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Nishani Amerasinghe, Paul J. Foster, Tien Yin Wong, Hla Myint Htoon, Mingguang He, Sunny Y. Shen, Han T. Aung, Seang-Mei Saw, Tin Aung; Variation of Angle Parameters in Asians: An Anterior Segment Optical Coherence Tomography Study in a Population of Singapore Malays. Invest. Ophthalmol. Vis. Sci. 2009;50(6):2626-2631. doi: https://doi.org/10.1167/iovs.08-2582.
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purpose. To assess variations in angle parameters using anterior segment optical coherence tomography (AS-OCT) and to investigate demographic, ocular and systemic associations of angle width.
methods. This was a substudy of a population based, cross-sectional survey of 3280 (78.7% response rate) Malay people aged 40 to 80 years in Singapore. All participants underwent a standardized interview and ocular and systemic examination. AS-OCT was performed on 291 consecutive patients in standardized dark conditions. Angle opening distance (AOD-500) and trabecular–iris space area (TISA-500) 500 μm from the scleral spur were determined for the nasal and temporal angles. Anterior chamber depth (ACD) was also measured.
results. AS-OCT measurements were analyzed in 239 (82.1%) right eyes. Mean AOD 500 was smaller in women than in men, both nasally (0.255 vs. 0.293 mm, P = 0.026) and temporally (0.245 vs. 0.286 mm, P = 0.023). Mean TISA-500 was smaller in women in the nasal quadrant only (0.104 vs. 0.117 mm, P = 0.035). Mean ACD was smaller in women than in men (2.71 vs. 2.87 mm, P = 0.001). Multiple linear regression showed that axial length and ACD were significantly associated with AOD-500 and TISA-500 both nasally (adjusted R 2 = 0.34 for AOD-500 and 0.20 for TISA-500) and temporally (adjusted R 2 = 0.35 for AOD-500 and 0.24 for TISA-500). Body mass index, HbA1c, systolic blood pressure, intraocular pressure, cup-to-disc ratio, and central corneal thickness were not significantly associated with AOD-500, TISA-500, or ACD.
conclusions. In this Malay population, angle width measured by AS-OCT was smaller in women than in men, and in eyes with shorter axial length and shallower ACD.
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