After fixation in a Davidson solution, the eyes were dehydrated in alcohol solutions of increasing concentration, cleared in xylene, and embedded in paraffin. They were sectioned coronally in two parts (one rostral, one caudal). The rostral portion was further sectioned in the coronal plane encompassing the ciliary processes. The lens was detached during sectioning and then removed. At least 20 serial sections (5-μm-thick, every 100 μm) through the ciliary bodies were cut on a microtome (HM 355 S; Microm, Francheville, France) and then stained with safranin-hematoxylin-eosin. Additional sections were performed when necessary to cut throughout the ciliary body. The caudal portion of the eyes was further cut in a parasagittal plane to delimit a slice encompassing the optic nerve. Then, 15 sections (5 μm thick, every 500 μm) were performed and stained with safranin-hematoxylin-eosin at the level of the optic papilla. The sections were analyzed by light microscopy (DMR microscope fitted with 2.5×, 5×, 10×, 20×, 40×, or 63× objectives; Leica, Solms, Germany). Qualitative and semiquantitative histopathologic analyses of the sections were performed with special care taken to avoid damaging the ciliary process or inducing necrosis or degeneration and retinal changes. The following parameters were graded from 0 (absence) to 4 (severe): inflammatory reaction (macrophages, lymphocytes, plasma cells, polymorphonuclear cells, and giant cells), fibrocytes, fibrin, edema, hemorrhage, cellular and tissue degeneration, and necrosis.