyes, 5459 
Slug, TGF-β1 repression of E-cadherin via Slug expression in lens epithelium, 2708 
SMCT1 and SMCT2 expression in retina, 3356 
Smoking, CFH gene variants, and AMD risk in Japanese population, 5315 
Smooth muscle cells, and pericytes in ROP (kitten), 1368 
SOD2 knockdown mouse model of early AMD, 4407 
Sodium 4-phenylbutyrate corrects myocilin misfolding in glaucoma, 1683 
Sodium-coupled monocarboxylate transporter expression in retina, 3356 
Somatostatin receptor 2, antiangiogenic effect (mouse), 3480 
SOX2, role in myopia, 4421 
Sp1 
laminin regulation of α6 integrin gene expression by altering level of Sp1 and Sp3, 3490 
PAF and repressor effect of Sp1 in expression of MMP-9 in corneal epithelial cells, 1931 
Spantide I, in Pseudomonas aeruginosa keratitis (mouse), 797 
Spatial frequency selectivity of human motion system, 3897 
Spectacles, multifocal, and tripping in the elderly, 1466 
Spermine cytotoxicity in RPE cells, 455 
Src suppression blocks posterior capsule opacification (chick), 2214 
ST2, role in Pseudomonas keratitis (mouse), 4626 
Staphylococcus  
age-related differences in experimental S. aureus keratitis (rabbit), 5125 
genetic variations among ocular isolates of S. epidermidis, 3239 
regulation of IL-8 by S. aureus in conjunctival cells, 270 
Stargardt disease 
eccentric fixation assessed by Tübingen perimetry, 5815 
homozygosity for novel ABCA4 founder splicing mutation associated with, 4308 
macular pigment and lutein supplementation in ABCA4 disease, 1319 
Statins 
atorvastatin inhibition of choroidal neovascularization (mouse), 1839 
simvastatin-induced dilation of porcine retinal arterioles, 825 
Stem cells 
circulating hematopoietic stem cells in neovascular AMD, 5464 
differentiation of retinal stem cells transplanted into murine RP models, 446 
limbal 
fate during ex vivo expansion, 605 
phenotype of, 144 
secretion of cornea-like tissue in vitro by, 5038 
Strabismus 
acute superior oblique palsy 
change in static eye alignment in (monkey), 2602 
changes in dynamic properties during vertical saccades (monkey), 2612 
relationship to Listing’s law (monkey), 2621 
with axial high myopia, 1132 
binocular summation of contrast in strabismic amblyopia, 5332 
cross-axis eye movements in primates with A pattern strabismus, 665 
detection in preschool vision screening, 3115 
horizontal rectus muscle anatomy in strabismic monkeys, 2576 
horizontal saccade disconjugacy in strabismic monkeys, 3107 
oculomotor nerve in congenital fibrosis of EOMs and congenital oculomotor palsy, 1601 
slow-releasing tranilast in PTFE/PLGA after strabismus surgery (rabbit), 699 
Streptococcus pneumoniae, cholesterol treatment for pneumococcal keratitis (rabbit), 2661 
Stromelysin, p38 MAP kinase pathway and stromelysin regulation in trabecular meshwork cells, 3126 
Subretinal prosthetic, functional assessment of (rat), 916 
Substance P, in pathogenesis of pterygia, 4482 
Superior oblique palsy, acute 
change in static eye alignment in (monkey), 2602 
changes in dynamic properties during vertical saccades (monkey), 2612 
relationship to Listing’s law (monkey), 2621 
Superoxide dismutase, mitochondrial oxidative damage and diabetic retinopathy (mouse), 3805 
Suprachoroidal-transretinal stimulation, optical imaging of retina activated by (cat), 4777 
Suprathreshold contrast matching in maculopathy, 3419 
Surfactant proteins A and D, in human tear fluid and lacrimal system, 3945 
Sydney Myopia Study, contribution of oculometric parameters to refraction by age and ethnicity, 4846 
T
T lymphocytes 
CD8 regulatory T cells in experimental autoimmune uveitis (mouse), 2178 
