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Richard Y. Hwang, Daniel J. Gauthier, Dana Wallace, Natalie A. Afshari; Refractive Changes after Descemet Stripping Endothelial Keratoplasty: A Simplified Mathematical Model. Invest. Ophthalmol. Vis. Sci. 2011;52(2):1043-1054. doi: 10.1167/iovs.10-5839.
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To develop a mathematical model that can predict refractive changes after Descemet stripping endothelial keratoplasty (DSEK).
A mathematical formula based on the Gullstrand eye model was generated to estimate the change in refractive power of the eye after DSEK. This model was applied to four DSEK cases retrospectively, to compare measured and predicted refractive changes after DSEK.
The refractive change after DSEK is determined by calculating the difference in the power of the eye before and after DSEK surgery. The power of the eye post-DSEK surgery can be calculated with modified Gullstrand eye model equations that incorporate the change in the posterior radius of curvature and change in the distance between the principal planes of the cornea and lens after DSEK. Analysis of this model suggests that the ratio of central to peripheral graft thickness (CP ratio) and central thickness can have significant effect on refractive change where smaller CP ratios and larger graft thicknesses result in larger hyperopic shifts. This model was applied to four patients, and the average predicted hyperopic shift in the overall power of the eye was calculated to be 0.83 D. This change reflected in a mean of 93% (range, 75%–110%) of patients' measured refractive shifts.
This simplified DSEK mathematical model can be used as a first step for estimating the hyperopic shift after DSEK. Further studies are necessary to refine the validity of this model.
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