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Jaeryung Oh, Seong-Woo Kim, Soon-Sun Kwon, In Kyung Oh, Kuhl Huh; Correlation of Fundus Autofluorescence Gray Values with Vision and Microperimetry in Resolved Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2012;53(1):179-184. doi: https://doi.org/10.1167/iovs.11-8704.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the prognostic value of grayscale parameters in fundus autofluorescence (FAF) for visual function in resolved central serous chorioretinopathy (CSC).
Seventy-six eyes of 67 patients with CSC that had been resolved for more than 4 months were analyzed retrospectively. Both the short-wavelength (SW)-FAF and near infrared (NIR)-FAF gray value parameters, including the mean, standard deviation, and coefficient of variation (CV), were calculated at 350-μm- and 1200-μm-diameter circles centered on the fovea. The FAF gray value parameters correlated with −logMAR best corrected visual acuity (BCVA) and mean microperimetry (MP) at the 2° and 4° diameters from the foveal center.
The mean −logMAR BCVA was 0.15 ± 0.23. The mean MP was 12.87 ± 3.79 dB at 2° and 13.54 ± 3.37 dB at 4°. The −logMAR BCVA correlated most strongly with the mean SW-FAF gray value at the 350-μm circle centered around the fovea (SW-M350; ρ = 0.353; P = 0.002), and the SD of the SW-FAF gray value at the 350-μm circle centered around the fovea (SW-SD350) correlated most strongly with the MP at 2° (ρ = −0.416, P < 0.0001) and 4° (ρ = −0.435, P < 0.0001). The NIR-FAF gray value parameters did not correlate with the macular function tests.
In subjects with resolved CSC, FAF gray values correlated with visual function. BCVA correlated most strongly with SW-M350. MP at 2° and at 4° correlated most strongly with SW-SD350.
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