expression of Th-1 chemokines and receptors in mouse model of dry eye, 2561 
IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in EAU (mouse), 4153 
modulation of CD8+ cytotoxic T lymphocyte effector function by fibroblasts derived from immunoprivileged cornea (mouse), 2194 
regulatory T cells enhance retinal graft survival (mouse), 5112 
RPE and CD4 T-cell interaction in T-cell anergy (mouse), 4654 
viral antigens recognized by T cells in varicella zoster virus–induced uveitis, 3689 
TACSTD2 mutations, in gelatinous drop-like corneal dystrophy, 4490 
Tear film 
decompression-induced ocular tear film bubbles, 3756 
effect of blinking on tear dynamics, 3032 
fatty acids in meibomian gland secretions, 34 
ocular surface: challenge to enable and protect vision (Friedenwald Lecture), 4391 
surfactant proteins A and D in human tear fluid and lacrimal system, 3945 
trypsin inhibitory capacity in vernal keratoconjunctivitis, 264 
Technology, electronic medical records system for clinical research and the EMR–EDC interface (new developments), 4383 
Temporal artery biopsy, sensitivity of, 675 
Tenon’s capsule fibroblasts 
IFN-α and IFN-γ sensitize fibroblasts to mitomycin-C, 3655 
Rho-kinase signaling in, 2152 
The Gambia, bacterial infection and trachoma in, 4440 
Thrombin 
corneal prothrombin activation to form, 134 
inhibition of intercellular Ca2+ wave propagation in corneal endothelial cells by, 120 
thrombin-induced VEGF expression in RPE cells, 2738 
Thymosin β-4, antiapoptotic effects on corneal epithelial cells, 27 
Thyroid hormone 
influence on lacrimal gland and ocular surface morphology (rat), 3038 
thyroxine-ameliorated oxidative stress in lens epithelial cells, 3698 
TIP47, rapid recruitment in RPE (mouse), 2858 
Tissue engineering 
innervation of tissue-engineered corneal implants (pig), 3537 
transplantable rabbit carrier-free epithelial sheets, 597 
Tissue inhibitors of matrix metalloproteinase (TIMPs) 
endothelin-1–mediated signaling in expression of MMPs and TIMPs in astrocytes, 3737 
MMP-14 and TIMP-2 overexpression protects against oxidant injury in RPE, 5662 
MMP and TIMP expression in human lens cells, 4192 
Tissue transglutaminase, expression in subconjunctival fibroblasts, 1952 
Tobramycin, phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops vs. 0.3% tobramycin eye drops for bacterial conjunctivitis, 3425 
Toll-like receptors (TLRs) 
in acute anterior uveitis, 1711 
TLR-3 and -9 in human corneal myofibroblasts, 3069 
Topographic angiography, in classic and occult choroidal neovascularization, 1751 
Topography, corneal 
influence of eyelid morphology on corneal shape, 112 
3-D atlas of corneal shape, 1072 
Topotecan, vitreous levels after periocular or intravenous delivery for retinoblastoma (rabbit), 3761 
Trabecular meshwork (TM) 
actin cytoskeletal integrity and MMP-2 activation in, 2105 
BMP-7 is antagonist of TGF-β2 in, 715 
ECM gene alternative splicing by TM cells in response to mechanical stretching, 1164 
effects of TGF-β2, BMP-4, and gremlin in, 1191 
elevated alkaline phosphatase in glaucomatous TM, 3184 
lactate causes NF-κB activation and CD44 shedding in cultured TM cells, 1615 
p38 MAP kinase pathway and stromelysin regulation in, 3126 
synergism of cytokine induction of MMP-3 in, 2634 
Trachoma 
and bacterial infection in The Gambia, 4440 
mass treatment of ocular Chlamydia trachomatis and, 1492 
Tranilast, slow-releasing tranilast in PTFE/PLGA after strabismus surgery (rabbit), 699 
Transcorneal electrical stimulation 
effect in acute-phase optic nerve injury (rat), 2356 
protection of photoreceptors by (rat), 4725 
Transcranial direct current stimulation, bidirectional modulation of primary visual cortex excitability, 5782 
