Purchase this article with an account.
Christopher G. Owen, Iain M. Carey, Sunil Shah, Stephen de Wilde, Richard Wormald, Peter H. Whincup, Derek G. Cook; Hypotensive Medication, Statins, and the Risk of Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(7):3524-3530. doi: 10.1167/iovs.09-4821.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To examine whether treatment with oral blood-pressure–lowering medication or statins influences the risk of glaucoma.
This study was a case–control investigation, nested within a computerized primary care database of 177 general practices across the United Kingdom; 8778 cases diagnosed and/or treated for glaucoma between 2000 and 2007, and 8778 glaucoma-free controls matched for age, sex, and practice. Odds ratios for treatment with oral antihypertensives (including selective β1 and nonselective β-blockers) and statins in the 5 years before diagnosis were calculated by logistic regression, adjusted for a marker of socioeconomic position and number of drug types prescribed (as a measure of health service usage).
Prevalence of oral β-blocker use in the 5 years before diagnosis was lower in the cases (22.5%) than in the controls (23.6%), adjusted odds ratio (OR) 0.87 (95% confidence interval [CI], 0.80–0.94). This effect was presence with treatment with β1-selective medications (OR, 0.81; 95% CI, 0.74–0.88) but not with nonselective medications (OR, 1.08; 95% CI, 0.94–1.24). The prevalence of thiazide use was higher among the glaucoma cases than among the controls (OR, 1.13; 95% CI, 1.04–1.23). Neither statins nor other antihypertensive treatments were associated with the risk of glaucoma.
Oral β1 β-blockers may protect against development of glaucoma. The current consensus on the relative importance of β2 receptor blockade in treating glaucoma may have to be reviewed. Changes in prescribing oral β-blockers for cardiovascular disorders may affect the number of those who eventually have glaucoma. There is no evidence to suggest that statins have a preventive role in glaucoma.
This PDF is available to Subscribers Only