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Won Kyung Song, Sung Chul Lee, Eun Suk Lee, Chan Yun Kim, Sung Soo Kim; Macular Thickness Variations with Sex, Age, and Axial Length in Healthy Subjects: A Spectral Domain–Optical Coherence Tomography Study. Invest. Ophthalmol. Vis. Sci. 2010;51(8):3913-3918. doi: https://doi.org/10.1167/iovs.09-4189.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain–optical coherence tomography (SD-OCT).
One randomly selected eye of 198 consecutive ophthalmically normal subjects (104 men, 94 women) between July 2008 and January 2009, with corrected visual acuities better than 20/30 were included in this cross-sectional study. Complete ophthalmic examination, axial length measurement with a laser interferometer, and macular cube 512 × 128 scan by SD-OCT were performed.
The mean age was 55.6 ± 16.4 years (range, 17–83), average refractive error was −2.17 ± 4.82 (range, −23.50–3.75), and average axial length was 24.73 ± 1.98 mm (range, 21.52–32.51). The central subfield thickness, average inner macular thickness, and overall macular volume were significantly lower in the female subjects (partial correlation: P = 0.009, P = 0.027, and P = 0.042, respectively). As age increased, average inner macular thickness, average outer macular thickness, overall average macular thickness, and macular volume decreased significantly (partial correlation: P = 0.002, P = 0.002, P = 0.002, and P = 0.000, respectively). Refractive error had no significant influence in partial correlation analysis. Axial length correlated negatively with average outer macular thickness, overall average macular thickness, and macular volume (partial correlation: P = 0.006, P = 0.044, and P = 0.003, respectively).
In normal subjects, SD-OCT showed that retinal thickness is related to age, sex, and axial length, with regional variations.
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