Transducin 
light threshold–controlled cone α−transducin translocation, 3350 
transducin-dependent RD (mouse), 5445 
Transforming growth factor-β (TGF-β) 
BMP-7 is antagonist of TGF-β2 in TM cells, 715 
effects of TGF-β2, BMP-4, and gremlin in TM, 1191 
inhibition of corneal epithelial TGF-β2 production by extracellular matrix, 1061 
repression of E-cadherin via Slug expression in lens epithelium, 2708 
upregulation of TGF-β–induced tissue transglutaminase in subconjunctival fibroblasts, 1952 
Transient receptor potential (TRP) channels, TRPC channels mediate basal calcium entry in RPE cells, 5767 
Transplantation 
amniotic membrane, sutureless, for ocular surface reconstruction, 1528 
corneal 
allergic conjunctival inflammation and allogeneic response to donor cornea, 4044 
CCR1 deletion prolongs allograft survival (mouse), 1228 
corneal innervation and cellular changes after, 621 
episcleral cyclosporine implant for keratoplasty rejection, 2023 
NGF gene therapy improves allograft survival (rat), 1043 
photo cross-linkable biodendrimers as ophthalmic adhesives for, 2037 
cultivated corneal endothelial cell sheet transplantation (monkey), 4519 
regulatory T cells enhance retinal graft survival (mouse), 5112 
Schwann cell transplantation preserves vision without immunosuppression (rat), 1906 
transplantable rabbit carrier-free epithelial sheets, 597 
Trauma, ocular, manganese-enhanced MRI studies of intraretinal ion demand in (rat), 3796 
Travoprost, in vitro studies of antiglaucomatous prostaglandin analogues, 4123 
Treatment adherence, pharmacy claims data to study glaucoma medication adherence, 5052 
Triamcinolone acetonide 
cytotoxicity on RPE cells, 2792 
effects on leukocyte–endothelium interactions in ischemic retina (rat), 2831 
intravitreal, retinal toxicity of (rabbit), 390 
oxidative injury mediated by, compared with dexamethasone, 5742 
Trypsin, inhibitory capacity in vernal keratoconjunctivitis, 264 
Tubby-like protein 1, interaction with dynamin-1 (mouse), 2837 
Tübingen perimetry, eccentric fixation in Stargardt’s disease assessed by, 5815 
TULP1 mutation causing Leber congenital amaurosis or early onset RD, 5160 
Tumor necrosis factor-α (TNF-α) 
apoptosis in murine CMV retinitis induced by, 1691 
endogenous TNF-α suppression of neovascularization in corneal stroma (mouse), 3051 
role of soluble TNF receptors for TNF-α in uveitis, 3246 
synergism of cytokine induction of MMP-3 in TM, 2634 
Tumors 
primary intraocular lymphoma 
IL-10 measurement in aqueous humor in screening for, 3253 
Th1/Th2 cytokine profile (mouse), 3223 
retinoblastoma 
antitumor action of neurokinin-1 receptor antagonist, 2775 
bortezomib-induced apoptosis in human retinoblastoma cell lines, 4706 
KIF14 expression and age at diagnosis of, 4901 
mechanism of tumor cell death after chemotherapy, radiation, and vascular targeting therapy (mouse), 5371 
paclitaxel treatment in murine model, 3437 
topotecan vitreous levels after periocular or intravenous delivery (rabbit), 3761 
tumor vessel maturation (mouse), 2476 
screening and diagnosis of optic pathway gliomas in children, 2895 
uveal melanoma 
APITD1 expression and, 4919 
BMP-7 inhibits growth of, 4882 
direct-infection model of early hepatic metastasis, 4399 
epigenetic inactivation of RASSF1a in, 486 
manganese-enhanced MRI of choroidal melanoma xenografts (rat), 963 
melanocortin 1 receptor expression in, 1219 
modeling behavior of, in mouse liver, 2967 
molecular characteristics of liver metastases from, 4890 
monosomy 3 and vasculogenic mimicry in, 1918 
promoter methylation status of multiple genes in, 4403 
