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Hiroaki Nishihara, Mineo Kondo, Kohei Ishikawa, Tadasu Sugita, Chang-Hua Piao, Yoshiharu Nakamura, Hiroko Terasaki; Focal Macular Electroretinograms in Eyes with Wet-type Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(7):3121-3125. doi: 10.1167/iovs.08-1835.
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purpose. To study the properties of the focal macular electroretinograms (fmERGs) in eyes with untreated wet-type age-related macular degeneration (AMD).
methods. fmERGs were recorded from 157 eyes of 157 consecutive patients with untreated wet-type AMD (113 men, 44 women; age, 71.3 ± 8.0 years). The fmERGs were recorded under direct fundus observation using a modified infrared fundus camera and a 15° stimulus spot. Amplitudes and implicit times of the fmERGs recorded from the AMD patients were compared with those from 21 age-similar healthy controls.
results. The amplitudes of fmERGs in the AMD patients were significantly smaller (P < 0.001) and the implicit times were significantly longer (P < 0.001) than the corresponding values in the control eyes. There was a significant correlation between amplitude and implicit time of the fmERG and visual acuity (logMAR), but the degree of correlation was weak. The difference in the b/a amplitude ratio between the AMD patients and healthy controls was not significant.
conclusions. The significant reduction in amplitude and the severe delay in implicit times of a- and b-waves of the fmERGs indicated significant functional alterations in the inner and the outer retinal layers of the macular area of eyes with wet-type AMD.
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