T1799A BRAF mutation in iris melanoma, 4897 
Twin studies 
heredity of small hard drusen in twins aged 20–46 years, 833 
heritable features of optic disc, 2469 
inheritance of peripapillary atrophy, 2529 
U
UBIAD1 mutations in Schnyder crystalline corneal dystrophy, 5007 
Ultrasonography and MRI of retrobulbar human optic nerve, 1913 
Ultraviolet (UV) radiation exposure 
p53 expression and lens apoptosis after (rat), 4187 
protective effect of caffeine against UV-induced apoptosis in corneal epithelial cells, 652 
protein-bound UV filters in normal human lenses, 1718 
riboflavin-UVA–induced collagen cross-linking and IOP measurement, 5494 
Uridine, protective effects on cornea in rabbit dry eye model, 1102 
Uveal melanoma 
APITD1 expression and, 4919 
BMP-7 inhibits growth of, 4882 
direct-infection model of early hepatic metastasis, 4399 
epigenetic inactivation of RASSF1a in, 486 
manganese-enhanced MRI of choroidal melanoma xenografts (rat), 963 
melanocortin 1 receptor expression in, 1219 
modeling behavior of, in mouse liver, 2967 
molecular characteristics of liver metastases from, 4890 
monosomy 3 and vasculogenic mimicry in, 1918 
promoter methylation status of multiple genes in, 4403 
T1799A BRAF mutation in iris melanoma, 4897 
Uveitis 
acute anterior, toll-like receptors in, 1711 
endotoxin-induced 
aldose reductase in (rat), 4634 
attenuation by cholinergic agonist (rat), 2719 
downregulation by intravitreal VIP encapsulated in liposomes (rat), 3230 
experimental autoimmune (EAU) 
CD8 regulatory T cells in (mouse), 2178 
IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in (mouse), 4153 
role of apoptosis in resolution of (rat), 5019 
suppression by anti-LFA-1α Ab (mouse), 2667 
HSP-70/Hom gene polymorphisms and uveitis in patients with sarcoidosis, 3019 
role of soluble TNF receptors for TNF-α in, 3246 
varicella zoster virus–induced, viral antigens in, 3689 
V
Vaccines 
lipopeptide vaccines to prevent ocular herpes infection, 4643 
macrophages as determinants of ocular HSV-1 infection in immunized mice, 5605 
oral immunization for Acanthamoeba keratitis (hamster), 5597 
suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2 (mouse), 4795 
Valsartan, amelioration of retinal dysfunction in diabetic rats, 927 
Varicella zoster virus–induced uveitis, viral antigens in, 3689 
Vascular endothelial growth factor (VEGF) 
antiangiogenic effect of somatostatin receptor 2 (mouse), 3480 
effect of VEGF-A on expression of profibrotic growth factor and ECM genes in retina (rat), 4267 
endogenous TNFα suppression of neovascularization in corneal stroma (mouse), 3051 
memantine effects in diabetic retinopathy (rat), 5152 
positive feedback regulation between MMP-9 and VEGF in RPE cells, 4360 
preclinical safety evaluation of intravitreal VEGF antibody injection (rabbit), 1773 
RAGE ligand upregulation of VEGF secretion in ARPE-19 cells, 1355 
in retinal progenitor cell proliferation in murine retinal degeneration, 4315 
synergies of VEGF inhibition and PDT in AMD, 1767 
thrombin-induced VEGF expression in RPE cells, 2738 
upregulation after retinal scatter laser photocoagulation (mouse), 5677 
Vascular endothelial growth factor receptor 2 (VEGFR2), suppression of choroidal neovascularization by dendritic cell vaccination targeting (mouse), 4795 
Vasculature. See also Endothelial cells; Neovascularization 
age, blood pressure, and retinal vessel diameter, 557 
alternatives to arteriole to venule ratio in measuring retinal vascular caliber, 52 
aquaporin-1–independent microvessel proliferation in murine oxygen-induced retinopathy, 4802 
bevacizumab inhibition of corneal angiogenesis and lymphangiogenesis (mouse), 2545 
blood pressure and retinal arteriole diameter, 328 
blood–retinal barrier permeability, retinal thickness, retinal vessel diameter and progression of diabetic macular edema, 3983 
capillary degeneration in ischemia/reperfusion injury (rat), 361 
carbonic anhydrase inhibitor–induced relaxation of porcine retinal arterioles, 4688 
complement factor H polymorphism, inflammatory mediators, and retinal vessel diameters, 3014 
G6PD in retinal vein occlusion, 2747 
HGF in retinal angiogenesis, 1793 
hyperhomocysteinemia and low methionine stress as risk factors for central retinal venous occlusion, 1441 
inhibition of angiogenesis by intraceptor nanoparticles (mouse), 2030 
in vivo retinal immunostaining demonstrates macrophage association with growing and regressing vessels, 4335 
interferon effect on retinal microcirculation, 368 
loss of insulin-mediated vasoprotection (rat), 2350 
relation of retinal vessel caliber to optic disc and cup diameters, 63 
relationship of retinal vascular caliber with optic disc diameter in children, 4945 
resveratrol-induced dilation of porcine retinal arterioles, 4232 
retinal oxygen metabolism in retinal artery occlusion (rat), 2290 
retinal vascular caliber and children’s ethnicity, gender, and birth parameters, 1018 
retinal vascular network geometry and cognitive ability in elderly population, 1995 
rod function predicts blood vessel abnormality in ROP (rat), 4351 
sensitivity of temporal artery biopsy, 675 
simvastatin-induced dilation of porcine retinal arterioles, 825 
vascular reactivity in diabetic retinopathy, 1744 
Vasoactive intestinal peptide (VIP), downregulation of endotoxin-induced uveitis by intravitreal VIP encapsulated in liposomes (rat), 3230 
Vegetable oil vectors, cytotoxicity evaluation of, 5000 
Vernal keratoconjunctivitis, trypsin inhibitory capacity in, 264 
Verteporfin PDT, neurotrophic factors minimize renal toxicity of (rat), 430 
Vestibulo-ocular reflex, initial misdirection, 5512 
Vision screening 
attitudes of African-Americans about eye examinations, 1989 
children unable to perform screening tests in Vision in Preschoolers Study, 83 
screening and treating amblyopia, 2084 
strabismus detection in preschool children, 3115 
visual acuity measurement in Chinese reading population, 2383 
Visual acuity 
acuity development in infantile nystagmus, 4093 
computer-based test for optimal visual acuity in AMD, 4838 
macular pigment: test of acuity hypothesis, 2922 
measurement in Chinese reading population, 2383 
myopia correction and self-reported visual functioning in Mexican children, 4949 
optical factors and resolution acuity in children with Down syndrome, 3995 
perceptual learning and recovery of visual acuity in juvenile amblyopia, 5046 
public health impact of neovascular AMD treatments, 96 
Rasch analysis of Daily Living Tasks Dependent on Vision, 1976 
screening and treating amblyopia, 2084 
Visual adaptation to interocular brightness differences, 935 
Visual cortex 
bidirectional modulation of primary visual cortex excitability, 5782 
defects in amblyopia, 1575 
organization and optic disc damage in glaucoma, 733 
retinotopic organization of primary visual cortex in glaucoma, 733 
Visual evoked potentials (VEPs) 
abnormal waveform of human pattern VEP: gamma oscillatory components, 4534 
effect of transcorneal electrical stimulation in acute-phase optic nerve injury (rat), 2356 
glaucoma detection with dichoptic multifocal VEPs, 4590 
heterogeneity of lesions in optic neuritis, 4549 
improved conduction velocity after optic neuritis, 692 
motion-detection asymmetries in esotropic and normal infants, 5523 
multifocal VEP vs. standard automated perimetry in ocular hypertension and glaucoma, 1173 
restoration of visual responses in aged dystrophic rats after channelopsin-2 gene transfer, 3821 
in screening and diagnosis of optic pathway gliomas in children, 2895 
spatial luminance contrast sensitivity measured with transient VEP, 3396 
validation study of VEP Vernier acuity in adults, 4070 
Visual field defects 
fellow eye losses in asymmetric glaucoma, 2626 
novel spatial filter to monitor glaucomatous visual field progression, 251 
progression determined by Monte Carlo simulation in glaucoma, 1642 
relationship between visual field sensitivity and RNFL thickness measured by OCT, 258 
and risk of falls in older adults, 4445 
Visual field testing 
decreasing test–retest variability in glaucoma, 1627 
eccentric fixation in Stargardt’s disease assessed by Tübingen perimetry, 5815 
multifocal VEP vs. standard automated perimetry in ocular hypertension and glaucoma, 1173 
visual field and RNFL measurements in multiple sclerosis, 5798 
visual field clustering with machine learning classifiers, 5582 
Visual impairment/loss 
accommodation in pre-presbyopes with, 3888 
CNTF reduces vision in rats in dose-dependent manner, 5756 
domain structure assessment of Vision Impairment Questionnaire, 1001 
importance and difficulty of driving in low-vision population, 4955 
low-vision rehabilitation and quality of life, 1476 
optokinetic nystagmus in severely visually impaired patients, 4542 
residual visual function after loss of both cerebral hemispheres in infancy, 3098 
role in motor vehicle crashes among older drivers, 1483 
Shihpai Eye Study, correctable visual impairment in elderly Taiwanese, 1032 
and visual hallucinations in AMD, 1416 
Visual masking, spatial frequency selectivity of human motion system revealed by, 3897 
Visual spatial integration in elderly persons, 2940 
Visual system vulnerability to prenatal endotoxin exposure (sheep), 472 
Vitamin E, retina in αTTP null mice fed diet deficient in, 396 
Vitrectomy 
aerosol drug delivery during, 5243 
polylactic acid for visualizing vitreous body during (rabbit), 3277 
Vitreous 
histogenesis of intravitreal membrane and secondary vitreous (mouse), 1923 
modulation of gene expression in RPE cells, 1853 
multiplex bead analysis of vitreous humor, 2203 
persistent hyperplastic primary vitreous due to somatic mosaic deletion of Arf (mouse), 491 
Voriconazole, intravitreal, clearance of (rabbit), 2238 
W
Wnt signaling during photoreceptor degeneration, 5733 
Wound healing 
corneal 
after corneal femtosecond laser keratotomy (rabbit), 2068 
carboxymethylcellulose in, 1559 
CD18 integrins and neutrophil–keratocyte interactions during (mouse), 5023 
in diabetic Goto-Kakizaki rat, 590 
laser-activated solder for sealing corneal wounds, 1038 
light-scattering and ultrastructure of healed penetrating wounds (rabbit), 157 
lysophosphatidic acid and EGFR signaling in, 636 
photo cross-linkable biodendrimers as ophthalmic adhesives for wound repair, 2037 
RPE, c-Met and EGFR in, 2242 
X
X-linked retinoschisis, RS1 mutants associated with, 2491 
Y
Y-27632, antiscarring effects in glaucoma filtration surgery (rabbit), 5549 
Y-39983, topical, effects on ocular tissues in rabbits and monkeys, 3216 
Z
Zeaxanthin 
HDL transport into retina (chick), 4226 
and lutein protect photoreceptors from oxidative stress–induced apoptosis, 5168 
macular pigment optical density and carotenoids in diet and serum, 571 
Zernike terms in keratoconus, magnitude and orientation of, 3062 
ZO-1, localization in nucleolus of corneal fibroblasts, 2043 
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